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Association between IL2RA and juvenile idiopathic arthritis (JIA) disease severity at first presentation to paediatric rheumatology: results from the Childhood Arthritis Prospective Study (CAPS)
Pediatric Rheumatology volume 6, Article number: P14 (2008)
CAPS was designed to study clinical and genetic predictors of JIA outcome. The gene IL2RA has recently emerged as a JIA susceptibility locus. This study investigates the association between SNPs located within the IL2RA region and disease severity at first presentation to rheumatology.
Demographic and disease features were collected at first presentation to rheumatology. SNPs(rs2104286, rs41295061, rs11594656) were genotyped on a Sequenom MassARRAY® platform. Logistic regression, adjusted for ILAR subtype, was used to determine the association between genotype and moderate to severe disability(defined as CHAQ score ≥ 0.75).
185 children with JIA (median age 7.2 years(IQR 3.6, 11.7), 65% female) were included. Median CHAQ score at presentation was 0.75(IQR 0.13, 1.38). There was a trend towards higher disability with increased number of copies of the rare allele of rs2104286 (Table 1) (OR 8.00 (0.93, 68.79), p = 0.06). An association was also seen between increased disability and homozygosity for the rare allele of rs11594656 (OR 3.37 (0.89–12.75), p = 0.07). There was no association with rs41295061.
Children homozygous for the rare allele (rs2104286) a SNP associated with JIA susceptibility, showed a trend towards increased disability. Interestingly, a second SNP in the IL2RA region not previously associated with JIA susceptibility also showed a similar trend. Validation of these results in larger cohorts is required.
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Hyrich, K., Lal, S., Hinks, A. et al. Association between IL2RA and juvenile idiopathic arthritis (JIA) disease severity at first presentation to paediatric rheumatology: results from the Childhood Arthritis Prospective Study (CAPS). Pediatr Rheumatol 6, P14 (2008) doi:10.1186/1546-0096-6-S1-P14
- Public Health
- Logistic Regression
- Disease Severity
- Large Cohort