Volume 6 Supplement 1

15thPaediatric Rheumatology European Society (PreS) Congress

Open Access

Association between IL2RA and juvenile idiopathic arthritis (JIA) disease severity at first presentation to paediatric rheumatology: results from the Childhood Arthritis Prospective Study (CAPS)

  • KL Hyrich1,
  • SD Lal1,
  • A Hinks1,
  • LR Wedderburn2,
  • J Gardner-Medwin3,
  • H Foster5,
  • A Chieng6,
  • J Davidson3,
  • E Baildam4 and
  • W Thomson1
Pediatric Rheumatology20086(Suppl 1):P14

https://doi.org/10.1186/1546-0096-6-S1-P14

Published: 15 September 2008

Background

CAPS was designed to study clinical and genetic predictors of JIA outcome. The gene IL2RA has recently emerged as a JIA susceptibility locus. This study investigates the association between SNPs located within the IL2RA region and disease severity at first presentation to rheumatology.

Methods

Demographic and disease features were collected at first presentation to rheumatology. SNPs(rs2104286, rs41295061, rs11594656) were genotyped on a Sequenom MassARRAY® platform. Logistic regression, adjusted for ILAR subtype, was used to determine the association between genotype and moderate to severe disability(defined as CHAQ score ≥ 0.75).

Results

185 children with JIA (median age 7.2 years(IQR 3.6, 11.7), 65% female) were included. Median CHAQ score at presentation was 0.75(IQR 0.13, 1.38). There was a trend towards higher disability with increased number of copies of the rare allele of rs2104286 (Table 1) (OR 8.00 (0.93, 68.79), p = 0.06). An association was also seen between increased disability and homozygosity for the rare allele of rs11594656 (OR 3.37 (0.89–12.75), p = 0.07). There was no association with rs41295061.

Table 1

Gene IL2RA

N(%)

Median CHAQ score(IQR)*

OR CHAQ ≥ 0.75(95% CI), p-value

   

Unadjusted

Adjusted

rs2104286

185

   

11

119(64)

0.75(0.13, 1.38)

Ref

Ref

12

58(31)

0.81(0.25, 1.38)

1.06(0.56, 1.99), p = 0.86

1.05(0.54, 2.03), p = 0.88

22

8(4)

0.94(0.81, 1.38)

6.02(0.72, 50.42), p = 0.09

8.00(0.93, 68.79), p = 0.06

rs11594656

185

   

11

100(54)

0.88(0.13, 1.44)

Ref

Ref

12

68(37)

0.63(0.13, 1.07)

0.63(0.34, 1.18), p = 0.15

0.64(0.33, 1.21), p = 0.17

22

17(9)

1.38(0.88, 1.88)

3.52(0.95, 13.02), p = 0.06

3.37(0.89, 12.75), p = 0.07

Conclusion

Children homozygous for the rare allele (rs2104286) a SNP associated with JIA susceptibility, showed a trend towards increased disability. Interestingly, a second SNP in the IL2RA region not previously associated with JIA susceptibility also showed a similar trend. Validation of these results in larger cohorts is required.

Authors’ Affiliations

(1)
University of Manchester
(2)
Institute of Child Health
(3)
Royal Hospital for Sick Children
(4)
Royal Liverpool Children's Hospital
(5)
University of Newcastle
(6)
Royal Manchester Children's Hospital

Copyright

© Hyrich et al; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.

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