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Tumor necrosis factor-alpha polymorphism and susceptibility to juvenile idiopathic arthritis


Juvenile idiopathic arthritis (JIA) is a complex, multifactorial and chronic inflammatory disease of unknown etiology with considerable variability in which tumor necrosis factor-alpha (TNF-α) plays an important role. Both genetic and environmental factors can contribute to a susceptibility to disease initiation as well as a severity of disease course. TNF-α polymorphisms may be an independent marker of susceptibility and severity of JIA. The aim of this study was to elucidate putative association between the -863 C/A polymorphism in the promoter region of the TNF-a gene and susceptibility to onset and severity of JIA.


We used PCR-RFLP (polymerase chain reaction – restriction fragment length polymorphism) method to detect the -863 C/A polymorphism. We analyzed DNA samples from 76 patients with JIA and 80 healthy individuals.


The distribution of TNF-α genotypes in cases differed significantly from that in the controls, comparing TNF-α A carriers (CA or AA genotypes) with noncarriers (CC genotype) (OR = 2.49; 95% CI: 1.21–5.14; P = 0.01). However, TNF-α -863 C/A allele frequencies were not significantly different between cases and controls.


The TNF-α CC genotype was associated with increased risk factor for JIA in a sample of Turkish patients.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Bayraktar, S., Kasapcopur, O., Arisoy, N. et al. Tumor necrosis factor-alpha polymorphism and susceptibility to juvenile idiopathic arthritis. Pediatr Rheumatol 6 (Suppl 1), P6 (2008).

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