Volume 6 Supplement 1

15th Paediatric Rheumatology European Society (PreS) Congress

Meeting abstracts

Edited by Wietse Kuis, Patricia Woo, Angelo Ravelli, Hermann Girschick, Michaël Hofer, Johannes Roth, Rotraud K Saurenmann, Alberto Martini, Pavla Dolezova, Janjaap van der Net, Pierre Quartier, Lucy Wedderburn and Jan Scott

15th Paediatric Rheumatology European Society (PreS) Congress. Go to conference site.

London, UK14-17 September 2008

Concatenated PDF 6S1

Page 1 of 7

2.1 Long-term safety and efficacy of tocilizumab in children with systemic juvenile idiopathic arthritis (JIA)

Authors: S Yokota, T Imagawa, T Miyamae, K Kasai, M Mori, N Nishimoto and T Kishimoto

Citation: Pediatric Rheumatology 2008 6(Suppl 1):S1

Content type: Oral presentation Published on: 15 September 2008
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Analysis of the classical, alternative, and MBL pathways of the complement system in juvenile idiopathic arthritis

Authors: J Brunner, J Scheiring, B Petzelsberger, M Prelog and L-B Zimmerhackl

Citation: Pediatric Rheumatology 2008 6(Suppl 1):P1

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2.2 A phase II trial with canakinumab, a new IL-1beta blocking monoclonal antibody (ACZ885), to evaluate preliminary dosing, safety and efficacy profile in children with systemic Juvenile Idiopathic arthritis (sJIA)

Authors: N Ruperto, P Quartier, N Wulffraat, P Woo, A Loy, R Mouy, B Bader-Meunier, B Prakken, E Noseda and C Rordorf

Citation: Pediatric Rheumatology 2008 6(Suppl 1):S2

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The Damage Associated Molecular Pattern (DAMP) molecule S100A12 induces pro-inflammatory responses in monocytes via innate immunity signalling pathways

Authors: H Wittkowski, D Viemann, A Lueken, K Barczyk, T Vogl, J Roth and D Foell

Citation: Pediatric Rheumatology 2008 6(Suppl 1):P2

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2.3 Long-term efficacy and safety of infliximab plus methotrexate for the treatment of polyarticular course juvenile rheumatoid arthritis (JRA): Findings from an open-label treatment extension

Authors: N Ruperto, DJ Lovell, R Cuttica, P Woo, G Espada, C Wouters, ED Silverman, Z Balogh, M Henrickson, J Davidson, I Foeldvari, L Imundo, G Simonini, J Oppermann, YK Shen, S Visvanathan…

Citation: Pediatric Rheumatology 2008 6(Suppl 1):S3

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The influencing of environmental and genetics factors on bone metabolism in juvenile idiopathic arthritis children

Authors: MM Kostik, PB Glazkov, MV Moskalenko, DN Baranov, MA Pachomova, AA Kozyreva, LA Scheplyagina and VI Larionova

Citation: Pediatric Rheumatology 2008 6(Suppl 1):P3

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2.4 Magnetic resonance imaging, ultrasonography and conventional radiography in the assessment of bone erosions in juvenile idiopathic arthritis

Authors: C Malattia, MB Damasio, F Magnaguagno, A Pistorio, M Valle, C Martinoli, S Viola, A Buoncompagni, A Loy, A Ravelli, P Tomà and A Martini

Citation: Pediatric Rheumatology 2008 6(Suppl 1):S4

Content type: Oral presentation Published on: 15 September 2008
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May antihistone antibodies replace antinuclear antibodies (ANA) as a predictor of uveitis in Juvenile idiopathic arthritis?

Authors: EB Nordal, NT Songstad, B Straume, L Berntson and M Rygg

Citation: Pediatric Rheumatology 2008 6(Suppl 1):P4

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2.5 Mesenchymal Stem Cell Therapy has significant clinical effect in proteoglycan induced arthritis

Authors: JF Swart, MJG Backer, F Hofhuis, W de Jager, BJ Prakken, W Kuis, ACM Martens and NM Wulffraat

Citation: Pediatric Rheumatology 2008 6(Suppl 1):S5

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A juvenile idiopathic arthritis biobank at the Royal Children's Hospital, Melbourne, Australia

Authors: J Ellis, S Macnee, A-L Ponsonby, J Akikusa, R Allen and J Munro

Citation: Pediatric Rheumatology 2008 6(Suppl 1):P5

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3.4 Physical activity in adolescents with juvenile idiopathic arthritis

Authors: OTHM Lelieveld, W Armbrust, MA van Leeuwen, N Duppen, JHB Geertzen, PJJ Sauer and E van Weert

Citation: Pediatric Rheumatology 2008 6(Suppl 1):S6

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Tumor necrosis factor-alpha polymorphism and susceptibility to juvenile idiopathic arthritis

Authors: S Bayraktar, O Kasapcopur, N Arisoy, B Batar and M Guven

Citation: Pediatric Rheumatology 2008 6(Suppl 1):P6

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3.5 Comparison of functional ability in juvenile idiopathic arthritis, juvenile dermatomyositis, juvenile systemic lupus erythematosus and healthy controls. An analysis of the PRINTO database

Authors: G Filocamo, S Meiorin, C Saad-Magalhães, A Pistorio, A Ravelli, E Cortis, D Mihaylova, M Alessio, O Arguedas, S Garay, A Martini and N Ruperto

Citation: Pediatric Rheumatology 2008 6(Suppl 1):S7

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Are genetic variants of Caspase-1 and Cryopyrin associated with systemic JIA?

Authors: CJ Stock, EM Ogilvie, JM Samuel, M Fife and P Woo

Citation: Pediatric Rheumatology 2008 6(Suppl 1):P7

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4.4 Different phenotype of anaemia in systemic juvenile idiopathic arthritis (s-JIA) compared to anaemia in other subtypes of JIA

Authors: CH Hinze, N Fall, MG Barnes, S Croswell, K Jennings, S Thornton, RA Colbert, DN Glass and AA Grom

Citation: Pediatric Rheumatology 2008 6(Suppl 1):S8

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Role of Vγ9Vδ2+ γδ T cells in juvenile idiopathic arthritis

Authors: M Gerstein, A Bendersky, S Padeh, I Bank and Y Berkun

Citation: Pediatric Rheumatology 2008 6(Suppl 1):P8

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4.5 Defective phosphorylation of the interleukin 18 receptor beta-chain causes impaired NK cell function in systemic onset Juvenile Idiopathic Arthritis

Authors: W de Jager, SJ Vastert, JM Beekman, NM Wulffraat, W Kuis, PJ Coffer and BJ Prakken

Citation: Pediatric Rheumatology 2008 6(Suppl 1):S9

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Diagnostic value and clinical significance of antibodies against a modified citrullinated vimentin (anti-MCV) in patients with early juvenile arthritis

Authors: SO Salugina, ES Fedorov, EN Alexandrova, AA Novikov, MV Cherkasova, AA Baranov, YA Valogina, TN Nikolaeva and NA Zubova

Citation: Pediatric Rheumatology 2008 6(Suppl 1):P9

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6.4 Spondylo-epiphyseal dysplasia – a physiotherapy approach

Authors: H Mato, N Hasson, C Pilkington and S Maillard

Citation: Pediatric Rheumatology 2008 6(Suppl 1):S10

Content type: Oral presentation Published on: 15 September 2008
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CD39: a regulatory role in childhood arthritis

Authors: H Moncrieffe, K Nistala, P Hunter, Y Kamhieh and L Wedderburn

Citation: Pediatric Rheumatology 2008 6(Suppl 1):P10

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7.1 Transgenic overexpression of CREM alpha in murine T cells results in an anergic phenotype with enhanced IL17 production

Authors: RL Lippe, KS Sturm, JR Roth and KT Tenbrock

Citation: Pediatric Rheumatology 2008 6(Suppl 1):S11

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The TRAF1/C5 region is a risk factor for polyarthritis in juvenile idiopathic arthritis

Authors: HM Albers, FAS Kurreeman, JJ Houwing-Duistermaat, DMC Brinkman, SSM Kamphuis, HJ Girschick, C Wouters, MAJ van Rossum, W Verduyn, REM Toes, TWJ Huizinga, MW Schilham and R ten Cate

Citation: Pediatric Rheumatology 2008 6(Suppl 1):P11

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7.2 Interleukin-17 (IL-17) secreting cells in synovial fluid express the "Th17" master transcription factor RORC and their numbers correlate with CCL20 levels within the joint

Authors: K Nistala, P Hunter, E Sala-Soriano, J Diss and LR Wedderburn

Citation: Pediatric Rheumatology 2008 6(Suppl 1):S12

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The role of synovial fluid cytokines IL-6, IL-23 and IL-17 in the pathogenesis and persistence of synovial inflammation in JIA patients

Authors: V Tzimouli, M Trachana, A Taparkou, P Pratsidou-Gertsi, S Metsovitis, G Pardalos and F Kanakoudi-Tsakalidou

Citation: Pediatric Rheumatology 2008 6(Suppl 1):P12

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7.3 Successful use of anakinra, a soluble IL-1 receptor antagonist, in pediatric rheumatic diseases associated macrophage activation syndrome/reactive hemophagocytic lymphohistiocytosis

Authors: PM Miettunen, A Jayanthan and A Narendran

Citation: Pediatric Rheumatology 2008 6(Suppl 1):S13

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FOXP3 expression in peripheral blood and synovial cells of patients with juvenile idiopathic arthritis: relationship with IL-17 at cytokine and molecular level

Authors: B Olivito, S Ciullini, M Moriondo, L Betti, E Gambineri, G Simonini, C Azzari, M De Martino and R Cimaz

Citation: Pediatric Rheumatology 2008 6(Suppl 1):P13

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7.4 Improvements in individual disease components are sustained with long-term adalimumab therapy for polyarticular Juvenile Idiopathic Arthritis

Authors: N Ruperto, D Lovell, S Goodman, A Reiff, D Nemcová, P Quartier, R Joos, V Gerloni, J Bohnsack, L Wagner-Weiner, HI Huppertz, N Olson, J Medich, M McIlraith, A Martini and E Giannini

Citation: Pediatric Rheumatology 2008 6(Suppl 1):S14

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Association between IL2RA and juvenile idiopathic arthritis (JIA) disease severity at first presentation to paediatric rheumatology: results from the Childhood Arthritis Prospective Study (CAPS)

Authors: KL Hyrich, SD Lal, A Hinks, LR Wedderburn, J Gardner-Medwin, H Foster, A Chieng, J Davidson, E Baildam and W Thomson

Citation: Pediatric Rheumatology 2008 6(Suppl 1):P14

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7.5 Safety data from over 1,200 patients-years of methotrexate and/or etanercept treatment in children with polyarticular or systemic juvenile rheumatoid arthritis

Authors: EH Giannini, NT Ilowite, DJ Lovell, CA Wallace, CE Rabinovich, A Reiff, G Higgins, B Gottlieb, Y Chon, SW Baumgartner and S-L Lin

Citation: Pediatric Rheumatology 2008 6(Suppl 1):S15

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Single-nucleotide polymorphisms in the folate pathway are associated with response to methotrexate treatment in juvenile idiopathic arthritis

Authors: MW Heijstek, NM Wulffraat, Y Eken, SMF Pluijm, CMA Rademaker and R de Jonge

Citation: Pediatric Rheumatology 2008 6(Suppl 1):P15

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7.6 Long-term treatment with glucocorticoids and low bone mass: a longitudinal study in 266 children and adolescents

Authors: M Biggioggero, ML Bianchi, C Limonta, S Vai, L Ghio, C Colombo, A Edefonti, F Corona, G Nebbia, L Morandi and A Colombini

Citation: Pediatric Rheumatology 2008 6(Suppl 1):S16

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MTHFR polymorphism and red cell folate levels are not useful as biomarkers of methotrexate efficacy and toxicity in children with juvenile idiopathic arthritis

Authors: J Tuková, M Hroch and P Doležalová

Citation: Pediatric Rheumatology 2008 6(Suppl 1):P16

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8.3 Disease patterns in Danish Juvenile Dermatomyositis patients

Authors: PR Mathiesen, M Zak, T Herlin and SM Nielsen

Citation: Pediatric Rheumatology 2008 6(Suppl 1):S17

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High membrane expression of CD163 by bone marrow cells is not a specific marker of macrophage activation syndrome (MAS)

Authors: C Bracaglia, R Devito, A Insalaco, PS Buonuomo, A Campana, E Cortis and AG Ugazio

Citation: Pediatric Rheumatology 2008 6(Suppl 1):P17

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8.4 Novel autoantibodies targeting a p140 protein are a major autoantigen system in juvenile dermatomyositis and a marker of calcinosis

Authors: H Gunawardena, LR Wedderburn, ZE Betteridge, H Chinoy, J North, RG Cooper, AV Ramanan, JE Davidson and NJ McHugh

Citation: Pediatric Rheumatology 2008 6(Suppl 1):S18

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Lymph act, TCR αβ, TCR γδ cells in peripheral blood in children with juvenile idiopathic arthritis

Authors: H Mazur-Zielinska

Citation: Pediatric Rheumatology 2008 6(Suppl 1):P18

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8.5 Predictors of long-term outcome of Juvenile Dermatomyositis (JDM): a Multicenter, Multinational Study of 490 patients

Authors: C Ferrari, L Trail, C Pilkington, S Maillard, R Cuttica, MM Katsicas, R Russo, M Bandeira, V Ferriani, S Oliveira, C Saad-Magalhaes, CA Silva, V Baca, R Burgos-Vargas, E Solis-Vallejo, M Alessio…

Citation: Pediatric Rheumatology 2008 6(Suppl 1):S19

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Activated CD27+ and CD27- memory B cells accumulate in the joints of patients with juvenile idiopathic arthritis

Authors: H Morbach, N Suffa, P Richl and HJ Girschick

Citation: Pediatric Rheumatology 2008 6(Suppl 1):P19

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Abstract withdrawn

Authors:

Citation: Pediatric Rheumatology 2008 6(Suppl 1):P20

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9.1 Innate resistance of endothelial cells to the effects of glucocorticoids

Authors: P Koenen, K Barczyk, M Wolf, J Roth and D Viemann

Citation: Pediatric Rheumatology 2008 6(Suppl 1):S20

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9.2 QT interval dispersion in North Indian children with Kawasaki disease

Authors: S Ghelani, S Singh and R Manoj Kumar

Citation: Pediatric Rheumatology 2008 6(Suppl 1):S21

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Characterization of B cells in synovial fluid and tissue from patients with JIA

Authors: F Ferlito, A Corcione, E Traggiai, A Gregorio, A Martini, V Pistoia and M Gattorno

Citation: Pediatric Rheumatology 2008 6(Suppl 1):P21

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9.3 Endothelial progenitor cells and vasculogenic responses to therapy in children with primary systemic vasculitis

Authors: LA Clarke, Y Hong, D Eleftheriou, N Klein and PA Brogan

Citation: Pediatric Rheumatology 2008 6(Suppl 1):S22

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Methotrexate in childhood arthritis: effects on gene expression

Authors: H Moncrieffe, S Ursu, A Etheridge, L Kassoumeri, A Stansfield, N Jina and L Wedderburn

Citation: Pediatric Rheumatology 2008 6(Suppl 1):P22

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Methotrexate does not primarily affect Foxp3+ regulatory T cells in poly-articular juvenile idiopathic arthritis

Authors: SJ Vastert, FJ Verweij, W de Jager, NM Wulffraat, F van Wijk and BJ Prakken

Citation: Pediatric Rheumatology 2008 6(Suppl 1):P23

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9.4 Autoantibodies in pediatric systemic lupus erythematosus: ethnic grouping, autoantibody clustering and clinical correlations

Authors: R Jurencak, MJ Fritzler, PN Tyrrell, LT Hiraki, SM Benseler and ED Silverman

Citation: Pediatric Rheumatology 2008 6(Suppl 1):S23

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12.2 Mevalonate kinase deficiency: Impaired isoprenoid synthesis induces IL-1beta production via activation of Rac1

Authors: LM Kuijk, J Frenkel, HR Waterham, J Koster and PJ Coffer

Citation: Pediatric Rheumatology 2008 6(Suppl 1):S24

Content type: Oral presentation Published on: 15 September 2008
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Outcome of repeat dosing of sJIA patients with tocilizumab in one UK centre

Authors: P Livermore, T Woodworth and P Woo

Citation: Pediatric Rheumatology 2008 6(Suppl 1):P24

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12.3 Long-term follow up of patients with CINCA syndrome: efficacy and tolerability of Anakinra treatment

Authors: G Paloni, M Gattorno, M Alessio, D Rigante, M Cattalini, F Zulian and L Lepore

Citation: Pediatric Rheumatology 2008 6(Suppl 1):S25

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Systemic-onset juvenile rheumatoid arthritis and ANCA-associated glomerulonephritis

Authors: A Belot, B Bader-Meunier, LH Noel, AM Prieur, P Niaudet, R Salomon and P Quartier

Citation: Pediatric Rheumatology 2008 6(Suppl 1):P25

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15th Paediatric Rheumatology European Society (PreS) Congress

Meeting abstracts

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Pediatric Rheumatology

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