Articles

Infections and antibiotics during fetal life and childhood and their relationship to juvenile idiopathic arthritis: a prospective cohort study

The aetiology of juvenile idiopathic arthritis (JIA) is poorly understood. It has been shown that use of antibiotics is associated with JIA. However, whether the association is due to increased occurrence of i...

Authors: Erik Kindgren and Johnny Ludvigsson

Tocilizumab for massive refractory pleural effusion in an adolescent with systemic lupus erythematosus

Pleural effusion in systemic lupus erythematous (SLE) is a common symptom, and recent studies demonstrated that IL-6 has a pivotal role in its pathogenesis.

Authors: Arianna De Matteis, Emanuela Sacco, Camilla Celani, Andrea Uva, Virginia Messia, Rebecca Nicolai, Manuela Pardeo, Fabrizio De Benedetti and Claudia Bracaglia

Reasons for canakinumab initiation among patients with periodic fever syndromes: a retrospective medical chart review from the United States

Although canakinumab has demonstrated efficacy in multiple trials in patients with periodic fever syndromes (PFS), the evidence on initiation of canakinumab among PFS patients in real world setting is not well...

Authors: Peter Hur, Kathleen G. Lomax, Raluca Ionescu-Ittu, Ameur M. Manceur, Jipan Xie, Jordan Cammarota, Raju Gautam, Navneet Sanghera, Nina Kim and Alexei A. Grom

Colchicine – an effective treatment for children with a clinical diagnosis of autoinflammatory diseases without pathogenic gene variants

Autoinflammatory diseases (AID) are rare chronic conditions with high disease burden, affecting children and adults. Clinically and genetically confirmed, AID can be effectively treated with targeted cytokine ...

Authors: Tatjana Welzel, Anna L. Wildermuth, Norbert Deschner, Susanne M. Benseler and Jasmin B. Kuemmerle-Deschner

Evaluating the performance of ACR, SLICC and EULAR/ACR classification criteria in childhood onset systemic lupus erythematosus

The ACR 1997, SLICC 2012 and EULAR/ACR 2019 classification criteria were validated based on adult patients. To date, there are no classification criteria specific for children with SLE. The aim of the study is...

Authors: Reem Abdwani, Eiman Masroori, Eiman Abdullah, Safiya Al Abrawi and Ibrahim Al-Zakwani

Biologic medicine inclusion in 138 national essential medicines lists

Essential medicines lists (EMLs) are intended to reflect the priority health care needs of populations. We hypothesized that biologic disease-modifying antirheumatic drugs (DMARDs) are underrepresented relativ...

Authors: Raphaël Kraus, Rae S. M. Yeung and Nav Persaud

Immunomodulatory treatment and surgical management of idiopathic uveitis and juvenile idiopathic arthritis-associated uveitis in children: a French survey practice

Surgeries for idiopathic uveitis and juvenile idiopathic arthritis-associated uveitis in children are complex because of the high risk of inflammatory postoperative complications. There is no consensus about t...

Authors: Julie Molimard, Christine Pajot, Priscille Olle, Alexandre Belot, Pierre Quartier, Florence Uettwiller, Chloé Couret, Valentine Coste, Camille Costet, Bahram Bodaghi, Pascal Dureau, Marion Bailhache and Pascal Pillet

Blau syndrome: a case report from Palestine

This case study documents the first familial case of Blau syndrome (BS) in Palestine characterized with mutation in CARD15/NOD2.

Authors: Salam Iriqat, Mohammed Abu Safieh, Manuel Fatouleh and Abdulsalam Alkaiyat

Differences in rituximab use between pediatric rheumatologists and nephrologists for the treatment of refractory lupus nephritis and renal flare in childhood-onset SLE

Consensus treatment plans have been developed for induction therapy of newly diagnosed proliferative lupus nephritis (LN) in childhood-onset systemic lupus erythematosus. However, patients who do not respond t...

Authors: Mileka Gilbert, Beatrice Goilav, Joyce J. Hsu, Paul J. Nietert, Esra Meidan, Annabelle Chua, Stacy P. Ardoin, Scott E. Wenderfer, Emily von Scheven and Natasha M. Ruth

Developmentally appropriate transitional care during the Covid-19 pandemic for young people with juvenile-onset rheumatic and musculoskeletal diseases: the rationale for a position statement

The importance of developmentally appropriate transitional care in young people with juvenile-onset rheumatic and musculoskeletal disease is well recognised. The Paediatric Rheumatology European Society (PReS)...

Authors: Janet E. McDonagh, Rachel Tattersall, Jacqui Clinch, Joanne Swan, Helen E. Foster and Liza McCann

Juvenile idiopathic arthritis: from aetiopathogenesis to therapeutic approaches

Juvenile idiopathic arthritis (JIA) is the most common paediatric rheumatological disorder and is classified by subtype according to International League of Associations for Rheumatology criteria. Depending on...

Authors: Lina N. Zaripova, Angela Midgley, Stephen E. Christmas, Michael W. Beresford, Eileen M. Baildam and Rachel A. Oldershaw

Frequency of juvenile idiopathic arthritis and associated uveitis in pediatric rheumatology clinics in Turkey: A retrospective study, JUPITER

Juvenile idiopathic arthritis (JIA), is the most common pediatric rheumatologic disorder with unknown etiology. Currently, no population-based data are available regarding the distribution of categories and fr...

Authors: Sezgin Sahin, Ceyhun Acari, Hafize Emine Sonmez, Fatma Zehra Kilic, Erdal Sag, Hatice Adiguzel Dundar, Amra Adrovic, Selcan Demir, Kenan Barut, Yelda Bilginer, Betul Sozeri, Erbil Unsal, Seza Ozen and Ozgur Kasapcopur

Correction to: Targeted provider education and pre-visit planning increase rates of formal depression screening in childhood-onset SLE

Authors: Evan Mulvihill, Rebecca Furru, Alana Goldstein-Leever, Kyla Driest, Stephanie Lemle, Darby MacDonald, Emily Frost and Vidya Sivaraman

Golimumab in juvenile idiopathic arthritis-associated uveitis unresponsive to Adalimumab

To assess the efficacy of golimumab (GLM) as a treatment option for juvenile idiopathic arthritis (JIA)-associated uveitis refractory to adalimumab (ADA).

Authors: Sofia Lanz, Gerald Seidel and Andrea Skrabl-Baumgartner

Patterns of etanercept use in juvenile idiopathic arthritis in the Childhood Arthritis and Rheumatology Research Alliance Registry

We aimed to characterize etanercept (ETN) use in juvenile idiopathic arthritis (JIA) patients enrolled in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry.

Authors: Timothy Beukelman, Aimee Lougee, Roland A. Matsouaka, David Collier, Dax G. Rumsey, Jennifer Schenfeld, Scott Stryker, Marinka Twilt and Yukiko Kimura

Clinical remission and subsequent relapse in patients with juvenile idiopathic arthritis: predictive factors according to therapeutic approach

Juvenile idiopathic arthritis constitutes a significant cause of disability and quality of life impairment in pediatric and adult patients. The aim of this study was to ascertain clinical remission (CR) and su...

Authors: Mireia Castillo-Vilella, Nuria Giménez, Jose Luis Tandaipan, Salvador Quintana and Consuelo Modesto

Identifying the content and context of pain within paediatric rheumatology healthcare professional curricula in the UK: a summative content analysis

The curriculum for professionals working in paediatric rheumatology should include pain but it is unclear to what extent this currently occurs. The aim of this study was to identify pain-related curriculum con...

Authors: Rebecca Rachael Lee, Janet E. McDonagh, Mark Connelly, Sarah Peters and Lis Cordingley

A qualitative study of risk and resilience in young adult women with a history of juvenile-onset fibromyalgia

Juvenile-onset Fibromyalgia (JFM) is a chronic pain condition characterized by widespread musculoskeletal pain, fatigue, sleep difficulties, mood concerns, and other associated symptoms. Although diagnosed in ...

Authors: Morgan Daffin, Mary K. Lynch-Milder, Robert C. Gibler, Caitlin Murray, Carly M. Green and Susmita Kashikar-Zuck

Favorable outcomes with reduced steroid use in juvenile dermatomyositis

High-intensity glucocorticoid regimens are commonly used to induce and maintain remission in Juvenile Dermatomyositis but are associated with several adverse side-effects. Evidence-based treatment guidelines f...

Authors: Amir B. Orandi, Lampros Fotis, Jamie Lai, Hallie Morris, Andrew J. White, Anthony R. French and Kevin W. Baszis

Immunological repertoire linked to PSTPIP1-associated myeloid-related inflammatory (PAMI) syndrome

Mutations along PSTPIP1 gene are associated to two specific conditions, PAPA syndrome and PAMI syndrome, both autoinflammatory disorders associated to disturbances in cytoskeleton formation. Immunological aspe...

Authors: Leonardo Oliveira Mendonça, Maria Teresa Terreri, Fabiane Mitie Osaku, Samar Freschi Barros, Karen Francine Köhler, Alex Isidoro Prado, Myrthes Toledo Barros, Jorge Kalil and Fabio Fernandes Morato Castro

Comment on: homozygous variant p. Arg90His in NCF1 is associated with early-onset interferonopathy: a case report

Authors: George N. Goulielmos, Maria I. Zervou and Elias Eliopoulos

Correction to: Biologic disease modifying antirheumatic drugs and Janus kinase inhibitors in paediatric rheumatology – what we know and what we do not know from randomized controlled trials

Authors: Tatjana Welzel, Carolyn Winskill, Nancy Zhang, Andreas Woerner and Marc Pfister

Assessment of disease activity using a whole-body MRI derived radiological activity index in chronic nonbacterial osteomyelitis

Based on the recently developed ChRonic nonbacterial Osteomyelitis MRI Scoring tool (CROMRIS), we developed a radiological activity index (RAI-CROMRIS) to obtain a quantification of the overall bone involvemen...

Authors: Martina Capponi, Denise Pires Marafon, Flaminia Rivosecchi, Yongdong Zhao, Manuela Pardeo, Virginia Messia, Laura Tanturri de Horatio, Paolo Tomà, Fabrizio De Benedetti and Antonella Insalaco

Community poverty level influences time to first pediatric rheumatology appointment in Polyarticular Juvenile Idiopathic Arthritis

The impact of social determinants of health on children with polyarticular juvenile idiopathic arthritis (pJIA) is poorly understood. Prompt initiation of treatment for pJIA is important to prevent disease mor...

Authors: Nayimisha Balmuri, William Daniel Soulsby, Victoria Cooley, Linda Gerber, Erica Lawson, Susan Goodman, Karen Onel and Bella Mehta

Leukocytoclastic vasculitis in patients with IL12B or IL12RB1 deficiency: case report and review of the literature

Mendelian susceptibility to mycobacterial disease (MSMD) is an inborn error of immunity, resulting in susceptibility to weakly virulent mycobacteria and other intramacrophagic pathogens. Rheumatologic manifest...

Authors: Niusha Sharifinejad, Seyed Alireza Mahdaviani, Mahnaz Jamee, Zahra Daneshmandi, Afshin Moniri, Majid Marjani, Payam Tabarsi, Parisa Farnia, Mahsa Rekabi, Mazdak Fallahi, Seyedeh Atefeh Hashemimoghaddam, Masoumeh Mohkam, Jacinta Bustamante, Jean-Laurent Casanova, Davood Mansouri and Ali Akbar Velayati

Anasarca as the presenting symptom of juvenile dermatomyositis: a case series

Juvenile Dermatomyositis (JDM) is an autoimmune disease that typically presents with classic skin rashes and proximal muscle weakness. Anasarca is a rare manifestation of this disease and is associated with a ...

Authors: Emily E. Schildt and Deirdre De Ranieri

US NHANES Data 2013–2016: increased risk of severe obesity in individuals with history of juvenile idiopathic arthritis

Authors: Stephanie Merwin, Eleanor Mackey and Sangeeta Sule

Changes in total body fat and body mass index among children with juvenile dermatomyositis treated with high-dose glucocorticoids

High-dose glucocorticoids (GC) remain the primary therapy to induce remission in Juvenile Dermatomyositis (JDM). Studies of the natural history of GC associated weight gain in children are very limited, especi...

Authors: Amer Khojah, Victoria Liu, Gabrielle Morgan, Richard M. Shore and Lauren M. Pachman

Sarcoidosis presenting as bilateral lacrimal gland swelling: a pediatric case report

To describe a case of pediatric sarcoidosis which initially presented as papillary conjunctivitis before manifesting as bilateral lacrimal gland swelling without other known systemic involvement.

Authors: Margaret S. Powell, Ashley W. Cross, Jared Tallo, Edward W. Cheeseman and Mileka R. Gilbert

Targeted provider education and pre-visit planning increase rates of formal depression screening in childhood-onset SLE

Despite being at high risk for depression, patients with childhood-onset systemic lupus erythematosus (c-SLE) are infrequently and inconsistently screened for depression by their pediatric rheumatologists. We ...

Authors: Evan Mulvihill, Rebecca Furru, Alana Goldstein-Leever, Kyla Driest, Stephanie Lemle, Darby MacDonald, Emily Frost and Vidya Sivaraman

Correction to: Juvenile idiopathic arthritis in Harlequin ichthyosis, a rare combination or the clinical spectrum of the disease? Report of a child treated with etanercept and review of the literature

Authors: Francesco Baldo, Michela Brena, Simone Carbogno, Francesca Minoia, Stefano Lanni, Sophie Guez, Antonella Petaccia, Carlo Agostoni, Rolando Cimaz and Giovanni Filocamo

Diffuse alveolar hemorrhage in children with trisomy 21

Respiratory conditions are the leading cause of hospitalization and death in children with Trisomy 21 (T21). Diffuse alveolar hemorrhage (DAH) occurs at higher frequency in children with T21; yet, it is not wi...

Authors: Jessica L. Bloom, Benjamin Frank, Jason P. Weinman, Csaba Galambos, Sean T. O’Leary, Deborah R. Liptzin and Robert C. Fuhlbrigge

Lost bones: differential diagnosis of acro-osteolysis seen by the pediatric rheumatologist

Acro-osteolysis is a radiographic finding which refers to bone resorption of the distal phalanges. Acro-osteolysis is associated with various conditions and its presence should prompt the clinician to search f...

Authors: Elizaveta Limenis, Jennifer Stimec, Peter Kannu and Ronald M. Laxer

Association between high mobility group box 1 protein and juvenile idiopathic arthritis: a prospective longitudinal study

To analyze the levels of high mobility group box 1 (HMGB1) protein on different courses of juvenile idiopathic arthritis (JIA).

Authors: Dan Xu, Yu Zhang, Zhi-Yong Zhang and Xue-Mei Tang

Reducing fatigue in pediatric rheumatic conditions: a systematic review

Although fatigue is a prevalent distressing symptom in children and adolescents with Pediatric Rheumatic Conditions (PRCs), intervention studies designed for reducing fatigue in PRCs are limited.

Authors: K. Kant-Smits, M. Van Brussel, S. Nijhof and J. Van der Net

Development and validation of the Sorting non-trauMatIc adoLescent knEe pain (SMILE) tool – a development and initial validation study

Despite the commonality of adolescent knee pain, there are no tools to support medical doctors to correctly diagnose knee pain. This study aimed to develop and evaluate a support tool for diagnosing the most c...

Authors: Clara Guldhammer, Sinead Holden, Marina Elmelund Sørensen, Jens Lykkegaard Olesen, Martin Bach Jensen and Michael Skovdal Rathleff

Effect of first-line biologic initiation on glucocorticoid exposure in children hospitalized with new-onset systemic juvenile idiopathic arthritis: emulation of a pragmatic trial using observational data

Glucocorticoid exposure is a significant driver of morbidity in children with systemic juvenile idiopathic arthritis (sJIA). We determined the effect of early initiation of biologic therapy (IL-1 or IL-6 inhib...

Authors: Rosemary G. Peterson, Rui Xiao, Hannah Katcoff, Brian T. Fisher and Pamela F. Weiss

The vaccine coverage and vaccine immunity status and risk factors of non-protective levels of antibodies against vaccines in children with juvenile idiopathic arthritis: cross-sectional Russian tertiary Centre study

Immunosuppressive drugs, incomplete vaccine coverage, immune system dysregulation might be factors of a low level of anti-vaccine antibodies in JIA patients. The study aimed to evaluate vaccine coverage, post-...

Authors: Mikhail M. Kostik, Natalia A. Lubimova, Irina V. Fridman, Olga V. Goleva and Susanna M. Kharit

Efficacy and safety associated with the infusion speed of intravenous immunoglobulin for the treatment of Kawasaki disease: a randomized controlled trial

High-dose intravenous immunoglobulin (IVIG) is the mainstay of treatment for Kawasaki disease (KD). Usually, 2 g/kg of IVIG is administered over 10–24 h, depending on the institution or physician, but the asso...

Authors: Saori Fukui, Mitsuru Seki, Takaomi Minami, Kazuhiko Kotani, Kensuke Oka, Akiko Yokomizo, Daisuke Matsubara, Tomoyuki Sato, Yasuyuki Nozaki, Mari Saito, Yutaka Kikuchi, Kenji Miyamoto, Yukifumi Monden and Takanori Yamagata

Mandibular range of motion in children with juvenile idiopathic arthritis with and without clinically established temporomandibular joint involvement and in healthy children; a cross-sectional study

Recognition of temporomandibular joint (TMJ) involvement in children with juvenile idiopathic arthritis (JIA) has gained increasing attention in the past decade. The clinical assessment of mandibular range of ...

Authors: Willemijn F. C. de Sonnaville, Caroline M. Speksnijder, Nicolaas P. A. Zuithoff, Daan R. C. Verkouteren, Nico W. Wulffraat, Michel H. Steenks and Antoine J. W. P. Rosenberg

Psychiatric disorders in incident patients with juvenile idiopathic arthritis - a case-control cohort study

Chronic illness, such as juvenile idiopathic arthritis (JIA), appears to have an impact on the mental health of children and adolescents. The aim of this study was to explore the incidence of mental and behavi...

Authors: Minna S. Kyllönen, Hanna Ebeling, Hannu Kautiainen, Kari Puolakka and Paula Vähäsalo

Patient with H syndrome, cardiogenic shock, multiorgan infiltration, and digital ischemia

H syndrome (HS) is a rare autoinflammatory disease caused by a mutation in the solute carrier family 29, member 3 (SCL29A3) gene. It has a variable clinical presentation and little phenotype-genotype correlati...

Authors: Laura Ventura-Espejo, Inés Gracia-Darder, Silvia Escribá-Bori, Eva Regina Amador-González, Ana Martín-Santiago and Jan Ramakers

Adolescent-onset anti-MDA5 antibody-positive juvenile dermatomyositis with rapidly progressive interstitial lung disease and spontaneous pneumomediastinum: a case report and literature review

Dermatomyositis with positive anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody has a distinct phenotype associated with small hand joint arthritis, mucocutaneous ulceration, palmar papules ...

Authors: Tsz-Wing Yeung, Kai-Ning Cheong, Yu-Lung Lau and Kei-Chiu Niko Tse

A cross-sectional cohort study of the activity and turnover of neutrophil granulocytes in juvenile idiopathic arthritis

The inflammatory process in juvenile idiopathic arthritis (JIA) involves both the innate and the adaptive immune system. The turnover and activity of neutrophil granulocytes may be reflected by proteins secret...

Authors: Malin Backlund, Per Venge and Lillemor Berntson

Assessment of transition readiness in adolescents in Thailand with rheumatic diseases: a cross-sectional study

Most childhood-onset rheumatic diseases are chronic health conditions, which need long-term care throughout adulthood. A well-organized transition care is challenging and patient assessment of transition skill...

Authors: Sirinthip Kittivisuit, Butsabong Lerkvaleekul, Sirisucha Soponkanaporn, Pintip Ngamjanyaporn and Soamarat Vilaiyuk

A case of dermatomyositis in a patient with central core disease: unusual association with autoimmunity and genetic muscle disease

Dermatomyositis is an inflammatory muscle disease caused by immune-mediated muscle injury, and central core disease (CCD) is a congenital myopathy associated with disturbed intracellular calcium homeostasis an...

Authors: Min Jung Kim, Mi Hyeon Kim, Sung-Hye Park and Yeong Wook Song

Cutaneous mucinosis of infancy: a rare case of joint involvement

Primary cutaneous mucinosis are a heterogeneous group of diseases characterized by the deposition of glycosaminoglycans in the dermis and the follicles. These diseases are rare in children therefore their diag...

Authors: Cristina Morreale, Dario Bleidl, Angela Rita Sementa and Clara Malattia

Intravenous administration of anakinra in children with macrophage activation syndrome

Subcutaneous anakinra is an interleukin-1 inhibitor used to treat juvenile idiopathic arthritis. Recent reports suggest anakinra can be a valuable addition to the treatment of COVID-19 associated cytokine stor...

Authors: Omkar Phadke, Kelly Rouster-Stevens, Helen Giannopoulos, Shanmuganathan Chandrakasan and Sampath Prahalad

Clinical and psychosocial stress factors are associated with decline in physical activity over time in children with juvenile idiopathic arthritis

Physical activity (PA) patterns in children with juvenile idiopathic arthritis (JIA) over time are not well described. The aim of this study was to describe associations of physical activity (PA) with disease ...

Authors: Liane D. Heale, Kristin M. Houghton, Elham Rezaei, Adam D. G. Baxter-Jones, Susan M. Tupper, Nazeem Muhajarine, Susanne M. Benseler, Gilles Boire, David A. Cabral, Sarah Campillo, Gaëlle Chédeville, Anne-Laure Chetaille, Paul Dancey, Ciaran Duffy, Karen Watanabe Duffy, Janet Ellsworth…

Factors affecting the duration of coronary artery lesions in patients with the Kawasaki disease: a retrospective cohort study

Coronary artery lesions (CALs) are the most severe complication of Kawasaki disease (KD). Approximately 9–20% of the patients with KD develop CAL despite receiving regular treatment (intravenous immunoglobulin...

Authors: Xuting Zhang, Yuee He, Yiping Shao, Biyao Hang, Zhipeng Xu and Maoping Chu