Skip to main content

Advertisement

Methotrexate shows the same efficacy and safety in the real world in all subtypes of JIA as in the controlled trial

Article metrics

  • 716 Accesses

Background

Methotrexate (MTX) is the mostly used second line agent to treat Juvenile idiopathic arthritis (JIA). This study presents a retrospective data evaluation.

Objectives

To prove the efficacy and safety of MTX in all subtypes of JIA in a retrospective cohort.

Methods

Single center open-label evaluation of the efficacy and safety of MTX treatment in patients with JIA where treatment was initiated between 31 st of March 2005 and 31 st of December 2007.

Results

105 patients were MTX initiated aged between 1 to 17 years. 61 of them were female (58.1%). The mean treatment duration was 13.9 months. The mean MTX dose was 14.7 mg/m2/week. The response to therapy is shown in table 1, response occurred at months 3 and stayed stable over the observation period.

Table 1 Table 1

Adverse effects (AE) were reported by 41% of the patients, which were evenly distributed over the observation period. One severe AE occurred, one patient died with ALL.

Discussion

In this real world retrospective study of all JIA subsets MTX appears to be a safe and effective drug.

Author information

Correspondence to I Foedvari.

Rights and permissions

Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and Permissions

About this article

Keywords

  • Public Health
  • Adverse Effect
  • Arthritis
  • Retrospective Study
  • Methotrexate