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  1. Pediatric uveitis is a severe inflammatory ocular condition that can lead to sight-threatening complications and can negatively impact quality of life. The retinal microcirculation is often affected in interme...

    Authors: Carlyn V. Kouwenberg, Julia Spierings, Evianne L. de Groot, Joke H. de Boer and Viera Kalinina Ayuso
    Citation: Pediatric Rheumatology 2023 21:109
  2. The objective of this initiative was to develop a treat-to-target (T2T) approach for the management of patients with Familial Mediterranean Fever (FMF), including the definition of a complex treatment target, ...

    Authors: Lisa Ehlers, Elisabeth Rolfes, Mareike Lieber, Dominik Müller, Elke Lainka, Faekah Gohar, Günter Klaus, Hermann Girschick, Jana Hörstermann, Jasmin Kümmerle-Deschner, Jürgen Brunner, Katharina Palm-Beden, Klaus Tenbrock, Lusine von Wrangel, Maria Faßhauer, Norbert Blank…
    Citation: Pediatric Rheumatology 2023 21:108
  3. In juvenile idiopathic arthritis (JIA) clinical remission is unattainable in some patients despite modern biologic disease-modifying antirheumatic drugs (bDMARD) therapy and switching bDMARD is required. The b...

    Authors: Mia Lindegaard Pedersen, Amalie Neve-Græsbøll, Troels Herlin and Mia Glerup
    Citation: Pediatric Rheumatology 2023 21:107
  4. Macrophage activation syndrome (MAS) is a severe and life-threatening syndrome associated with autoimmune diseases. The coexistence of MAS and juvenile dermatomyositis (JDM) is not well reported. This report d...

    Authors: Yong Chang, Xueyan Shan and Yongpeng Ge
    Citation: Pediatric Rheumatology 2023 21:106
  5. Musculoskeletal ultrasound is a well accessible technique to assess disease activity in children with juvenile idiopathic arthritis. Knowledge of reference values of joint structures is indispensable to differ...

    Authors: Ruth Wittoek, Céline Decock, Nele Dewaele, Lara Arnold, Pieter Baeyens, Ignace De Schrijver, Lisa Pardaens, Ioannis Raftakis, Thomas Renson, Charline Rinkin, Alexander D. J. Thooft, Tine Vanhaverbeke and Caroline Verbist
    Citation: Pediatric Rheumatology 2023 21:105
  6. Juvenile dermatomyositis (jDM) is the most common idiopathic inflammatory myopathy of childhood. Amyopathic or hypomyopathic courses have been described.

    Authors: Timmy Strauss, Claudia Günther, Anja Schnabel, Christine Wolf, Gabriele Hahn, Min Ae Lee-Kirsch and Normi Brück
    Citation: Pediatric Rheumatology 2023 21:104
  7. Paediatric rheumatic diseases cause considerable disease burden to children and their families (Moorthy LN, Peterson MGE, Hassett AL, et al, Pediatric Rheumatology 8:20, 2010). Delayed diagnosis is a significa...

    Authors: Jacqueline E. Kawishe, Anthony Ngugi, Stanley Luchters, Helen Foster and Angela Migowa
    Citation: Pediatric Rheumatology 2023 21:103
  8. To identify baseline predictors of persisting pain in children with Juvenile Idiopathic Arthritis (JIA), relative to patients with JIA who had similar baseline levels of pain but in whom the pain did not persist.

    Authors: Tara McGrath, Jaime Guzman, Lori Tucker, Natalie J. Shiff, Maryna Yaskina, Susan Tupper and Dax G. Rumsey
    Citation: Pediatric Rheumatology 2023 21:102
  9. Sweet syndrome (SS), also known as acute febrile neutrophilic dermatosis, is an immunologic syndrome characterized by widespread neutrophilic infiltration. Histiocytoid Sweet syndrome (H-SS) is a histopatholog...

    Authors: Margaret Irwin, Veeraya K. Tanawattanacharoen, Amy Turner, Mary Beth F. Son, Rebecca C. Hale, Craig D. Platt, Juan Putra, Birgitta A.R. Schmidt and Mollie G. Wasserman
    Citation: Pediatric Rheumatology 2023 21:101
  10. Throughout the COVID-19 pandemic, there have been concerns regarding the risks of infection in patients with autoimmune disease. In this study, we investigated the impact of the pandemic on patients with juven...

    Authors: Dawn M. Wahezi, Dominique Jerome, Evin Rothschild, Belina Yi, Jeffrey Dvergsten, Stacey Tarvin, Susan Kim and Tamar Rubinstein
    Citation: Pediatric Rheumatology 2023 21:100
  11. Tocilizumab is a humanized monoclonal antibody that acts as an IL-6 receptor antagonist. Intravenous tocilizumab is considered an option for children with anti-TNF refractory juvenile idiopathic arthritis-asso...

    Authors: Francesca Burlo, Cristina Tumminelli, Serena Pastore, Gabriele Stocco, Debora Curci, Marianna Lucafò, Alberto Tommasini and Andrea Taddio
    Citation: Pediatric Rheumatology 2023 21:99
  12. Systemic juvenile idiopathic arthritis (systemic JIA) is a severe disease with both systemic and joint inflammation. This study aims to identify predictors of disease evolution within the systemic JIA populati...

    Authors: M. Wallimann, K. Bouayed, E. Cannizzaro, D. Kaiser, A. Belot, E. Merlin, S. Poignant, C. Wouters, F. Hofer, T. Saurenmann, A. Koryllou, R. Carlomagno, M. Mejbri, M. Hofer and K. Theodoropoulou
    Citation: Pediatric Rheumatology 2023 21:96
  13. Although the advent of new therapeutics for juvenile idiopathic arthritis (JIA) patients has considerably lessened the impact of the disease and reduced its sequelae, the outcomes of JIA remain important in th...

    Authors: Carine Savel, Aurélie Chausset, Pauline Berland, Candy Guiguet-Auclair, Laura Cabane, Bruno Fautrel, Philippe Gaudin, Pascale Guillot, Gilles Hayem, Delphine Lafarge, Etienne Merlin, Nadine Pezière, Christelle Sordet, Sonia Trope, Anne Tournadre, Sandrine Malochet…
    Citation: Pediatric Rheumatology 2023 21:95
  14. The aim of this long-term follow-up study was to compare the disease characteristics of HLA-B27 positive and negative patients with juvenile idiopathic arthritis (JIA).

    Authors: Suvi Oili Orvokki Peltoniemi, Mia Glerup, Pekka Lahdenne, Kari K Eklund and Kristiina Aalto
    Citation: Pediatric Rheumatology 2023 21:94
  15. Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome is the most common periodic fever syndrome in children; by definition, episodes occur every 2 to 8 weeks. However, in a ...

    Authors: Mor Broide, Yoel Levinsky, Rotem Tal, Liora Harel, Shoval Shoham, Sabreen Abu Ahmad, Yonatan Butbul Aviel and Gil Amarilyo
    Citation: Pediatric Rheumatology 2023 21:93
  16. Fibrodysplasia ossificans progressive (FOP) is an ultra-rare genetic disorder that is caused by a mutation in the ACVR1 gene and provokes severe heterotopic ossification. Since flares of the disease are associate...

    Authors: Irina P. Nikishina, Svetlana V. Arsenyeva, Valeria G. Matkava, Alia N. Arefieva, Mariya I. Kaleda, Alexandr V. Smirnov, Leonid M. Blank and Mikhail M. Kostik
    Citation: Pediatric Rheumatology 2023 21:92
  17. The aim of this study was to compare pain-scores in three targeted treatment-strategies in JIA-patients and to identify characteristics predicting persistent pain.

    Authors: Katinka Spekking, Janneke Anink, Piroska de Boer, Sytske Anne Bergstra, J. Merlijn van den Berg, Dieneke Schonenberg-Meinema, Lisette W. A. van Suijlekom-Smit, Marion A. J. van Rossum, Yvonne Koopman-Keemink, Rebecca ten Cate, Cornelia F. Allaart, Daniëlle M. C. Brinkman and Petra C. E. Hissink Muller
    Citation: Pediatric Rheumatology 2023 21:90
  18. Granulomatosis with polyangiitis (GPA) is an autoimmune disease characterized by chronic vasculitis involving small to medium sized arteries, granulomatous inflammation of the upper and lower respiratory tract...

    Authors: Esraa Eloseily and Michael Henrickson
    Citation: Pediatric Rheumatology 2023 21:89
  19. Kikuchi-Fujimoto disease (KFD) is typically a benign, self-limiting inflammatory disease. The diagnosis of KFD can be challenging for nonspecific symptoms, laboratory or imaging findings. In this study, we aim...

    Authors: Tingyan He, Zixuan Shen, Jiayun Ling, Xiaona Zhu and Jun Yang
    Citation: Pediatric Rheumatology 2023 21:88
  20. IgA vasculitis (IgAV) is a small vessel vasculitis that is more common in childhood. Very limited evidence exists on patients who experience an atypical disease course. The aim of this study was to describe a ...

    Authors: Julien Marro, Chloe Williams, Clare E. Pain and Louise Oni
    Citation: Pediatric Rheumatology 2023 21:85
  21. Childhood Sjögren’s Disease (cSjD) is an underdiagnosed phenomenon with clinical and pathophysiological nuances in contrast to Sjögren’s Disease (SjD) in the adult population. While adults typically experience...

    Authors: Kristin Drew, René Kronlage, Seunghee Cha, Akaluck Thatayatikom and Thomas Schrepfer
    Citation: Pediatric Rheumatology 2023 21:83
  22. Growing evidence suggests that infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may trigger idiopathic inflammatory myopathies (IIM). Few studies have described individual juvenile I...

    Authors: Jessica Perfetto, Donna A. Yoo, Carolina Y. Tamashiro, Megan M. Perron, Natalia Vasquez-Canizares and Dawn M. Wahezi
    Citation: Pediatric Rheumatology 2023 21:82
  23. Currently, monoarticular Juvenile Idiopathic Arthritis (monoJIA) is included in the ILAR classification as oligoarticular subtype although various aspects, from clinical practice, suggest it as a separate entity.

    Authors: Francesco Zulian, Beatrice Pierobon, Maria Elisabetta Zannin, Caterina Politi, Fabio Vittadello, Alessandra Meneghel, Francesca Tirelli and Giorgia Martini
    Citation: Pediatric Rheumatology 2023 21:81
  24. To review whether the current COVID-19 vaccines can prevent the occurrence of multisystem inflammatory syndrome in children (MIS-C) and adolescents.

    Authors: Mohamad Hamad Saied, Laura van der Griend, Joeri W van Straalen, Nico M. Wulffraat, Sebastiaan Vastert and Marc H A Jansen
    Citation: Pediatric Rheumatology 2023 21:80
  25. Kawasaki disease (KD) is an acute pediatric vasculitis affecting genetically susceptible infants and children. Although the pathogenesis of KD remains unclear, growing evidence links genetic susceptibility to ...

    Authors: Xing Zhang, Ying Sun, Lijuan Meng, Caixia Ye, Huifeng Han, Tiesong Zhang, Yue Feng, Jianxiao Li, Lifen Duan and Yanfei Chen
    Citation: Pediatric Rheumatology 2023 21:78
  26. C1-C2 subluxation is a rare complication of enthesitis-related arthritis (ERA). If left untreated, it may lead to functional impairment or cervical spinal cord compression. This study aims to highlight key poi...

    Authors: Wing Hin Stanford Siu, Chao-Jan Wang, Chieh-Tsai Wu, Chao-Yi Wu and Liang-Shiou Ou
    Citation: Pediatric Rheumatology 2023 21:77
  27. Evidence for the treatment of multisystem inflammatory syndrome in children (MIS-C) is lacking. Anakinra, which targets IL-1-mediated inflammation, is reserved for refractory cases of MIS-C; however, its use i...

    Authors: Brian L.P. Dizon, Christopher Redmond, Emily C. Gotschlich, Sangeeta Sule, Tova Ronis, Kathleen M. Vazzana, Matthew A. Sherman, Rachael Connor, Abigail Bosk, Niti Dham, Ashraf S. Harahsheh, Elizabeth Wells, Roberta DeBiasi and Hemalatha Srinivasalu
    Citation: Pediatric Rheumatology 2023 21:76
  28. Juvenile idiopathic arthritis (JIA) is a common pediatric rheumatic condition and is associated with symptoms such as joint pain that can negatively impact health-related quality of life. To effectively manage...

    Authors: Karine Toupin-April, Isabelle Gaboury, Laurie Proulx, Adam M. Huber, Ciarán M. Duffy, Esi M. Morgan, Linda C. Li, Elizabeth Stringer, Mark Connelly, Jennifer E. Weiss, Michele Gibbon, Hannah Sachs, Aditi Sivakumar, Alexandra Sirois, Emily Sirotich, Natasha Trehan…
    Citation: Pediatric Rheumatology 2023 21:74
  29. Immunization with meningococcal ACWY conjugate vaccine induces protective antibodies against invasive meningococcal disease (IMD) caused by serogroups A, C, W and Y. We studied MenACWY-TT vaccine immunogenicit...

    Authors: Milou Ohm, Joeri W van Straalen, Gerrie de Joode-Smink, Joris van Montfrans, Marije Bartels, Joanne G van Wildenbeest, Caroline A Lindemans, Roos AW Wennink, Joke H de Boer, Elisabeth AM Sanders, Frans M Verduyn-Lunel, Guy AM Berbers, Nico M Wulffraat and Marc H.A. Jansen
    Citation: Pediatric Rheumatology 2023 21:73
  30. Rheumatoid factor (RF)-positive polyarthritis is the least common type of juvenile idiopathic arthritis (JIA). Functional disability in RF-positive polyarthritis patients is much more severe than in patients w...

    Authors: Semanur Ozdel, Hafize Emine Sönmez, Şengül Çağlayan, Özlem Akgün, Tuncay Aydın, Özge Baba, İlknur Bağrul, Gülçin Otar Yener, Kübra Öztürk, Ferhat Demir, Deniz Gezgin Yıldırım, Şerife Gül Karadağ, Esra Bağlan, Mustafa Çakan, Mukaddes Kalyoncu, Balahan Bora Makay…
    Citation: Pediatric Rheumatology 2023 21:72
  31. Primary immunodeficiencies are immunological disorders caused by gene mutations involved in immune system development and activation. Recently, activated phosphoinositide 3-kinase delta syndrome (APDS) due to ...

    Authors: Niloofar Shashaani, Zahra Chavoshzadeh, Leila Ghasemi, Shabnam Hajiani Ghotbabadi, Sara Shiari, Samin Sharafian and Reza Shiari
    Citation: Pediatric Rheumatology 2023 21:71
  32. CLUSTER is a UK consortium focussed on precision medicine research in JIA/JIA-Uveitis. As part of this programme, a large-scale JIA data resource was created by harmonizing and pooling existing real-world stud...

    Authors: Saskia Lawson-Tovey, Samantha Louise Smith, Nophar Geifman, Stephanie Shoop-Worrall, Sandra Ng, Michael R. Barnes, Lucy R. Wedderburn and Kimme L. Hyrich
    Citation: Pediatric Rheumatology 2023 21:70
  33. Approximately one third of children with JIA receive biologic therapy, but evidence on biologic therapy withdrawal is lacking. This study aims to increase our understanding of whether and when pediatric rheuma...

    Authors: Janine A. van Til, Michelle M. A. Kip, Ellen J. H. Schatorjé, Gillian Currie, Marinka Twilt, Susanne M. Benseler, Joost F. Swart, Sebastiaan J. Vastert, Nico Wulffraat, Rae S. M. Yeung, C. G. M. (Karin) Groothuis-Oudshoorn, Sanne Warta, Deborah A. Marshall and Maarten J. IJzerman
    Citation: Pediatric Rheumatology 2023 21:69
  34. Children and adolescents with juvenile idiopathic arthritis (JIA) may suffer from disability and disease-related damage. This study aimed to investigate the prevalence of disability and damage, and identify th...

    Authors: Sirikarn Tangcheewinsirikul, Maynart Sukharomana and Sirirat Charuvanij
    Citation: Pediatric Rheumatology 2023 21:68
  35. Resilience has been shown to be associated with better psychological outcomes and ability to cope with negative and traumatic events in the healthcare setting. Therefore, in this study, we aimed to evaluate re...

    Authors: Rebecca Trachtman, Julie Samuels, Emma Wojtal and Brian M Feldman
    Citation: Pediatric Rheumatology 2023 21:67
  36. Chronic nonbacterial osteomyelitis (CNO) is an autoinflammatory bone disorder that predominantly affects children and young people. The pathophysiology and molecular mechanisms of CNO remain poorly understood,...

    Authors: M. Mohanna, E. Roberts, L. Whitty, J. F. Gritzfeld, C. E. Pain, H. J. Girschick, J. Preston, M. Hadjittofi, C. Anderson, P. J. Ferguson, A. Theos and C. M. Hedrich
    Citation: Pediatric Rheumatology 2023 21:65
  37. This is a comprehensive characteristic study of Kawasaki disease (KD) and Multi system inflammatory syndrome in children (MIS-C) in the Middle East that creates a formula to differentiate between the two.

    Authors: Lemis Yavuz, Sarmad AlHamdani, Samah Alasrawi, Deena Wafadari, Ali Al-Fraihat, Marwa A. Bebars, Jaidev Nath, Diego Arango, Marco Pallavidino, Ruchi Jain, Sinan Yavuz, Mohamed AlAwadhi, Abdulla Alkhayat, Ahmad Abou Tayoun and Walid Mohammad Abuhammour
    Citation: Pediatric Rheumatology 2023 21:64
  38. Juvenile Dermatomyositis (JDM) is a rare, chronic, and life-threatening childhood autoimmune disease. Currently, there are recommended, reliable and validated measurement tools for assessment of skin disease a...

    Authors: Alexander Gebreamlak, Katherine M. Sawicka, Rose Garrett, Y. Ingrid Goh, Kayla M. Baker and Brian M. Feldman
    Citation: Pediatric Rheumatology 2023 21:63
  39. Childhood-onset Systemic Lupus Erythematosus (cSLE) is an autoimmune disease associated with fatigue, mood symptoms, and pain. Fortunately, these symptoms are potentially modifiable with psychological interven...

    Authors: Natoshia R. Cunningham, Alaina Miller, Samantha L. Ely, Mallet R. Reid, Ashley Danguecan, Sarah I. Mossad, Luana Flores Pereira, Khalid Abulaban, Elizabeth Kessler, Natalie Rosenwasser, Kabita Nanda, Tamar Rubinstein, Mathew Reeves, Sara Ahola Kohut, Jennifer Stinson, Tala El Tal…
    Citation: Pediatric Rheumatology 2023 21:61
  40. Joint acoustic emissions from knees have been evaluated as a convenient, non-invasive digital biomarker of inflammatory knee involvement in a small cohort of children with Juvenile Idiopathic Arthritis (JIA). ...

    Authors: Quentin Goossens, Miguel Locsin, Sevda Gharehbaghi, Priya Brito, Emily Moise, Lori A Ponder, Omer T Inan and Sampath Prahalad
    Citation: Pediatric Rheumatology 2023 21:59
  41. Children with juvenile idiopathic arthritis (JIA) are at higher risk of decreased bone mineral density (BMD) compared with healthy children due to genetic, disease and medication-related causes. This study aim...

    Authors: Riham Eid, Maha Abdelsalam, Aya Ahmed Fathy, Hadil M. Abolenein, Eman Bakr Elmarghany, Aya Ahmed El-Hanafy, Nashwa Hamdy, Dina Salama Abd-Elmagid, Nermeen A. Niazy and Dina M. Abd-El Ghaffar
    Citation: Pediatric Rheumatology 2023 21:58
  42. Pain is one of the most frequently reported experiences amongst children with Juvenile Idiopathic Arthritis (JIA); however, the management of JIA pain remains challenging. As pain is a multidimensional experi...

    Authors: Yvonne N. Brandelli, Christine T. Chambers, Sean P. Mackinnon, Jennifer A. Parker, Adam M. Huber, Jennifer N. Stinson, Emily M. Wildeboer, Jennifer P. Wilson and Olivia Piccolo
    Citation: Pediatric Rheumatology 2023 21:57
  43. Pediatric uveitis is typically asymptomatic and may become chronic affecting ocular structures and vision. We evaluated visual outcomes, clinical features, medication, and uveitis activity in children with eit...

    Authors: Mira Siiskonen, Iida Hirn, Roosa Pesälä, Pasi Ohtonen and Nina Hautala
    Citation: Pediatric Rheumatology 2023 21:56

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