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  • Open Access

The TRAF1/C5 region is a risk factor for polyarthritis in juvenile idiopathic arthritis

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Pediatric Rheumatology20086 (Suppl 1) :P11

  • Published:


  • Public Health
  • Rheumatoid Arthritis
  • Arthritis
  • Environmental Factor
  • Allele Frequency


Juvenile idiopathic arthritis (JIA) is a chronic disorder in which both genetic and environmental factors are involved. Recently we identified the TRAF1/C5 region (located on chromosome 9q33-34) as a risk factor for rheumatoid arthritis (RA) (pcombined = 1.4 × 10-8) [1]. In the present study the association of the TRAF1/C5 region with the susceptibility to JIA was investigated.


A case-control association study was performed in 338 Caucasian JIA patients and 511 healthy individuals. We genotyped SNP rs10818488 as a marker for the TRAF1/C5 region.


The A-allele was associated with the susceptibility to Rheumatoid Factor (RF) negative polyarthritis with an 11% increase in allele frequency (OR 1.54, 95% CI 1.09–2.18; p = 0.012). This association was stronger when combining subtypes with a polyarticular phenotype (OR 1.46, 95% CI 1.12–1.90; p = 0.004). In addition, we observed a trend towards an increase in A-allele frequency in patients with extended oligoarthritis versus persistent oligoarthritis (49% and 38% respectively); p = 0.055.


Apart from being a well replicated risk factor for RA, TRAF1/C5 also appears to be a risk factor for the RF negative polyarthritis subtype of JIA and, more generally, seems to be associated with subtypes of JIA characterized by a polyarticular course.

Authors’ Affiliations

Leiden University Medical Center, Leiden, Netherlands
Erasmus Medical Center – Sophia Children's Hospital, Rotterdam, Netherlands
University of Wuerzburg, Wuerzburg, Germany
University Hospital Gasthuisberg, Leuven, Belgium
Emma Children's Hospital AMC, Amsterdam, Netherlands


  1. Kurreeman FA, Padyukov L, Marques RB, Schrodi SJ, Seddighzadeh M, Stoeken-Rijsbergen G, Helm-van Mil van der AH, Allaart CF, Verduyn W, Houwing-Duistermaat J: A candidate gene approach identifies the TRAF1/C5 region as a risk factor for rheumatoid arthritis. PLoS Med. 2007, 4: e278-10.1371/journal.pmed.0040278.PubMed CentralView ArticlePubMedGoogle Scholar


© Albers et al; licensee BioMed Central LtdAlbers et al; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.