- Oral presentation
- Open Access
8.5 Predictors of long-term outcome of Juvenile Dermatomyositis (JDM): a Multicenter, Multinational Study of 490 patients
Pediatric Rheumatologyvolume 6, Article number: S19 (2008)
Background and objective
Little information exists on long-term outcome of JDM. Furthermore, most studies have been conducted in single centres or have involved a few patients. Objective of the study is to identify predictors of a poorer long-term outcome of JDM in a multicenter cohort of patients.
490 patients with JDM and disease duration > 2 years seen in 27 centers in 5 countries (Italy, UK, Argentina, Brazil, Mexico) after 1980 were identified. Outcomes included muscle weakness (MMT), continued activity (DAS), cumulative damage (MDI), calcinosis, lipodystrophy, functional impairment (CHAQ), and health-related quality of life (HRQL) impairment (CHQ). Predictors included: continent (Europe vs. Latin America), gender, year of onset, onset age, onset type (acute vs. insidious), onset manifestations, severity of muscle/skin manifestations at onset, and course type (monocyclic, polycyclic, chronic continuous).
Table 1 shows significant predictors for each outcome.
The chronic continuous course predicted all outcomes, which highlights the critical need for treatments and treatment strategies that have the ability to better control disease activity over time.