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- Open Access
Dosing patterns of canakinumab in patients with Cryopyrin-Associated Periodic Syndromes (CAPS): A comparative analysis of a study in Western versus Japanese patients
https://doi.org/10.1186/1546-0096-9-S1-P12
© Bader-Meunier et al; licensee BioMed Central Ltd. 2011
- Published: 14 September 2011
Keywords
- Japanese Patient
- Western Population
- Frequent Dose
- Japanese Study
- Sustained Response
Background
CAPS is an orphan auto-inflammatory disease, generally diagnosed in childhood that requires life-long treatment. Canakinumab, a fully human anti-IL-1b antibody, has previously demonstrated rapid, complete and sustained response in CAPS patients.
Aim
To compare dosing patterns of canakinumab in pediatric and adult CAPS patients of a predominantly Western population (WP) vs Japanese patients (JP).
Methods
Step-wise up-titrations in patients (WP and Japanese) who did not achieve or remain in complete response
Results
Canakinumab doses by phenotypes
Phenotype (n=WP/JP) | Wester population | Japanese population | ||
---|---|---|---|---|
Adult1 Mean/median (mg) (N=136) | Pediatrics2 Mean/mdeian (mg/kg) (N=29) | Adult1 Mean/median (mg) (N=8) | Pediatrics2 Mean/mdeian (mg/kg) (N=11) | |
MWS (103/7) | 200/150 | 5.5/4.0 | 225/150 | 6.0/6.0 |
NOMID (32/11) | 299/150 | 5.8/4.0 | 300/225 | 5.5/6.0 |
FCAS (30/0) | 189/150 | 2.7/2.0 | - | - |
Conclusions
Increased doses of canakinumab were equally efficacious in patients of a WP and Japanese population comprising different CAPS phenotypes without evidence of a change in AE profile. These data suggest that children and patients with more severe CAPS phenotypes, irrespective of ethnicity, require differential dosing.
Authors’ Affiliations
Copyright
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.