Bone mineral density improvement after one year of treatment with etanercept in patients with juvenile idiopathic arthritis
© Susic et al; licensee BioMed Central Ltd. 2008
Published: 15 September 2008
Multiple risk factors are playing role in development of osteopenia in JIA. One of the most important is inflammatory nature of disease. Etanercept induces rapid and sustained suppression of JIA disease activity and could have protective effect on bone.
Aim of the study
To assess influence of etanercept on bone mineral density (BMD) in patients with JIA.
Patients and methods
In prospective study of 37 JIA pts (26 F, 11 M), mean age 16,3 yrs. with polyarthicular course, we have assessed BMD and bone mineral content (BMC) by dual x-ray absorptiometry on the lumbar spine (L2–L4) before and one or two years (in 13 pts) after introduction of etanercept.
after 1st year
BMD vol (g/cm3)*
After the first year of treatment we have noticed significant improvement of all ostedensitometric values. Mean value difference for BMD, compare to baseline was 7,1% (p < 0,001) for Z score 17,76% (p = 0,002), for BMC 13,13% (p < 0,001) and for BMDvol 5% (p < 0,001). Bone mineral status continued to increase during the second years of treatment as well (13 pts) (p < 0,001).
Our results demonstrated efficacy of etanercept, as TNF blocker, in improving bone mineral status and precluding of osteoporosis development in children with JIA. This beneficial effect on bone was demonstrated on the end of second year of treatment.
This article is published under license to BioMed Central Ltd.