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  1. Connective tissue nevi (CTN) are congenital hamartomas caused by excessive proliferation of dermis components. In children, CTN can mimic juvenile localized scleroderma (JLS), an immune mediated skin disorder ...

    Authors: F. Tirelli, C. Giraudo, M. Soliani, F. Calabrese, G. Martini, P. Gisondi, A. Meneghel and Francesco Zulian
    Citation: Pediatric Rheumatology 2023 21:125
    Content type: Research article Published on:

  2. Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that is associated with multiple organ involvement and leads to significant morbidity and mortality. One of the important environmental facto...

    Authors: Porntipa Suebsarakam and Dara Mairiang
    Citation: Pediatric Rheumatology 2023 21:123
    Content type: Research article Published on:

  3. Hypermobile Ehlers-Danlos syndrome (hEDS) is characterized by joint and skin laxity, and often accompanied by chronic pain, dysautonomia, increased distress and, functional limitations. The journey to accurate...

    Authors: Estée C.H. Feldman, Kendra J. Homan, Sara E. Williams, Tracy V. Ting, Kenneth R. Goldschneider and Susmita Kashikar-Zuck
    Citation: Pediatric Rheumatology 2023 21:121
    Content type: Review Published on:

  4. Pediatric rheumatology faces a looming supply-demand crisis. While strategies have been proposed to address the supply shortfall, investigation into the increased demand for pediatric rheumatic care has been l...

    Authors: Daniel D Reiff, John M Bridges, Eileen C Rife, Victoria L Gennaro, Linda McAllister, Annelle Reed, Carolyn Smith, Bethany Walker, Peter Weiser, Emily A Smitherman, Matthew L Stoll, Melissa L Mannion and Randy Q Cron
    Citation: Pediatric Rheumatology 2023 21:120
    Content type: Research article Published on:

  5. Sjögren’s syndrome (SS) is a rare disease with unclear diagnostic criteria among the children and adolescents. The purpose of this study is to describe the clinical features of pediatric Sjögren’s syndrome and...

    Authors: Ling Hou, Ningning Wang, Chengguang Zhao, Xiuli Wang and Yue Du
    Citation: Pediatric Rheumatology 2023 21:119
    Content type: Research article Published on:

  6. We lack a reliable indicator of disease activity in Juvenile Dermatomyositis (JDM), a rare disease. The goal of this study is to identify the association of nailfold capillary End Row Loop (ERL) loss with dise...

    Authors: Lauren M. Pachman, Gabrielle Morgan, Marisa S. Klein-Gitelman, Najah Ahsan and Amer Khojah
    Citation: Pediatric Rheumatology 2023 21:118
    Content type: Short Report Published on:

  7. Aicardi-Goutières syndrome (AGS) is a rare hereditary early-onset encephalopathy characterized by upregulation of the type I interferon pathway, poorly responsive to conventional immunosuppression.

    Authors: Wei Wang, Wei Wang, Siming Peng, Sihao Gao, Meiying Quan, Lijuan Gou, Changyan Wang, Zhixing Sun, Zhuo Li, Dongmei Lian and Hongmei Song
    Citation: Pediatric Rheumatology 2023 21:117
    Content type: Case Report Published on:

  8. Physiotherapy appears as a promising therapy option for patients with Juvenile Idiopathic Arthritis (JIA) [1, 2], but the effects of physiotherapy and jaw exercises on JIA-related orofacial symptoms remain unknow...

    Authors: Stratos Vassis, Cory M. Resnick, Mette Nørgaard, Kathleen M. Strawn, Helle Grove, Beatrice Noeldeke, Troels Herlin, Thomas Klit Pedersen and Peter Bangsgaard Stoustrup
    Citation: Pediatric Rheumatology 2023 21:116
    Content type: Research article Published on:

  9. Macrophage activation syndrome (MAS) is a severe, potentially fatal complication of rheumatic diseases, predominantly in systemic juvenile idiopathic arthritis (SJIA), and is considered as an autoinflammatory ...

    Authors: Meiping Lu, Liping Teng, Yiping Xu and Xuefeng Xu
    Citation: Pediatric Rheumatology 2023 21:115
    Content type: Letter to the Editor Published on:

  10. The epidemiology of Juvenile Dermatomyositis (JDM) in non-Caucasian population is poorly described. We performed a study of patients followed up in the French West Indies for JDM. We aimed to describe clinical...

    Authors: Arthur Felix, Frederique Delion, Fabienne Louis-Sidney, Lindsay Osei, Aurélie Armougon, Remi Bellance, Moustapha Dramé, Christophe Deligny, Benoit Suzon and Yves Hatchuel
    Citation: Pediatric Rheumatology 2023 21:113
    Content type: Short Report Published on:

  11. Anakinra is a recombinant interleukin-1 (IL-1) receptor antagonist used in systemic juvenile idiopathic arthritis (sJIA), refractory Kawasaki disease (KD) and cryopyrin-associated autoinflammatory syndrome (CA...

    Authors: Frederico Rajão Martins, André Costa Azevedo, Sara Ganhão, Francisca Aguiar, Mariana Rodrigues and Iva Brito
    Citation: Pediatric Rheumatology 2023 21:112
    Content type: Case Report Published on:

  12. This paper presents insight into the scale of mental health concerns for families who have a child or young person with a diagnosis of Juvenile Idiopathic Arthritis (JIA) living in any of the four nations of t...

    Authors: Polly Livermore, S. Ainsworth, R. Beesley, S. Douglas, E. Earle, D. Wilson, L. Woolley and J. Clinch
    Citation: Pediatric Rheumatology 2023 21:111
    Content type: Research article Published on:

  13. The prevalence of Celiac Disease (CD) in Juvenile Idiopathic Arthritis (JIA) has been reported to be 0.1–7% in various small studies. As a result of the limited number of research and their inconclusive result...

    Authors: Angela Taneja Kohli, Aimee O. Hersh, Lori Ponder, Lai Hin Kimi Chan, Kelly A. Rouster-Stevens, Anne E. Tebo, Subra Kugathasan, Stephen L. Guthery, John F. Bohnsack and Sampath Prahalad
    Citation: Pediatric Rheumatology 2023 21:110
    Content type: Research article Published on:

  14. Pediatric uveitis is a severe inflammatory ocular condition that can lead to sight-threatening complications and can negatively impact quality of life. The retinal microcirculation is often affected in interme...

    Authors: Carlyn V. Kouwenberg, Julia Spierings, Evianne L. de Groot, Joke H. de Boer and Viera Kalinina Ayuso
    Citation: Pediatric Rheumatology 2023 21:109
    Content type: Research article Published on:

  15. The objective of this initiative was to develop a treat-to-target (T2T) approach for the management of patients with Familial Mediterranean Fever (FMF), including the definition of a complex treatment target, ...

    Authors: Lisa Ehlers, Elisabeth Rolfes, Mareike Lieber, Dominik Müller, Elke Lainka, Faekah Gohar, Günter Klaus, Hermann Girschick, Jana Hörstermann, Jasmin Kümmerle-Deschner, Jürgen Brunner, Katharina Palm-Beden, Klaus Tenbrock, Lusine von Wrangel, Maria Faßhauer, Norbert Blank…
    Citation: Pediatric Rheumatology 2023 21:108
    Content type: Research article Published on:

  16. In juvenile idiopathic arthritis (JIA) clinical remission is unattainable in some patients despite modern biologic disease-modifying antirheumatic drugs (bDMARD) therapy and switching bDMARD is required. The b...

    Authors: Mia Lindegaard Pedersen, Amalie Neve-Græsbøll, Troels Herlin and Mia Glerup
    Citation: Pediatric Rheumatology 2023 21:107
    Content type: Research article Published on:

  17. Macrophage activation syndrome (MAS) is a severe and life-threatening syndrome associated with autoimmune diseases. The coexistence of MAS and juvenile dermatomyositis (JDM) is not well reported. This report d...

    Authors: Yong Chang, Xueyan Shan and Yongpeng Ge
    Citation: Pediatric Rheumatology 2023 21:106
    Content type: Review Published on:

  18. Musculoskeletal ultrasound is a well accessible technique to assess disease activity in children with juvenile idiopathic arthritis. Knowledge of reference values of joint structures is indispensable to differ...

    Authors: Ruth Wittoek, Céline Decock, Nele Dewaele, Lara Arnold, Pieter Baeyens, Ignace De Schrijver, Lisa Pardaens, Ioannis Raftakis, Thomas Renson, Charline Rinkin, Alexander D. J. Thooft, Tine Vanhaverbeke and Caroline Verbist
    Citation: Pediatric Rheumatology 2023 21:105
    Content type: Research article Published on:

  19. Juvenile dermatomyositis (jDM) is the most common idiopathic inflammatory myopathy of childhood. Amyopathic or hypomyopathic courses have been described.

    Authors: Timmy Strauss, Claudia Günther, Anja Schnabel, Christine Wolf, Gabriele Hahn, Min Ae Lee-Kirsch and Normi Brück
    Citation: Pediatric Rheumatology 2023 21:104
    Content type: Case Report Published on:

  20. Paediatric rheumatic diseases cause considerable disease burden to children and their families (Moorthy LN, Peterson MGE, Hassett AL, et al, Pediatric Rheumatology 8:20, 2010). Delayed diagnosis is a significa...

    Authors: Jacqueline E. Kawishe, Anthony Ngugi, Stanley Luchters, Helen Foster and Angela Migowa
    Citation: Pediatric Rheumatology 2023 21:103
    Content type: Research article Published on:

  21. To identify baseline predictors of persisting pain in children with Juvenile Idiopathic Arthritis (JIA), relative to patients with JIA who had similar baseline levels of pain but in whom the pain did not persist.

    Authors: Tara McGrath, Jaime Guzman, Lori Tucker, Natalie J. Shiff, Maryna Yaskina, Susan Tupper and Dax G. Rumsey
    Citation: Pediatric Rheumatology 2023 21:102
    Content type: Research article Published on:

  22. Sweet syndrome (SS), also known as acute febrile neutrophilic dermatosis, is an immunologic syndrome characterized by widespread neutrophilic infiltration. Histiocytoid Sweet syndrome (H-SS) is a histopatholog...

    Authors: Margaret Irwin, Veeraya K. Tanawattanacharoen, Amy Turner, Mary Beth F. Son, Rebecca C. Hale, Craig D. Platt, Juan Putra, Birgitta A.R. Schmidt and Mollie G. Wasserman
    Citation: Pediatric Rheumatology 2023 21:101
    Content type: Case Report Published on:

  23. Throughout the COVID-19 pandemic, there have been concerns regarding the risks of infection in patients with autoimmune disease. In this study, we investigated the impact of the pandemic on patients with juven...

    Authors: Dawn M. Wahezi, Dominique Jerome, Evin Rothschild, Belina Yi, Jeffrey Dvergsten, Stacey Tarvin, Susan Kim and Tamar Rubinstein
    Citation: Pediatric Rheumatology 2023 21:100
    Content type: Research article Published on:

  24. Tocilizumab is a humanized monoclonal antibody that acts as an IL-6 receptor antagonist. Intravenous tocilizumab is considered an option for children with anti-TNF refractory juvenile idiopathic arthritis-asso...

    Authors: Francesca Burlo, Cristina Tumminelli, Serena Pastore, Gabriele Stocco, Debora Curci, Marianna Lucafò, Alberto Tommasini and Andrea Taddio
    Citation: Pediatric Rheumatology 2023 21:99
    Content type: Research article Published on:

  27. Systemic juvenile idiopathic arthritis (systemic JIA) is a severe disease with both systemic and joint inflammation. This study aims to identify predictors of disease evolution within the systemic JIA populati...

    Authors: M. Wallimann, K. Bouayed, E. Cannizzaro, D. Kaiser, A. Belot, E. Merlin, S. Poignant, C. Wouters, F. Hofer, T. Saurenmann, A. Koryllou, R. Carlomagno, M. Mejbri, M. Hofer and K. Theodoropoulou
    Citation: Pediatric Rheumatology 2023 21:96
    Content type: Research article Published on:

  28. Although the advent of new therapeutics for juvenile idiopathic arthritis (JIA) patients has considerably lessened the impact of the disease and reduced its sequelae, the outcomes of JIA remain important in th...

    Authors: Carine Savel, Aurélie Chausset, Pauline Berland, Candy Guiguet-Auclair, Laura Cabane, Bruno Fautrel, Philippe Gaudin, Pascale Guillot, Gilles Hayem, Delphine Lafarge, Etienne Merlin, Nadine Pezière, Christelle Sordet, Sonia Trope, Anne Tournadre, Sandrine Malochet…
    Citation: Pediatric Rheumatology 2023 21:95
    Content type: Research article Published on:

  29. The aim of this long-term follow-up study was to compare the disease characteristics of HLA-B27 positive and negative patients with juvenile idiopathic arthritis (JIA).

    Authors: Suvi Oili Orvokki Peltoniemi, Mia Glerup, Pekka Lahdenne, Kari K Eklund and Kristiina Aalto
    Citation: Pediatric Rheumatology 2023 21:94
    Content type: Research article Published on:

  30. Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome is the most common periodic fever syndrome in children; by definition, episodes occur every 2 to 8 weeks. However, in a ...

    Authors: Mor Broide, Yoel Levinsky, Rotem Tal, Liora Harel, Shoval Shoham, Sabreen Abu Ahmad, Yonatan Butbul Aviel and Gil Amarilyo
    Citation: Pediatric Rheumatology 2023 21:93
    Content type: Research article Published on:

  31. Fibrodysplasia ossificans progressive (FOP) is an ultra-rare genetic disorder that is caused by a mutation in the ACVR1 gene and provokes severe heterotopic ossification. Since flares of the disease are associate...

    Authors: Irina P. Nikishina, Svetlana V. Arsenyeva, Valeria G. Matkava, Alia N. Arefieva, Mariya I. Kaleda, Alexandr V. Smirnov, Leonid M. Blank and Mikhail M. Kostik
    Citation: Pediatric Rheumatology 2023 21:92
    Content type: Research article Published on:

  32. The aim of this study was to compare pain-scores in three targeted treatment-strategies in JIA-patients and to identify characteristics predicting persistent pain.

    Authors: Katinka Spekking, Janneke Anink, Piroska de Boer, Sytske Anne Bergstra, J. Merlijn van den Berg, Dieneke Schonenberg-Meinema, Lisette W. A. van Suijlekom-Smit, Marion A. J. van Rossum, Yvonne Koopman-Keemink, Rebecca ten Cate, Cornelia F. Allaart, Daniëlle M. C. Brinkman and Petra C. E. Hissink Muller
    Citation: Pediatric Rheumatology 2023 21:90
    Content type: Research article Published on:

  33. Granulomatosis with polyangiitis (GPA) is an autoimmune disease characterized by chronic vasculitis involving small to medium sized arteries, granulomatous inflammation of the upper and lower respiratory tract...

    Authors: Esraa Eloseily and Michael Henrickson
    Citation: Pediatric Rheumatology 2023 21:89
    Content type: Case Report Published on:

  34. Kikuchi-Fujimoto disease (KFD) is typically a benign, self-limiting inflammatory disease. The diagnosis of KFD can be challenging for nonspecific symptoms, laboratory or imaging findings. In this study, we aim...

    Authors: Tingyan He, Zixuan Shen, Jiayun Ling, Xiaona Zhu and Jun Yang
    Citation: Pediatric Rheumatology 2023 21:88
    Content type: Research article Published on:

  35. IgA vasculitis (IgAV) is a small vessel vasculitis that is more common in childhood. Very limited evidence exists on patients who experience an atypical disease course. The aim of this study was to describe a ...

    Authors: Julien Marro, Chloe Williams, Clare E. Pain and Louise Oni
    Citation: Pediatric Rheumatology 2023 21:85
    Content type: Research article Published on:

  37. Childhood Sjögren’s Disease (cSjD) is an underdiagnosed phenomenon with clinical and pathophysiological nuances in contrast to Sjögren’s Disease (SjD) in the adult population. While adults typically experience...

    Authors: Kristin Drew, René Kronlage, Seunghee Cha, Akaluck Thatayatikom and Thomas Schrepfer
    Citation: Pediatric Rheumatology 2023 21:83
    Content type: Case Report Published on:

  38. Growing evidence suggests that infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may trigger idiopathic inflammatory myopathies (IIM). Few studies have described individual juvenile I...

    Authors: Jessica Perfetto, Donna A. Yoo, Carolina Y. Tamashiro, Megan M. Perron, Natalia Vasquez-Canizares and Dawn M. Wahezi
    Citation: Pediatric Rheumatology 2023 21:82
    Content type: Research article Published on:

  39. Currently, monoarticular Juvenile Idiopathic Arthritis (monoJIA) is included in the ILAR classification as oligoarticular subtype although various aspects, from clinical practice, suggest it as a separate entity.

    Authors: Francesco Zulian, Beatrice Pierobon, Maria Elisabetta Zannin, Caterina Politi, Fabio Vittadello, Alessandra Meneghel, Francesca Tirelli and Giorgia Martini
    Citation: Pediatric Rheumatology 2023 21:81
    Content type: Research article Published on:

  40. To review whether the current COVID-19 vaccines can prevent the occurrence of multisystem inflammatory syndrome in children (MIS-C) and adolescents.

    Authors: Mohamad Hamad Saied, Laura van der Griend, Joeri W van Straalen, Nico M. Wulffraat, Sebastiaan Vastert and Marc H A Jansen
    Citation: Pediatric Rheumatology 2023 21:80
    Content type: Review Published on:

  41. Kawasaki disease (KD) is an acute pediatric vasculitis affecting genetically susceptible infants and children. Although the pathogenesis of KD remains unclear, growing evidence links genetic susceptibility to ...

    Authors: Xing Zhang, Ying Sun, Lijuan Meng, Caixia Ye, Huifeng Han, Tiesong Zhang, Yue Feng, Jianxiao Li, Lifen Duan and Yanfei Chen
    Citation: Pediatric Rheumatology 2023 21:78
    Content type: Research article Published on:

  42. C1-C2 subluxation is a rare complication of enthesitis-related arthritis (ERA). If left untreated, it may lead to functional impairment or cervical spinal cord compression. This study aims to highlight key poi...

    Authors: Wing Hin Stanford Siu, Chao-Jan Wang, Chieh-Tsai Wu, Chao-Yi Wu and Liang-Shiou Ou
    Citation: Pediatric Rheumatology 2023 21:77
    Content type: Case Report Published on:

  43. Evidence for the treatment of multisystem inflammatory syndrome in children (MIS-C) is lacking. Anakinra, which targets IL-1-mediated inflammation, is reserved for refractory cases of MIS-C; however, its use i...

    Authors: Brian L.P. Dizon, Christopher Redmond, Emily C. Gotschlich, Sangeeta Sule, Tova Ronis, Kathleen M. Vazzana, Matthew A. Sherman, Rachael Connor, Abigail Bosk, Niti Dham, Ashraf S. Harahsheh, Elizabeth Wells, Roberta DeBiasi and Hemalatha Srinivasalu
    Citation: Pediatric Rheumatology 2023 21:76
    Content type: Research article Published on:

  45. Juvenile idiopathic arthritis (JIA) is a common pediatric rheumatic condition and is associated with symptoms such as joint pain that can negatively impact health-related quality of life. To effectively manage...

    Authors: Karine Toupin-April, Isabelle Gaboury, Laurie Proulx, Adam M. Huber, Ciarán M. Duffy, Esi M. Morgan, Linda C. Li, Elizabeth Stringer, Mark Connelly, Jennifer E. Weiss, Michele Gibbon, Hannah Sachs, Aditi Sivakumar, Alexandra Sirois, Emily Sirotich, Natasha Trehan…
    Citation: Pediatric Rheumatology 2023 21:74
    Content type: Research article Published on:

  46. Immunization with meningococcal ACWY conjugate vaccine induces protective antibodies against invasive meningococcal disease (IMD) caused by serogroups A, C, W and Y. We studied MenACWY-TT vaccine immunogenicit...

    Authors: Milou Ohm, Joeri W van Straalen, Gerrie de Joode-Smink, Joris van Montfrans, Marije Bartels, Joanne G van Wildenbeest, Caroline A Lindemans, Roos AW Wennink, Joke H de Boer, Elisabeth AM Sanders, Frans M Verduyn-Lunel, Guy AM Berbers, Nico M Wulffraat and Marc H.A. Jansen
    Citation: Pediatric Rheumatology 2023 21:73
    Content type: Short Report Published on:

  47. Rheumatoid factor (RF)-positive polyarthritis is the least common type of juvenile idiopathic arthritis (JIA). Functional disability in RF-positive polyarthritis patients is much more severe than in patients w...

    Authors: Semanur Ozdel, Hafize Emine Sönmez, Şengül Çağlayan, Özlem Akgün, Tuncay Aydın, Özge Baba, İlknur Bağrul, Gülçin Otar Yener, Kübra Öztürk, Ferhat Demir, Deniz Gezgin Yıldırım, Şerife Gül Karadağ, Esra Bağlan, Mustafa Çakan, Mukaddes Kalyoncu, Balahan Bora Makay…
    Citation: Pediatric Rheumatology 2023 21:72
    Content type: Research article Published on:

  48. Primary immunodeficiencies are immunological disorders caused by gene mutations involved in immune system development and activation. Recently, activated phosphoinositide 3-kinase delta syndrome (APDS) due to ...

    Authors: Niloofar Shashaani, Zahra Chavoshzadeh, Leila Ghasemi, Shabnam Hajiani Ghotbabadi, Sara Shiari, Samin Sharafian and Reza Shiari
    Citation: Pediatric Rheumatology 2023 21:71
    Content type: Case Report Published on:

  49. CLUSTER is a UK consortium focussed on precision medicine research in JIA/JIA-Uveitis. As part of this programme, a large-scale JIA data resource was created by harmonizing and pooling existing real-world stud...

    Authors: Saskia Lawson-Tovey, Samantha Louise Smith, Nophar Geifman, Stephanie Shoop-Worrall, Sandra Ng, Michael R. Barnes, Lucy R. Wedderburn and Kimme L. Hyrich
    Citation: Pediatric Rheumatology 2023 21:70
    Content type: Research article Published on:

  50. Approximately one third of children with JIA receive biologic therapy, but evidence on biologic therapy withdrawal is lacking. This study aims to increase our understanding of whether and when pediatric rheuma...

    Authors: Janine A. van Til, Michelle M. A. Kip, Ellen J. H. Schatorjé, Gillian Currie, Marinka Twilt, Susanne M. Benseler, Joost F. Swart, Sebastiaan J. Vastert, Nico Wulffraat, Rae S. M. Yeung, C. G. M. (Karin) Groothuis-Oudshoorn, Sanne Warta, Deborah A. Marshall and Maarten J. IJzerman
    Citation: Pediatric Rheumatology 2023 21:69
    Content type: Research article Published on:

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Pediatric Rheumatology

ISSN: 1546-0096