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  1. Content type: Research article

    The etiology of Kawasaki disease (KD) is still unknown; perinatal factors may have role with few studies. This study was aim to survey the perinatal factors and clinical outcome of KD, including coronary arter...

    Authors: Wei-Dong Huang, Yu-Ting Lin, Zi-Yu Tsai, Ling-Sai Chang, Shih-Feng Liu, Yi-Ju Lin and Ho-Chang Kuo

    Citation: Pediatric Rheumatology 2019 17:46

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  2. Content type: Research article

    Chronic non-bacterial osteomyelitis (CNO) is an autoinflammatory disorder of the skeletal system of yet unknown etiology. Patients present with local bone pain and inflammation and - to our experience - often ...

    Authors: Nentwich Julia, Ruf Katharina, Girschick Hermann, Holl-Wieden Annette, Morbach Henner, Hebestreit Helge and Hofmann Christine

    Citation: Pediatric Rheumatology 2019 17:45

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  3. Content type: Research article

    The aim of the study was to describe school attendance and participation in physical education in school among children with juvenile idiopathic arthritis (JIA).

    Authors: Ellen Nordal, Veronika Rypdal, Ellen Dalen Arnstad, Kristiina Aalto, Lillemor Berntson, Maria Ekelund, Anders Fasth, Mia Glerup, Troels Herlin, Susan Nielsen, Suvi Peltoniemi, Marek Zak, Nils Thomas Songstad and Marite Rygg

    Citation: Pediatric Rheumatology 2019 17:44

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  4. Content type: Research article

    We designed and initiated a pilot comparative effectiveness study for juvenile localized scleroderma (jLS), for which there is limited evidence on best therapy. We evaluated the process we used, in relation to...

    Authors: Suzanne C. Li, Robert C. Fuhlbrigge, Ronald M. Laxer, Elena Pope, Maria F. Ibarra, Katie Stewart, Thomas Mason II, Mara L. Becker, Sandy Hong, Fatma Dedeoglu, Kathryn S. Torok, C. Egla Rabinovich, Polly J. Ferguson, Marilynn Punaro, Brian M. Feldman, Tracy Andrews…

    Citation: Pediatric Rheumatology 2019 17:43

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  5. Content type: Research article

    Intraarticular corticosteroid injection (IACI) is one of the most common treatments in oligoarticular Juvenile Idiopathic Arthritis (JIA). Activity recommendations following injection vary, as there are no pub...

    Authors: Elaine R. Flanagan, Heather Benham, Janet Figueroa, Janille Diaz, Jenna Tress and David D. Sherry

    Citation: Pediatric Rheumatology 2019 17:42

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  6. Content type: Research article

    The pathology of juvenile dermatomyositis (JDM) is characterized by prominent vessel wall and perivascular inflammation. This feature of the disease has remained unexplained and under-investigated. We have hyp...

    Authors: Kaiyu Jiang, Rie Karasawa, Zihua Hu, Yanmin Chen, Lucy Holmes, Kathleen M. O’Neil and James N. Jarvis

    Citation: Pediatric Rheumatology 2019 17:41

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  7. Content type: Review

    Juvenile Idiopathic Arthritis associated Uveitis (JIA-U) represents its most frequent extra-articular manifestation and the main cause of childhood uveitis in in developed countries. The broad variety of outco...

    Authors: Greta Mastrangelo, Ivan Foeldvari, Jordi Anton and Gabriele Simonini

    Citation: Pediatric Rheumatology 2019 17:40

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  8. Content type: Case Report

    Deficiency of adenosine deaminase 2 (DADA2) is a rare autosomal recessive autoinflammatory condition. Recognised features include vasculitis predominantly affecting medium sized vessels, livedoid skin rash, ce...

    Authors: Katherine Clarke, Cathy Campbell, Ebun Omoyinmi, Ying Hong, Muthana Al Obaidi, Neil Sebire and Paul A. Brogan

    Citation: Pediatric Rheumatology 2019 17:39

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  9. Content type: Case Report

    Autosomal dominant gain of function mutations in caspase recruitment domain family member 14 (CARD14) is a rare condition associated with plaque-type psoriasis, generalized pustular psoriasis, palmoplantar pus...

    Authors: S. Signa, E. Campione, M. Rusmini, S. Chiesa, A. Grossi, A. Omenetti, R. Caorsi, G. M. Viglizzo, M. Galluzzo, L. Bianchi, M. Talamonti, A. Orlandi, A. Martini, I. Ceccherini and M. Gattorno

    Citation: Pediatric Rheumatology 2019 17:38

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  10. Content type: Review

    Deficiency of interleukin-36 receptor antagonist (DITRA) is a life threatening monogenic autoinflammatory disease caused by loss of function mutations in the IL36RN gene. Affected patients develop recurrent episo...

    Authors: Toni Hospach, Fabian Glowatzki, Friederike Blankenburg, Dennis Conzelmann, Christian Stirnkorb, Chris Sandra Müllerschön, Peter von den Driesch, Lisa Maria Köhler, Meino Rohlfs, Christoph Klein and Fabian Hauck

    Citation: Pediatric Rheumatology 2019 17:37

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  11. Content type: Research article

    Cryopyrin-associated periodic syndrome (CAPS) is a rare autoinflammatory disease, caused by gain of function mutation in NLRP3 resulting in excess production of interleukin-1 (IL-1). Canakinumab is a human monocl...

    Authors: Abdulkadir A. Elmi, Karen Wynne, Iek L. Cheng, Despina Eleftheriou, Helen J. Lachmann, Philip N. Hawkins and Paul Brogan

    Citation: Pediatric Rheumatology 2019 17:36

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  12. Content type: Research article

    Kawasaki disease (KD) is a systemic vasculitis which may be associated with coronary artery aneurysms. A notable risk factor for the development of coronary artery aneurysms is resistance to intravenous immuno...

    Authors: Yuji Amano, Yohei Akazawa, Jun Yasuda, Kazuhisa Yoshino, Katsuhiko Kojima, Norimoto Kobayashi, Satoshi Matsuzaki, Masao Nagasaki, Yosuke Kawai, Naoko Minegishi, Noriko Ishida, Noriko Motoki, Akira Hachiya, Yozo Nakazawa, Masayuki Yamamoto, Kenichi Koike…

    Citation: Pediatric Rheumatology 2019 17:34

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  13. Content type: Research article

    The etiology of Juvenile Idiopathic Arthritis (JIA) is poorly understood. The purpose of this study was to examine the possible influence of early nutrition on later development of JIA.

    Authors: Erik Kindgren, Carlos Guerrero-Bosagna and Johnny Ludvigsson

    Citation: Pediatric Rheumatology 2019 17:33

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  14. Content type: Research article

    Childhood-onset systemic erythematosus lupus (cSLE) is characterized by more severe disease, widespread organ involvement and higher mortality compared to adult-onset SLE. However, cSLE is largely underfunded ...

    Authors: Stacy P. Ardoin, R Paola Daly, Lyna Merzoug, Karin Tse, Kaveh Ardalan, Lisa Arkin, Andrea Knight, Tamar Rubinstein, Natasha Ruth, Scott E. Wenderfer and Aimee O. Hersh

    Citation: Pediatric Rheumatology 2019 17:32

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  15. Content type: Review

    Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) refers to a complex group of systemic vasculitides that are characterized by primary small-to-medium sized blood vessel inflammation with...

    Authors: Jennifer J. Y. Lee, Alhanouf Alsaleem, Grace P. K. Chiang, Elizaveta Limenis, Watchareewan Sontichai, Rae S. M. Yeung, Jonathan Akikusa and Ronald M. Laxer

    Citation: Pediatric Rheumatology 2019 17:31

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  16. Content type: Research article

    Juvenile Dermatomyositis is a rare, potentially life-threatening condition with no known cure. There is no published literature capturing how children and young people feel about their condition, from their pe...

    Authors: Polly Livermore, Suzanne Gray, Kathleen Mulligan, Jennifer N. Stinson, Lucy R. Wedderburn and Faith Gibson

    Citation: Pediatric Rheumatology 2019 17:30

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  17. Content type: Research article

    Relapsing periodic arthritis is a general term used for a group of diseases with recurring and periodic nature, in which the joints are intermittently involved. The aim of this study is to evaluation of the po...

    Authors: Farhad Salehzadeh, Manuchehr Barak and Roghayeh Nematdoust Haghi

    Citation: Pediatric Rheumatology 2019 17:28

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  18. Content type: Research article

    Currently, there are no medications approved for the treatment of juvenile fibromyalgia (JFM). We evaluated the safety and efficacy of duloxetine 30/60 mg once daily (QD) versus placebo in adolescents with JFM.

    Authors: Himanshu P. Upadhyaya, Lesley M. Arnold, Karla Alaka, Meihua Qiao, David Williams and Renata Mehta

    Citation: Pediatric Rheumatology 2019 17:27

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  19. Content type: Case Report

    Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare systemic vasculitis in children. A delayed or missed diagnosis of pediatric EGPA is common, owing to the atypical clinical manifestation and limit...

    Authors: Xiaoliang Liu, Lin Wang, Kaiyu Zhou, Yimin Hua, Xiaoqing Shi and Chuan Wang

    Citation: Pediatric Rheumatology 2019 17:26

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  20. Content type: Short Report

    Systemic juvenile idiopathic arthritis (sJIA) is an inflammatory condition that presents with fever, rash and arthritis. At onset systemic features are predominant and the diagnosis may be a challenge. Seconda...

    Authors: Alessia Arduini, Emiliano Marasco, Giulia Marucci, Manuela Pardeo, Antonella Insalaco, Ivan Caiello, Gian Marco Moneta, Giusi Prencipe, Fabrizio De Benedetti and Claudia Bracaglia

    Citation: Pediatric Rheumatology 2019 17:25

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  21. Content type: Research article

    Prednisone (PDN) in juvenile dermatomyositis (JDM), alone or in association with other immunosuppressive drugs, namely methotrexate (MTX) and cyclosporine (CSA), represents the first-line treatment option for ...

    Authors: Gabriella Giancane, Claudio Lavarello, Angela Pistorio, Sheila K. Oliveira, Francesco Zulian, Ruben Cuttica, Michel Fischbach, Bo Magnusson, Serena Pastore, Roberto Marini, Silvana Martino, Anne Pagnier, Christine Soler, Valda Staņēvicha, Rebecca Ten Cate, Yosef Uziel…

    Citation: Pediatric Rheumatology 2019 17:24

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  22. Content type: Research article

    Young people (YP; 12–24 years old) with rheumatic diseases face many challenges associated with chronic illness in addition to the physiological and psychosocial changes of adolescence. Timely access to develo...

    Authors: Ran A. Cai, Hema Chaplin, Polly Livermore, Martin Lee, Debajit Sen, Lucy R. Wedderburn, Nick Wilkinson, Rachel Jeffery, Andrea Kempa, Imogen Norton, Rachel Tattersall, Yiannis Ioannou and Despina Eleftheriou

    Citation: Pediatric Rheumatology 2019 17:23

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  23. Content type: Review

    Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory disease in Canada and is characterized by a clinical syndrome of episodic inflammatory symptoms. Traditionally, the disease is d...

    Authors: Clara Westwell-Roper, Iwona Niemietz, Lori B. Tucker and Kelly L. Brown

    Citation: Pediatric Rheumatology 2019 17:22

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  24. Content type: Review

    This study aims to describe current practice in identifying and measuring health care resource use and unit costs in economic evaluations or costing studies of juvenile idiopathic arthritis (JIA).

    Authors: Michelle M. A. Kip, Gillian Currie, Deborah A. Marshall, Luiza Grazziotin Lago, Marinka Twilt, Sebastiaan J. Vastert, Joost F. Swart, Nico Wulffraat, Rae S. M. Yeung, Susanne M. Benseler and Maarten J. IJzerman

    Citation: Pediatric Rheumatology 2019 17:20

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  25. Content type: Case Report

    CANDLE syndrome (an acronym for Chronic Atypical Neutrophilic Dermatosis with Lipodystrophy and Elevated Temperature) is a recently described rare autosomal recessive disorder charaterized by systemic autoinfl...

    Authors: M. Boyadzhiev, L. Marinov, V. Boyadzhiev, V. Iotova, I. Aksentijevich and S. Hambleton

    Citation: Pediatric Rheumatology 2019 17:19

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  26. Content type: Research article

    To investigate efficacy and safety of intravenous abatacept in Japanese patients with active polyarticular-course juvenile idiopathic arthritis (pJIA).

    Authors: Ryoki Hara, Hiroaki Umebayashi, Syuji Takei, Nami Okamoto, Naomi Iwata, Yuichi Yamasaki, Yasuo Nakagishi, Toshitaka Kizawa, Ichiro Kobayashi, Tomoyuki Imagawa, Noriko Kinjo, Norihito Amano, Yoko Takahashi, Masaaki Mori, Yasuhiko Itoh and Shumpei Yokota

    Citation: Pediatric Rheumatology 2019 17:17

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  27. Content type: Research article

    Not all physical activity (PA) questionnaires (PAQ) gather information regarding PA intensity, duration, and modes and only a few were developed specifically for children. We assessed children’s comprehensibil...

    Authors: August Flodén, Eva W. Broström, Johan von Heideken, Sara Rostlund, Rikard Nilsson, Kristina Löwing and Maura D. Iversen

    Citation: Pediatric Rheumatology 2019 17:16

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  28. Content type: Research article

    Although there are many reports on Juvenile Idiopathic arthritis-associated uveitis (JIA-U) from various countries, especially from Europe and North America, there are few reports from Asia. Our aim was to inv...

    Authors: Junko Yasumura, Masato Yashiro, Nami Okamoto, Kosuke Shabana, Hiroaki Umebayashi, Naomi Iwata, Yuka Okura, Tomohiro Kubota, Masaki Shimizu, Minako Tomiita, Yasuo Nakagishi, Kenichi Nishimura, Ryoki Hara, Mao Mizuta, Takahiro Yasumi, Fumiya Yamaide…

    Citation: Pediatric Rheumatology 2019 17:15

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  29. Content type: Research article

    Poor cardiorespiratory fitness is previously reported in patients with juvenile idiopathic arthritis (JIA) measured both by maximal and submaximal exercise tests, but a submaximal exercise test with acceptable...

    Authors: Kristine Risum, Elisabeth Edvardsen, Anne M. Selvaag, Hanne Dagfinrud and Helga Sanner

    Citation: Pediatric Rheumatology 2019 17:14

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  30. Content type: Research article

    Kawasaki disease (KD) is the most common acute coronary vasculitis disease to occur in children. Its incidence has been attributed to the combined effects of infection, genetics, and immunity. Although the eti...

    Authors: Ying-Hsien Huang, Mao-Hung Lo, Xin-Yuan Cai, Shih-Feng Liu and Ho-Chang Kuo

    Citation: Pediatric Rheumatology 2019 17:13

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  31. Content type: Research article

    Rheumatic heart disease (RHD) is a chronic condition responsible of congestive heart failure, stroke and arrhythmia. Almost eradicated in high-income countries (HIC), it persists in low- and middle-income coun...

    Authors: Fortunata Condemi, Gabriele Rossi, Miguel Lupiz, Antonio Pagano, Federica Zamatto, Stefano Marini, Francesco Romeo and Gianfranco De Maio

    Citation: Pediatric Rheumatology 2019 17:12

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  32. Content type: Research article

    Intra-articular corticosteroid injections (IACI) are frequently used in the treatment of juvenile idiopathic arthritis. There is a paucity of evidence-based research describing methods of pain and anxiety cont...

    Authors: Rotem Elitsur, April Hollenbeck, Laura Tasan, Kathryn S. Torok, Elaine Cassidy, Brian Blasiole, Erika Parsons, Chelsea Acock, Joseph Angelelli and Isabela-Cajiao Angelelli

    Citation: Pediatric Rheumatology 2019 17:11

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  33. Content type: Review

    Nephritis is the most important chronic complication of IgA Vasculitis (IgAV)/Henoch-Schönlein purpura (IGAV/HSP) and thus the main prognostic factor of this most common childhood vasculitis. Since the prognos...

    Authors: Marija Jelusic, Mario Sestan, Rolando Cimaz and Seza Ozen

    Citation: Pediatric Rheumatology 2019 17:10

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  34. Content type: Research article

    To develop and test the feasibility and initial effectiveness of the Treatment and Education Approach for Childhood-onset Lupus (TEACH) protocol, a 6-session cognitive behavioral therapy (CBT) intervention for...

    Authors: Natoshia R. Cunningham, Lauren M. Fussner, Erin Moorman, Pinar O. Avar Aydin, Hermine I. Brunner and Susmita Kashikar-Zuck

    Citation: Pediatric Rheumatology 2019 17:9

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  35. Content type: Case Report

    Anti-NMDA receptor encephalitis, an autoimmune disease associated with antibodies against N-methyl-D-aspartate (NMDA) receptors, is being diagnosed more frequently, especially in children and young adults. Acu...

    Authors: Taha Moussa, Khalid Afzal, Joseph Cooper, Ryan Rosenberger, Karyn Gerstle and Linda Wagner-Weiner

    Citation: Pediatric Rheumatology 2019 17:8

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  36. Content type: Research article

    Hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) were historically thought to be distinct entities, often managed in isolation. In fact, these conditions are closely related. A...

    Authors: Olha Halyabar, Margaret H. Chang, Michelle L. Schoettler, Marc A. Schwartz, Ezgi H. Baris, Leslie A. Benson, Catherine M. Biggs, Mark Gorman, Leslie Lehmann, Mindy S. Lo, Peter A. Nigrovic, Craig D. Platt, Gregory P. Priebe, Jared Rowe, Robert P. Sundel, Neeraj K. Surana…

    Citation: Pediatric Rheumatology 2019 17:7

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  37. Content type: Research article

    Regular school sports can help adolescents achieve the recommended amount of daily physical activity and provide knowledge, attitudes and behavioral skills that are needed in order to adopt and maintain a phys...

    Authors: Florian Milatz, Jens Klotsche, Martina Niewerth, Nils Geisemeyer, Ralf Trauzeddel, Elisabeth Weißbarth-Riedel, Tilmann Kallinich, Joachim Peitz, Matthias Hartmann and Kirsten Minden

    Citation: Pediatric Rheumatology 2019 17:6

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  38. Content type: Research article

    Of 37 pediatric rheumatology fellowship training programs in the United States, many have three or fewer fellows at a given time, making large-scale assessment of fellow performance difficult. An objective str...

    Authors: Megan L. Curran, Emma E. Martin, Erin C. Thomas, Rashmi Singh, Saima Armana, Asnia Kauser, Eesha A. Zaheer and David D. Sherry

    Citation: Pediatric Rheumatology 2019 17:5

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  39. Content type: Review

    Juvenile Idiopathic arthritis (JIA) is the most common chronic rheumatic disease in childhood. The diagnosis is based on the underlying symptoms of arthritis with an exclusion of other diseases Biologic agents...

    Authors: Arnold Nagy, Péter Mátrai, Péter Hegyi, Hussain Alizadeh, Judit Bajor, László Czopf, Zoltán Gyöngyi, Zoltán Kiss, Katalin Márta, Mária Simon, Ágnes Lilla Szilágyi, Gábor Veres and Bernadett Mosdósi

    Citation: Pediatric Rheumatology 2019 17:4

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  40. Content type: Research article

    Joint hypermobility is common in childhood and can be associated with musculoskeletal pain and dysfunction. Current management is delivered by a multidisciplinary team, but evidence of effectiveness is limited...

    Authors: Peter Bale, Vicky Easton, Holly Bacon, Emma Jerman, Laura Watts, Garry Barton, Allan Clark, Kate Armon and Alex J. MacGregor

    Citation: Pediatric Rheumatology 2019 17:2

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  41. Content type: Research article

    As an acute febrile and inflammatory disease, Kawasaki disease (KD) could develop Kawasaki disease shock syndrome (KDSS) sometimes. However its pathogenesis was still not well known. This study was to learn mo...

    Authors: Yandie Li, Qi Zheng, Lixia Zou, Jianqiang Wu, Li Guo, Liping Teng, Rongjun Zheng, Lawrence Kwok Leung Jung and Meiping Lu

    Citation: Pediatric Rheumatology 2019 17:1

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  42. Content type: Short report

    The data on cardiovascular risk and systemic arterial properties in patients with long-lasting juvenile idiopathic arthritis (JIA) is limited. The objective of this study was to describe systemic arterial prop...

    Authors: Hanne Aaserud Aulie, Mette-Elise Estensen, Anne Marit Selvaag, Vibke Lilleby, Berit Flatø and Svend Aakhus

    Citation: Pediatric Rheumatology 2018 16:85

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  43. Content type: Research article

    Few risk factors have been identified for the development of calcinosis among patients with Juvenile Dermatomyositis, and currently no clinical phenotype has been associated with its development. We analyzed a...

    Authors: Amir B. Orandi, Vikas R. Dharnidharka, Noor Al-Hammadi and Kevin W. Baszis

    Citation: Pediatric Rheumatology 2018 16:84

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  44. Content type: Research article

    Current management guidelines for patients with Kawasaki disease (KD) differ in their recommendations for fever observation times when determining resistance to initial intravenous immunoglobulin (IVIG). This ...

    Authors: Jae Suk Baek, Jeong Jin Yu, Mi Jin Kim, Jihye You, Hyun Ok Jun, Young-Hwue Kim and Jae-Kon Ko

    Citation: Pediatric Rheumatology 2018 16:83

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  45. Content type: Research article

    Juvenile idiopathic arthritis (JIA) is the most common chronic, systemic autoimmune connective tissue disease diagnosed in children and adolescents. An important aspect of monitoring of children with JIA is a ...

    Authors: Paweł Więch, Izabela Sałacińska, Dariusz Bazaliński and Mariusz Dąbrowski

    Citation: Pediatric Rheumatology 2018 16:82

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