Volume 13 Supplement 1
MAGIC- is it for real?
© Damian et al. 2015
Published: 28 September 2015
MAGIC syndrome, an acronym for mouth and genital ulcers with inflammed cartilage, is a rare condition described in 1985 . About 20 cases have been reported , and its existence is challenged, as it could be just a mere association of Bechet's disease (BD) with relapsing polychondritis (RP) . Other authors, however, consider it a distinct entity with higher risk of aortic aneurysms . We tried to find out whether this syndrome is a true nosologic entity.
Clinical features of MAGIC patients in our series
oral aphtae since youth; genital aphtae, deep vein thrombosis, migratory seronegative polyarthritis, reccurent bilateral auricular chondritis, wheesing
Lost to follow-up (after 2 years)
bipolar aphtae, asymmetric sacroiliitis, acneiform rash, intermittent seronegative polyarthritis, gastrointestinal involvement, bilateral auricular and nasal chondritisANA positive, dsDNA negative
Lost to follow-up (after 3 years- emigrated)
bipolar aphtae, pseudofolliculitis, erythema nodosum, arthritis, panniculitis, recurrent auricular chondritis, nasal chondritis, positive cartilage biopsy
Rare chondritis flares
RP and BD have overlapping features and may share pathogenetic mechanisms. The same time of onset of the main MAGIC clinical features could favour the classification of the disease as distinct from RP and BD alone. However, in our small and incompletely followed-up series aortic aneurysms were not seen, like in other MAGIC cases reported. An aortic follow-up is nevertheless advisable, as in any RP.
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