Skip to main content
  • Poster presentation
  • Open access
  • Published:

Attacks of severe dysmenorrhea as the sole manifestation of Familial Mediterranean Fever (FMF)

Familial Mediterranean Fever (FMF) is an autosomal recessive disease (MEFV gene) characterized by recurrent fever and inflammatory serositis. Although majority of patients have random pattern of attacks, some reports described precipitating factors. A literature review indicated that FMF attacks occurring only during menstruation are rarely seen. We report the cases of three patients with severe dysmenorrhoic pain as unusual clinical presentation of FMF. They were 3 females with a mean age at onset of 12 years. They never had typical attacks of fever and abdominal or chest pain, but they suffered from regular and severe dysmenorrhoic pain. Leukocytosis and C-reactive protein (CRP) elevation were noted during these attacks in all patients. Unlike dysmenorrhoea, none of these patients' attacks responded to non-steroidal anti-inflammatory drugs. The diagnosis of FMF was based on typical clinical and laboratory features. On investigation of MEFV, M694V was the most frequent mutation

All patients responded well to colchicine, and amyloidosis was not documented in any patients.

In conclusion, we suggest that gynecologists must be aware of FMF in the differential diagnosis of dysmenorrhoea or endometriosis especially in the people of Mediterranean origin.[1]


  1. Akar S, Soyturk M, Onen F, Tunca M: The relations between attacks and menstrual periods and pregnancies of familial Mediterranean fever patients. Rheumatol Int. 2006, 26 (7): 676-9. 10.1007/s00296-005-0041-z.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and permissions

About this article

Cite this article

Vitale, A., La Torre, F., Caruso, C. et al. Attacks of severe dysmenorrhea as the sole manifestation of Familial Mediterranean Fever (FMF). Pediatr Rheumatol 6 (Suppl 1), P177 (2008).

Download citation

  • Published:

  • DOI: