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  1. Severe pain and impairments in functioning are commonly reported for youth with juvenile fibromyalgia. The prevalence and impact of pain in other diseases commonly managed in pediatric rheumatology comparative...

    Authors: Mark Connelly and Jenifer E. Weiss

    Citation: Pediatric Rheumatology 2019 17:72

    Content type: Research article

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  2. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with marked variation in its clinical presentation. Juvenile SLE (jSLE) accounts for 15–20% of all cases and is diagnosed when SLE manifests b...

    Authors: D. O’Leary, C. O’Connor, L. Nertney, E. J. MacDermott, D. Mullane, O. Franklin and O. G. Killeen

    Citation: Pediatric Rheumatology 2019 17:71

    Content type: Case Report

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  3. Despite recent advances in the diagnosis and understanding of many autoinflammatory diseases, there are still a great number of patients with phenotypes that do not fit any clinically- and/or genetically-defin...

    Authors: Lori B. Tucker, Lovro Lamot, Iwona Niemietz, Brian K. Chung, David A. Cabral, Kristin Houghton, Ross E. Petty, Kimberly A. Morishita, Gillian I. Rice, Stuart E. Turvey, William T. Gibson and Kelly L. Brown

    Citation: Pediatric Rheumatology 2019 17:70

    Content type: Case Report

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  4. Endothelium is a key element in the regulation of vascular homeostasis and its alteration can lead to the development of vascular diseases. Systemic lupus erythematosus (SLE) is a systemic autoimmune disease w...

    Authors: Wan-Fang Lee, Chao-Yi Wu, Huang-Yu Yang, Wen-I Lee, Li-Chen Chen, Liang-Shiou Ou and Jing-Long Huang

    Citation: Pediatric Rheumatology 2019 17:69

    Content type: Research article

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  5. Infrared Thermography (IRT) has been used for over 30 years in the assessment of Raynaud Phenomenon (RP) and other peripheral microvascular dysfunctions in adults but, to date, very little experience is availa...

    Authors: Giorgia Martini, Michela Cappella, Roberta Culpo, Fabio Vittadello, Monica Sprocati and Francesco Zulian

    Citation: Pediatric Rheumatology 2019 17:68

    Content type: Research article

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  6. Biologic medications have dramatically enhanced the treatment of many chronic paediatric inflammatory conditions. Their high cost is a factor that prohibits their broader use. Cheaper generic versions, or bios...

    Authors: William D. Renton, Helen Leveret, Catherine Guly, Heather Smee, Jamie Leveret and Athimalaipet V. Ramanan

    Citation: Pediatric Rheumatology 2019 17:67

    Content type: Research article

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  7. JIA-associated uveitis (JIAU) is a serious, sight-threatening disease with significant long-term complications and risk of blindness, even with improved contemporary treatments. The MIWGUC was set up in order ...

    Authors: Ivan Foeldvari, Jens Klotsche, Gabriele Simonini, Clive Edelsten, Sheila T. Angeles-Han, Regitze Bangsgaard, Joke de Boer, Gabriele Brumm, Rosa Bou Torrent, Tamas Constantin, Cinzia DeLibero, Jesus Diaz, Valeria Maria Gerloni, Margarida Guedes, Arnd Heiligenhaus, Kaisu Kotaniemi…

    Citation: Pediatric Rheumatology 2019 17:66

    Content type: Research article

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  8. The prediction of resistance to intravenous immunoglobulins (IVIG) is currently still one of the main research areas in Kawasaki disease (KD). Several studies have reported on the use of N-terminal pro-brain n...

    Authors: Shuran Shao, Chunyan Luo, Kaiyu Zhou, Yimin Hua, Mei Wu, Lei Liu, Xiaoliang Liu and Chuan Wang

    Citation: Pediatric Rheumatology 2019 17:65

    Content type: Research article

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  9. In adult patients with arthritis, use of the tumor necrosis factor (TNF) inhibitor etanercept (ETN) is often associated with a reduction in the utilization of co-medications, particularly steroids. Comparative...

    Authors: Majed Khraishi, Brad Millson, John Woolcott, Heather Jones, Lisa Marshall and Nicolino Ruperto

    Citation: Pediatric Rheumatology 2019 17:64

    Content type: Research article

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  10. To determine the serum levels of the lectin pathway proteins early in the disease course and 17 years after disease onset and to correlate the protein levels to markers of disease activity in participants from...

    Authors: Mia Glerup, Steffen Thiel, Veronika Rypdal, Ellen Dalen Arnstad, Maria Ekelund, Suvi Peltoniemi, Kristiina Aalto, Marite Rygg, Susan Nielsen, Anders Fasth, Lillemor Berntson, Ellen Nordal and Troels Herlin

    Citation: Pediatric Rheumatology 2019 17:63

    Content type: Research article

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  11. To evaluate radiographic progression of patients with new-onset juvenile idiopathic arthritis (JIA) in response to an early, tightly-controlled, treatment-to-target.

    Authors: P. C. E. Hissink Muller, W. G. van Braak, D. Schreurs, C. M. Nusman, S. A. Bergstra, R. Hemke, D. Schonenberg-Meinema, J. M. van den Berg, T. W. Kuijpers, Y. Koopman-Keemink, M. A. J. van Rossum, L. W. A. van Suijlekom-Smit, D. M. C. Brinkman, C. F. Allaart, R. ten Cate and M. Maas

    Citation: Pediatric Rheumatology 2019 17:62

    Content type: Research article

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  12. Despite the increased use of rituximab in treating pediatric patients with autoimmune diseases in the last decade, there are limited data on rituximab safety in those subjects who have a developing immune syst...

    Authors: Amer M. Khojah, Michael L. Miller, Marisa S. Klein-Gitelman, Megan L. Curran, Victoria Hans, Lauren M. Pachman and Ramsay L. Fuleihan

    Citation: Pediatric Rheumatology 2019 17:61

    Content type: Research article

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  13. While pain is a common symptom in JIA patients, it remains unclear why some JIA patients develop ongoing or persistent pain. Complex clinical and social settings confound analysis of individual factors that ma...

    Authors: Annastazia E. Learoyd, Debajit Sen and Maria Fitzgerald

    Citation: Pediatric Rheumatology 2019 17:60

    Content type: Research article

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  14. The COPA syndrome is a newly recognized monogenic, autosomal dominant autoimmune disease presenting mostly presenting in childhood. Clinical features include inflammation of the lungs, kidneys, and joints. App...

    Authors: Anjali Patwardhan and Charles H. Spencer

    Citation: Pediatric Rheumatology 2019 17:59

    Content type: Review

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  15. Juvenile idiopathic arthritis (JIA) has been categorized into seven different categories according to the International League of Associations for Rheumatology (ILAR) criteria. Enthesitis-related arthritis (ER...

    Authors: Yang-Jen Shih, Yao-Hsu Yang, Chun-Ying Lin, Chia-Ling Chang and Bor-Luen Chiang

    Citation: Pediatric Rheumatology 2019 17:58

    Content type: Research article

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  16. The anti–interleukin-6 receptor-alpha antibody tocilizumab was approved for intravenous (IV) injection in the treatment of patients with systemic juvenile idiopathic arthritis (sJIA) aged 2 to 17 years based o...

    Authors: Navita L. Mallalieu, Sunethra Wimalasundera, Joy C. Hsu, Wendy Douglass, Chris Wells, Inmaculada Calvo Penades, Ruben Cuttica, Hans-Iko Huppertz, Rik Joos, Yukiko Kimura, Diana Milojevic, Margalit Rosenkranz, Kenneth Schikler, Tamas Constantin and Carine Wouters

    Citation: Pediatric Rheumatology 2019 17:57

    Content type: Research article

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  17. The idiopathic inflammatory myopathies (IIM) until recently have been considered a heterogeneous broad group of six autoimmune muscle diseases. Initially, autoantibodies in IIM (including JDM) and CD8+ T cell-...

    Authors: Anjali Patwardhan and Charles H. Spencer

    Citation: Pediatric Rheumatology 2019 17:56

    Content type: Review

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  18. Primary immunodeficiency diseases (PIDs) patients may show systemic lupus erythematosus (SLE)-like autoimmunity disorders, such as cytopenias, as well as polyarthritis, which leads to concerns of misdiagnosis....

    Authors: Wei Wang, Yu Zhou, Linqing Zhong, Lin Wang, Xiaoyan Tang, Mingsheng Ma, Ji Li and Hongmei Song

    Citation: Pediatric Rheumatology 2019 17:55

    Content type: Research article

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  19. In the last decade, incomplete Kawasaki disease (KD), intravenous immunoglobulin (IVIG) non-response and coronary artery abnormalities (CAA) have experienced the increasing trends in China. In addition, the en...

    Authors: Sama Samadli, Fei Fei Liu, Goshgar Mammadov, Jing Jing Wang, Hui Hui Liu, Yang Fang Wu, Huang Huang Luo, Yue Wu, Wei Xia Chen, Dong Dong Zhang, Wei Wei and Peng Hu

    Citation: Pediatric Rheumatology 2019 17:53

    Content type: Research article

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  20. Systemic lupus erythematosus (SLE) comprise a diverse range of clinical manifestations. To date, more than 30 single gene causes of lupus/lupus like syndromes in humans have been identified. In the clinical se...

    Authors: Irit Tirosh, Shiri Spielman, Ortal Barel, Reut Ram, Tali Stauber, Gideon Paret, Marina Rubinsthein, Itai M. Pessach, Maya Gerstein, Yair Anikster, Rachel Shukrun, Adi Dagan, Katerina Adler, Ben Pode-Shakked, Alexander Volkov, Marina Perelman…

    Citation: Pediatric Rheumatology 2019 17:52

    Content type: Research article

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  21. To describe the demographic, clinical, and treatment characteristics of youth diagnosed with juvenile primary fibromyalgia syndrome (JPFS) who are seen in pediatric rheumatology clinics.

    Authors: Jenifer E. Weiss, Kenneth N. Schikler, Alexis D. Boneparth and Mark Connelly

    Citation: Pediatric Rheumatology 2019 17:51

    Content type: Research article

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  22. To investigate the frequency of achievement of inactive disease (ID) in children with juvenile idiopathic arthritis (JIA) treated with methotrexate (MTX) as the sole disease-modifyng antirheumatic (DMARD) ther...

    Authors: Cecilia Bava, Federica Mongelli, Angela Pistorio, Marta Bertamino, Giulia Bracciolini, Sara Dalprà, Sergio Davì, Stefano Lanni, Valentina Muratore, Silvia Pederzoli, Silvia Rosina, Benedetta Schiappapietra, Chiara Suffia, Giulia Varnier, Sara Verazza, Gabriella Giancane…

    Citation: Pediatric Rheumatology 2019 17:50

    Content type: Research article

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  23. We describe a Childhood Arthritis and Rheumatology Research Alliance (CARRA) survey of North American pediatric rheumatologists that assesses physician attitudes on withdrawal of medications in systemic juveni...

    Authors: Susan Shenoi, Kabita Nanda, Grant S. Schulert, John F. Bohnsack, Ashley M. Cooper, Bridget Edghill, Miriah C. Gillispie-Taylor, Baruch Goldberg, Olha Halyabar, Thomas G. Mason, Tova Ronis, Rayfel Schneider, Richard K. Vehe and Karen Onel

    Citation: Pediatric Rheumatology 2019 17:48

    Content type: Research article

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  24. Children with juvenile idiopathic arthritis (JIA) have impaired physical abilities. TNF-α plays a crucial role in this pathogenesis, but it is also involved in the use of lipids and muscle health. Objective of...

    Authors: Emmanuelle Rochette, Pierre Bourdier, Bruno Pereira, Eric Doré, Anthony Birat, Sébastien Ratel, Stéphane Echaubard, Pascale Duché and Etienne Merlin

    Citation: Pediatric Rheumatology 2019 17:47

    Content type: Research article

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  25. The etiology of Kawasaki disease (KD) is still unknown; perinatal factors may have role with few studies. This study was aim to survey the perinatal factors and clinical outcome of KD, including coronary arter...

    Authors: Wei-Dong Huang, Yu-Ting Lin, Zi-Yu Tsai, Ling-Sai Chang, Shih-Feng Liu, Yi-Ju Lin and Ho-Chang Kuo

    Citation: Pediatric Rheumatology 2019 17:46

    Content type: Research article

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  26. Chronic non-bacterial osteomyelitis (CNO) is an autoinflammatory disorder of the skeletal system of yet unknown etiology. Patients present with local bone pain and inflammation and - to our experience - often ...

    Authors: Nentwich Julia, Ruf Katharina, Girschick Hermann, Holl-Wieden Annette, Morbach Henner, Hebestreit Helge and Hofmann Christine

    Citation: Pediatric Rheumatology 2019 17:45

    Content type: Research article

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  27. The aim of the study was to describe school attendance and participation in physical education in school among children with juvenile idiopathic arthritis (JIA).

    Authors: Ellen Nordal, Veronika Rypdal, Ellen Dalen Arnstad, Kristiina Aalto, Lillemor Berntson, Maria Ekelund, Anders Fasth, Mia Glerup, Troels Herlin, Susan Nielsen, Suvi Peltoniemi, Marek Zak, Nils Thomas Songstad and Marite Rygg

    Citation: Pediatric Rheumatology 2019 17:44

    Content type: Research article

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  28. We designed and initiated a pilot comparative effectiveness study for juvenile localized scleroderma (jLS), for which there is limited evidence on best therapy. We evaluated the process we used, in relation to...

    Authors: Suzanne C. Li, Robert C. Fuhlbrigge, Ronald M. Laxer, Elena Pope, Maria F. Ibarra, Katie Stewart, Thomas Mason II, Mara L. Becker, Sandy Hong, Fatma Dedeoglu, Kathryn S. Torok, C. Egla Rabinovich, Polly J. Ferguson, Marilynn Punaro, Brian M. Feldman, Tracy Andrews…

    Citation: Pediatric Rheumatology 2019 17:43

    Content type: Research article

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  29. Intraarticular corticosteroid injection (IACI) is one of the most common treatments in oligoarticular Juvenile Idiopathic Arthritis (JIA). Activity recommendations following injection vary, as there are no pub...

    Authors: Elaine R. Flanagan, Heather Benham, Janet Figueroa, Janille Diaz, Jenna Tress and David D. Sherry

    Citation: Pediatric Rheumatology 2019 17:42

    Content type: Research article

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  30. The pathology of juvenile dermatomyositis (JDM) is characterized by prominent vessel wall and perivascular inflammation. This feature of the disease has remained unexplained and under-investigated. We have hyp...

    Authors: Kaiyu Jiang, Rie Karasawa, Zihua Hu, Yanmin Chen, Lucy Holmes, Kathleen M. O’Neil and James N. Jarvis

    Citation: Pediatric Rheumatology 2019 17:41

    Content type: Research article

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  31. Juvenile Idiopathic Arthritis associated Uveitis (JIA-U) represents its most frequent extra-articular manifestation and the main cause of childhood uveitis in in developed countries. The broad variety of outco...

    Authors: Greta Mastrangelo, Ivan Foeldvari, Jordi Anton and Gabriele Simonini

    Citation: Pediatric Rheumatology 2019 17:40

    Content type: Review

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  32. Deficiency of adenosine deaminase 2 (DADA2) is a rare autosomal recessive autoinflammatory condition. Recognised features include vasculitis predominantly affecting medium sized vessels, livedoid skin rash, ce...

    Authors: Katherine Clarke, Cathy Campbell, Ebun Omoyinmi, Ying Hong, Muthana Al Obaidi, Neil Sebire and Paul A. Brogan

    Citation: Pediatric Rheumatology 2019 17:39

    Content type: Case Report

    Published on:

  33. Autosomal dominant gain of function mutations in caspase recruitment domain family member 14 (CARD14) is a rare condition associated with plaque-type psoriasis, generalized pustular psoriasis, palmoplantar pus...

    Authors: S. Signa, E. Campione, M. Rusmini, S. Chiesa, A. Grossi, A. Omenetti, R. Caorsi, G. M. Viglizzo, M. Galluzzo, L. Bianchi, M. Talamonti, A. Orlandi, A. Martini, I. Ceccherini and M. Gattorno

    Citation: Pediatric Rheumatology 2019 17:38

    Content type: Case Report

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  34. Deficiency of interleukin-36 receptor antagonist (DITRA) is a life threatening monogenic autoinflammatory disease caused by loss of function mutations in the IL36RN gene. Affected patients develop recurrent episo...

    Authors: Toni Hospach, Fabian Glowatzki, Friederike Blankenburg, Dennis Conzelmann, Christian Stirnkorb, Chris Sandra Müllerschön, Peter von den Driesch, Lisa Maria Köhler, Meino Rohlfs, Christoph Klein and Fabian Hauck

    Citation: Pediatric Rheumatology 2019 17:37

    Content type: Review

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  35. Cryopyrin-associated periodic syndrome (CAPS) is a rare autoinflammatory disease, caused by gain of function mutation in NLRP3 resulting in excess production of interleukin-1 (IL-1). Canakinumab is a human monocl...

    Authors: Abdulkadir A. Elmi, Karen Wynne, Iek L. Cheng, Despina Eleftheriou, Helen J. Lachmann, Philip N. Hawkins and Paul Brogan

    Citation: Pediatric Rheumatology 2019 17:36

    Content type: Research article

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  36. Kawasaki disease (KD) is a systemic vasculitis which may be associated with coronary artery aneurysms. A notable risk factor for the development of coronary artery aneurysms is resistance to intravenous immuno...

    Authors: Yuji Amano, Yohei Akazawa, Jun Yasuda, Kazuhisa Yoshino, Katsuhiko Kojima, Norimoto Kobayashi, Satoshi Matsuzaki, Masao Nagasaki, Yosuke Kawai, Naoko Minegishi, Noriko Ishida, Noriko Motoki, Akira Hachiya, Yozo Nakazawa, Masayuki Yamamoto, Kenichi Koike…

    Citation: Pediatric Rheumatology 2019 17:34

    Content type: Research article

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  37. The etiology of Juvenile Idiopathic Arthritis (JIA) is poorly understood. The purpose of this study was to examine the possible influence of early nutrition on later development of JIA.

    Authors: Erik Kindgren, Carlos Guerrero-Bosagna and Johnny Ludvigsson

    Citation: Pediatric Rheumatology 2019 17:33

    Content type: Research article

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  38. Childhood-onset systemic erythematosus lupus (cSLE) is characterized by more severe disease, widespread organ involvement and higher mortality compared to adult-onset SLE. However, cSLE is largely underfunded ...

    Authors: Stacy P. Ardoin, R Paola Daly, Lyna Merzoug, Karin Tse, Kaveh Ardalan, Lisa Arkin, Andrea Knight, Tamar Rubinstein, Natasha Ruth, Scott E. Wenderfer and Aimee O. Hersh

    Citation: Pediatric Rheumatology 2019 17:32

    Content type: Research article

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  39. Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) refers to a complex group of systemic vasculitides that are characterized by primary small-to-medium sized blood vessel inflammation with...

    Authors: Jennifer J. Y. Lee, Alhanouf Alsaleem, Grace P. K. Chiang, Elizaveta Limenis, Watchareewan Sontichai, Rae S. M. Yeung, Jonathan Akikusa and Ronald M. Laxer

    Citation: Pediatric Rheumatology 2019 17:31

    Content type: Review

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  40. Juvenile Dermatomyositis is a rare, potentially life-threatening condition with no known cure. There is no published literature capturing how children and young people feel about their condition, from their pe...

    Authors: Polly Livermore, Suzanne Gray, Kathleen Mulligan, Jennifer N. Stinson, Lucy R. Wedderburn and Faith Gibson

    Citation: Pediatric Rheumatology 2019 17:30

    Content type: Research article

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  41. Relapsing periodic arthritis is a general term used for a group of diseases with recurring and periodic nature, in which the joints are intermittently involved. The aim of this study is to evaluation of the po...

    Authors: Farhad Salehzadeh, Manuchehr Barak and Roghayeh Nematdoust Haghi

    Citation: Pediatric Rheumatology 2019 17:28

    Content type: Research article

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  42. Currently, there are no medications approved for the treatment of juvenile fibromyalgia (JFM). We evaluated the safety and efficacy of duloxetine 30/60 mg once daily (QD) versus placebo in adolescents with JFM.

    Authors: Himanshu P. Upadhyaya, Lesley M. Arnold, Karla Alaka, Meihua Qiao, David Williams and Renata Mehta

    Citation: Pediatric Rheumatology 2019 17:27

    Content type: Research article

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  43. Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare systemic vasculitis in children. A delayed or missed diagnosis of pediatric EGPA is common, owing to the atypical clinical manifestation and limit...

    Authors: Xiaoliang Liu, Lin Wang, Kaiyu Zhou, Yimin Hua, Xiaoqing Shi and Chuan Wang

    Citation: Pediatric Rheumatology 2019 17:26

    Content type: Case Report

    Published on:

  44. Systemic juvenile idiopathic arthritis (sJIA) is an inflammatory condition that presents with fever, rash and arthritis. At onset systemic features are predominant and the diagnosis may be a challenge. Seconda...

    Authors: Alessia Arduini, Emiliano Marasco, Giulia Marucci, Manuela Pardeo, Antonella Insalaco, Ivan Caiello, Gian Marco Moneta, Giusi Prencipe, Fabrizio De Benedetti and Claudia Bracaglia

    Citation: Pediatric Rheumatology 2019 17:25

    Content type: Short Report

    Published on:

  45. Prednisone (PDN) in juvenile dermatomyositis (JDM), alone or in association with other immunosuppressive drugs, namely methotrexate (MTX) and cyclosporine (CSA), represents the first-line treatment option for ...

    Authors: Gabriella Giancane, Claudio Lavarello, Angela Pistorio, Sheila K. Oliveira, Francesco Zulian, Ruben Cuttica, Michel Fischbach, Bo Magnusson, Serena Pastore, Roberto Marini, Silvana Martino, Anne Pagnier, Christine Soler, Valda Staņēvicha, Rebecca Ten Cate, Yosef Uziel…

    Citation: Pediatric Rheumatology 2019 17:24

    Content type: Research article

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  46. Young people (YP; 12–24 years old) with rheumatic diseases face many challenges associated with chronic illness in addition to the physiological and psychosocial changes of adolescence. Timely access to develo...

    Authors: Ran A. Cai, Hema Chaplin, Polly Livermore, Martin Lee, Debajit Sen, Lucy R. Wedderburn, Nick Wilkinson, Rachel Jeffery, Andrea Kempa, Imogen Norton, Rachel Tattersall, Yiannis Ioannou and Despina Eleftheriou

    Citation: Pediatric Rheumatology 2019 17:23

    Content type: Research article

    Published on:

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