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  • Open Access

A rare case of sarcoid osteitis in a child with response to methotrexate

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Pediatric Rheumatology20086 (Suppl 1) :P139

  • Published:


  • Methotrexate
  • Sarcoidosis
  • Lymph Node Biopsy
  • Cervical Lymph Node
  • Bone Involvement

Sarcoidosis is a disease of unknown origin characterised by noncaseating granuloma and can involve any tissue or organ. Osseous involvement in sarcoidosis is rare in children and long tubular bone involvement is even rarer. We present a case histologically proven as sarcoid osteitis of radius and humerus that had a dramatic response to methotrexate.

A 9 year old Jamaican boy with known sarcoidosis, diagnosed in Kingston by cervical lymph node biopsy initially presented to us with high grade pyrexia, peripheral lymphadenopathy and painful shiny swelling in both shin. Tentative diagnosis made was sarcoid related osteitis. X-ray of legs (Figure 1) showed periosteal reaction in leg bones. He was treated with subcutaneous methotrexate.
Figure 1
Figure 1

X-ray of legs showing periosteal reaction in leg bones.

After 3 years of drug-induced remission, methotrexate was stopped. Eight months after stopping methotrexate he presented with painful swelling of left arm and forearm. Radiograph showed circumferential lesion with periosteal reaction and MRI scan confirmed surrounding oedema suggestive of acute lesion. Sarcoid osteitis was confirmed on biopsy by the presence of characteristic non caseating granuloma with giant cells. He was restarted on methotrexate upon which the lesions resolved in a few weeks.

Authors conclude that long bone involvement in a child with sarcoidosis is rare but we should have low threshold for biopsy in known case of sarcoidosis presenting with radiological feature of osteitis to confirm the diagnosis and for treatment. In our case there was excellent response to methotrexate.

Authors’ Affiliations

Queen's Medical Centre, Nottingham University Hospitals, Nottingham, UK


  1. Marvisi M: Osteoarticular sarcoidosis. Minerva Med. 1998, 89 (5): 169-72.PubMedGoogle Scholar


© Goel et al; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.