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  1. Content type: Research article

    In children with Henoch-Schonlein purpura nephritis (HSPN), the degree of proteinuria has been proven to be not only a sign of kidney damage, but also an accelerator of kidney disease progression. Nephrotic pr...

    Authors: Dan Feng, Wen-Yan Huang, Sheng Hao, Xiao-Ling Niu, Ping Wang, Ying Wu and Guang-Hua Zhu

    Citation: Pediatric Rheumatology 2017 15:15

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  2. Content type: Research article

    Systemic Lupus Erythematosus (SLE) is a serious multisystem autoimmune disease, which is more aggressive in children and people of African descent. In South Africa, pediatric SLE (pSLE) patients are at high ri...

    Authors: Laura B. Lewandowski, Melissa H. Watt, Laura E. Schanberg, Nathan M. Thielman and Christiaan Scott

    Citation: Pediatric Rheumatology 2017 15:14

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  3. Content type: Research article

    To study the impact of psoriasis and features associated with psoriasis on classification and outcome in a population-based follow-up cohort of children with juvenile idiopathic arthritis (JIA).

    Authors: Maria Ekelund, Kristiina Aalto, Anders Fasth, Troels Herlin, Susan Nielsen, Ellen Nordal, Suvi Peltoniemi, Marite Rygg, Marek Zak and Lillemor Berntson

    Citation: Pediatric Rheumatology 2017 15:13

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  4. Content type: Research article

    The aim of the study was to determine whether polymorphisms in toll-like receptor 4 (TLR4) confer susceptibility to rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) in a central south Chinese Han...

    Authors: Yan Wang, Lianghui Chen, Fang Li, Meihua Bao, Jie Zeng, Ju Xiang, Huaiqing Luo, Jianming Li and Liang Tang

    Citation: Pediatric Rheumatology 2017 15:12

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  5. Content type: Short report

    Combination therapy with prednisone or etanercept may induce earlier and/or more improvement in disease activity in Disease Modifying Anti Rheumatic Drug (DMARD) naïve non-systemic Juvenile Idiopathic Arthriti...

    Authors: P. C. E. Hissink Muller, D. M. C. Brinkman, D. Schonenberg, Y. Koopman-Keemink, I. C. J. Brederije, W. P. Bekkering, T. W. Kuijpers, M. A. J. van Rossum, L. W. A. van Suijlekom-Smit, J. M. van den Berg, C. F. Allaart and R. ten Cate

    Citation: Pediatric Rheumatology 2017 15:11

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  6. Content type: Research article

    Rheumatic heart disease (RHD) is an autoimmune disease where cross reactive CD4+ T cells are involved in the pathogenesis of valvular damage. Human Leukocyte Antigen-G (HLA-G), an immunosuppressive molecule playi...

    Authors: Maheshkumar Poomarimuthu, Sivakumar Elango, Sambath Soundrapandian and Jayalakshmi Mariakuttikan

    Citation: Pediatric Rheumatology 2017 15:10

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  7. Content type: Research article

    Paediatric rheumatology service in Sub-Sahara African is virtually not available as there is a shortage of paediatric rheumatologists and other rheumatology health professionals. We aim to describe the clinica...

    Authors: Babatunde Hakeem Olaosebikan, Olufemi Oladipo Adelowo, Barakat Adeola Animashaun and Richard Oluyinka Akintayo

    Citation: Pediatric Rheumatology 2017 15:7

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  8. Content type: Research article

    The usefulness of musculoskeletal ultrasonography (MSUS) in paediatric population is limited by lack of reference values. One of such parameters is hip joint capsule thickness, postulated as an early measure f...

    Authors: Zbigniew Żuber, Aleksander Owczarek, Małgorzata Sobczyk, Agata Migas-Majoch, Dorota Turowska-Heydel, Agnieszka Sternal, Justyna Michalczak and Jerzy Chudek

    Citation: Pediatric Rheumatology 2017 15:8

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  9. Content type: Research article

    Pediatric rheumatic diseases are chronic illnesses that can cause considerable disease burden to children and their families. There is limited epidemiologic data on these diseases in East Africa. The aim of th...

    Authors: Angela Migowa, Inés Colmegna, Carol Hitchon, Eugene Were, Evelyn Ng’ang’a, Thomas Ngwiri, John Wachira, Sasha Bernatsky and Rosie Scuccimarri

    Citation: Pediatric Rheumatology 2017 15:4

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  10. Content type: Short report

    Oligoarticular juvenile idiopathic arthritis (oligoJIA), the most common chronic inflammatory arthritis of childhood, usually involves the knees and ankles. Severe oligoJIA monoarthritis presenting in a joint ...

    Authors: Natasha Lepore, Megan Cashin, Debra Bartley and Daniela Simona Ardelean

    Citation: Pediatric Rheumatology 2017 15:2

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  11. Content type: Research article

    Juvenile dermatomyositis (JDM) is the most common form of the idiopathic inflammatory myopathies in children. A subset of children have the rash of JDM without significant weakness, and the optimal treatments ...

    Authors: Susan Kim, Philip Kahn, Angela B. Robinson, Bianca Lang, Andrew Shulman, Edward. J. Oberle, Kenneth Schikler, Megan Lea Curran, Lilliana Barillas-Arias, Charles H. Spencer, Lisa G. Rider and Adam M. Huber

    Citation: Pediatric Rheumatology 2017 15:1

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  12. Content type: Research article

    Data from routine clinical practice are needed to further define the efficacy and safety of biologic medications in children with juvenile idiopathic arthritis (JIA). The aim of this analysis was to investigat...

    Authors: Sara Verazza, Sergio Davì, Alessandro Consolaro, Francesca Bovis, Antonella Insalaco, Silvia Magni-Manzoni, Rebecca Nicolai, Denise Pires Marafon, Fabrizio De Benedetti, Valeria Gerloni, Irene Pontikaki, Francesca Rovelli, Rolando Cimaz, Achille Marino, Francesco Zulian, Giorgia Martini…

    Citation: Pediatric Rheumatology 2016 14:68

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  13. Content type: Research article

    The number of trained specialists world-wide is insufficient to serve all children with pediatric rheumatologic disorders, even in the countries with robust medical resources. We evaluated the potential of dia...

    Authors: Michael M. Segal, Balu Athreya, Mary Beth F. Son, Irit Tirosh, Jonathan S. Hausmann, Elizabeth Y. N. Ang, David Zurakowski, Lynn K. Feldman and Robert P. Sundel

    Citation: Pediatric Rheumatology 2016 14:67

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  14. Content type: Research article

    Fatigue is common in patients with JIA and affects daily life negatively. We assessed the presence and severity of fatigue in patients with JIA, including factors presumed associated with fatigue (e.g., diseas...

    Authors: Wineke Armbrust, Otto H. T. M. Lelieveld, Jolanda Tuinstra, Nico M. Wulffraat, G. J. F. Joyce Bos, Jeannette Cappon, Marion A. J. van Rossum, Pieter J. J. Sauer and Mariët Hagedoorn

    Citation: Pediatric Rheumatology 2016 14:65

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  15. Content type: Research article

    Dystrophic calcifications may occur in patients with J uvenile Idiopathic Inflammatory Myopathy (JIIM) as well as other connective tissue and metabolic diseases, but a reliable method of measuring the volume o...

    Authors: Maria Ibarra, Cynthia Rigsby, Gabrielle A. Morgan, Christina L. Sammet, Chiang-Ching Huang, Dong Xu, Ira N. Targoff and Lauren M. Pachman

    Citation: Pediatric Rheumatology 2016 14:64

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  16. Content type: Research article

    Juvenile idiopathic arthritis (JIA) is a systemic chronic inflammatory disease. Studies using tissue Doppler imaging (TDI) for the evaluation of cardiac functions of children with JIA are limited. Thus, this s...

    Authors: Azza Z. El Eraky, Nesrin M. Handoka, Mona Sayed Ghaly, Samah Ismail Nasef, Nahed A. Eldahshan, Ahmed M. Ibrahim and Sherein Shalaby

    Citation: Pediatric Rheumatology 2016 14:62

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  17. Content type: Case Report

    The pathophysiological origin of juvenile idiopathic arthritis (JIA) is largely unknown. However, individuals with presumably pathogenic mutations in FAMIN have been reported, associating this gene with a rare su...

    Authors: Tilmann Kallinich, Anne Thorwarth, Sae-Lim von Stuckrad, Angela Rösen-Wolff, Hella Luksch, Patrick Hundsdoerfer, Kirsten Minden and Peter Krawitz

    Citation: Pediatric Rheumatology 2016 14:63

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  18. Content type: Research article

    The purpose of the study is to determine levels of total cholesterol (TC), low-density, and high-density lipoprotein fractions of cholesterol (LDLc and HDLc), in patients with juvenile idiopathic arthritis (JI...

    Authors: Anna-Helene Bohr, Freddy Karup Pedersen, Claus Henrik Nielsen and Klaus Gottlob Müller

    Citation: Pediatric Rheumatology 2016 14:61

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  19. Content type: Research article

    Juvenile dermatomyositis (JDM) is a rare idiopathic inflammatory childhood myopathy of uncertain aetiology. The demographic and clinical presentation of JDM may differ by race and geographic regions. Few studi...

    Authors: Lawrence Owino Okong’o, Monika Esser, Jo Wilmshurst and Christiaan Scott

    Citation: Pediatric Rheumatology 2016 14:60

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  20. Content type: Research article

    Rheumatic diseases are associated with an increased fracture risk. The tissue level characteristics of the bone involvement in children have not been well elucidated. Our objectives were to describe the bone m...

    Authors: Jennifer Harrington, Douglas Holmyard, Earl Silverman, Etienne Sochett and Marc Grynpas

    Citation: Pediatric Rheumatology 2016 14:58

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  21. Content type: Case Report

    Sarcoidosis is a multi-system disease characterized by the presence of non-caseating epithelioid granulomas in affected tissues, including skeletal muscle. These organized collections of immune cells have impo...

    Authors: Amir B. Orandi, Eric Eutsler, Cole Ferguson, Andrew J. White and Maleewan Kitcharoensakkul

    Citation: Pediatric Rheumatology 2016 14:59

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  22. Content type: Research article

    Taking medicines as intended is difficult for everybody, but young people going through adolescence have greater problems than adults and younger children. One of the most important things that happen during t...

    Authors: J. E. McDonagh, K. L. Shaw, J. Prescott, F. J. Smith, R. Roberts and N. J. Gray

    Citation: Pediatric Rheumatology 2016 14:57

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  23. Content type: Short Report

    Arterial vessel wall dissection is a rare, life-threatening and rarely described complication in childhood Takayasu Arteritis (cTA). Prevalence and risk factors for arterial dissection in cTA are unknown. We s...

    Authors: Florence A. Aeschlimann, Lars Grosse-Wortmann, Susanne M. Benseler, Ronald M. Laxer, Diane Hebert and Rae S.M. Yeung

    Citation: Pediatric Rheumatology 2016 14:56

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  24. Content type: Review

    Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in childhood. The pathogenesis of JIA is thought to be the result of a combination of host genetic and environmental triggers. However, ...

    Authors: Anouk Verwoerd, Nienke M. Ter Haar, Sytze de Roock, Sebastiaan J. Vastert and Debby Bogaert

    Citation: Pediatric Rheumatology 2016 14:55

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  25. Content type: Research article

    There is a critical shortage of pediatric rheumatologists in the US. Substantial travel to clinics can impose time and monetary burdens on families. The aim of this study was to evaluate the cost of in-person ...

    Authors: Elizabeth A. Kessler, Ashley K. Sherman and Mara L. Becker

    Citation: Pediatric Rheumatology 2016 14:54

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  26. Content type: Research article

    Parents struggle when making treatment decisions for children with arthritis or other chronic conditions. Understanding their decision-making process is an essential step towards improving the decision-making ...

    Authors: Ellen A. Lipstein, Daniel J. Lovell, Lee A. Denson, Sandra C. Kim, Charles Spencer and Maria T. Britto

    Citation: Pediatric Rheumatology 2016 14:53

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  27. Content type: Case Report

    High-dose intravenous immune globulins (IVIg) are frequently used in refractory juvenile dermatomyositis (JDM) but are often poorly tolerated. High-dose recombinant human hyaluronidase-facilitated subcutaneous...

    Authors: Fabian Speth, Johannes-Peter Haas and Claas H. Hinze

    Citation: Pediatric Rheumatology 2016 14:52

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  28. Content type: Review

    The deficiency of Adenosine Deaminase 2 (DADA2) is a new autoinflammatory disease characterised by an early onset vasculopathy with livedoid skin rash associated with systemic manifestations, CNS involvement a...

    Authors: Roberta Caorsi, Federica Penco, Francesca Schena and Marco Gattorno

    Citation: Pediatric Rheumatology 2016 14:51

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  29. Content type: Research article

    To investigate the utilization of health care services before and after transfer from pediatric to adult rheumatology care in clinical practice.

    Authors: Melissa L. Mannion, Fenglong Xie, John Baddley, Lang Chen, Jeffrey R. Curtis, Kenneth Saag, Jie Zhang and Timothy Beukelman

    Citation: Pediatric Rheumatology 2016 14:49

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  30. Content type: Research article

    Adolescents with Juvenile Idiopathic Arthritis (JIA) are at risk for physical, emotional, social and role challenges that negatively impact quality of life. Peer mentoring has been shown to improve positive he...

    Authors: Jennifer Stinson, Sara Ahola Kohut, Paula Forgeron, Khush Amaria, Mary Bell, Miriam Kaufman, Nadia Luca, Stephanie Luca, Lauren Harris, Charles Victor and Lynn Spiegel

    Citation: Pediatric Rheumatology 2016 14:48

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  31. Content type: Research article

    Fibromyalgia (FM) is a common pain condition characterized by widespread musculoskeletal pain and tenderness. Pregabalin is an approved treatment for adults in the United States, but there are no approved trea...

    Authors: Lesley M. Arnold, Kenneth N. Schikler, Lucinda Bateman, Tahira Khan, Lynne Pauer, Pritha Bhadra-Brown, Andrew Clair, Marci L. Chew and Joseph Scavone

    Citation: Pediatric Rheumatology 2016 14:46

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  32. Content type: Research article

    Adherence to treatment in children with juvenile idiopathic arthritis (JIA) is associated with better outcomes. Assessing patient adherence in JIA, as well as attitudes and beliefs about prescribed treatments,...

    Authors: Karine Toupin April, Johanne Higgins and Debbie Ehrmann Feldman

    Citation: Pediatric Rheumatology 2016 14:45

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  33. Content type: Research article

    Adolescents with juvenile fibromyalgia (JFM) tend to be very sedentary and avoid participation in physical activity. A prior study suggested that JFM patients show altered biomechanics compared to healthy adol...

    Authors: Susan T. Tran, Staci Thomas, Christopher DiCesare, Megan Pfeiffer, Soumitri Sil, Tracy V. Ting, Sara E. Williams, Gregory D. Myer and Susmita Kashikar-Zuck

    Citation: Pediatric Rheumatology 2016 14:43

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  34. Content type: Meeting abstracts

    P1 Serologic evidence of gut-driven systemic inflammation in juvenile idiopathic arthritis

    Authors: Lampros Fotis, Nur Shaikh, Kevin Baszis, Anthony French, Phillip Tarr, Sriharsha Grevich, Peggy Lee, Sarah Ringold, Brian Leroux, Hannah Leahey, Megan Yuasa, Jessica Foster, Jeremy Sokolove, Lauren Lahey, William Robinson, Joshua Newsom…

    Citation: Pediatric Rheumatology 2016 14(Suppl 1):41

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    This article is part of a Supplement: Volume 14 Supplement 1

  35. Content type: Research article

    To compare physical activity (PA) in children with juvenile idiopathic arthritis (JIA) with controls and to analyse the effect of disease specific factors on PA in children with JIA treated according to curren...

    Authors: G. J. F. Joyce Bos, Otto T. H. M. Lelieveld, Wineke Armbrust, Pieter J. J. Sauer, Jan H. B. Geertzen and Pieter U. Dijkstra

    Citation: Pediatric Rheumatology 2016 14:42

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  36. Content type: Review

    Juvenile idiopathic arthritis (JIA) is a clinically diverse and genetically complex autoimmune disease. Currently, there is very limited understanding of the potential underlying mechanisms that result in the ...

    Authors: Rachelle Donn, Chiara De Leonibus, Stefan Meyer and Adam Stevens

    Citation: Pediatric Rheumatology 2016 14:40

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  37. Content type: Research article

    The Mediterranean fever (MEFV) gene codes for protein pyrin, one of the regulators of inflammasome activity in innate immune cells. Mutations in this gene are considered the primary cause of Familial Mediterranea...

    Authors: Jelena Milenković, Jelena Vojinović, Maruša Debeljak, Nataša Toplak, Dragana Lazarević, Tadej Avčin, Tatjana Jevtović-Stoimenov, Dušica Pavlović, Vladmila Bojanić, Maja Milojković, Gordana Kocić and Andrej Veljković

    Citation: Pediatric Rheumatology 2016 14:39

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  38. Content type: Review

    The syndrome of periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA syndrome) is the most common cause of periodic fever in childhood. The current pharmacological treatment includes c...

    Authors: Federica Vanoni, Katerina Theodoropoulou and Michaël Hofer

    Citation: Pediatric Rheumatology 2016 14:38

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  39. Content type: Case Report

    A small percentage of children with Henoch-Schönlein purpura (HSP) develop a chronic form of the disease that often requires prolonged corticosteroid therapy. Disease modifying anti-rheumatic agents (DMARDs) o...

    Authors: Lampros Fotis, Paul V. Tuttle IV, Kevin W. Baszis, Peri H. Pepmueller, Terry L. Moore and Andrew J. White

    Citation: Pediatric Rheumatology 2016 14:37

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  40. Content type: Research article

    There is a lack of published evidence on the importance of methotrexate (MTX) dose and route of administration on both its efficacy and adverse events in children with Juvenile Idiopathic Arthritis (JIA). We a...

    Authors: J. Fráňová, Š. Fingerhutová, K. Kobrová, R. Srp, D. Němcová, J. Hoza, M. Uher, M. Saifridová, L. Linková and P. Doležalová

    Citation: Pediatric Rheumatology 2016 14:36

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  41. Content type: Review

    Defective regulation of type I interferon response is associated with severe inflammatory phenotypes and autoimmunity. Type I interferonopathies are a clinically heterogenic group of Mendelian diseases with a ...

    Authors: Stefano Volpi, Paolo Picco, Roberta Caorsi, Fabio Candotti and Marco Gattorno

    Citation: Pediatric Rheumatology 2016 14:35

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  42. Content type: Research article

    To analyze the clinical presentation and complications of varicella zoster virus (VZV) infection in children with rheumatic diseases treated with immunosuppressive medication such as biological disease-modifyi...

    Authors: Raphael Leuvenink, Florence Aeschlimann, Walter Baer, Gerald Berthet, Elvira Cannizzaro, Michael Hofer, Daniela Kaiser, Silke Schroeder, Ulrich Heininger and Andreas Woerner

    Citation: Pediatric Rheumatology 2016 14:34

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