MAGIC- is it for real?
© Damian et al. 2015
Published: 28 September 2015
MAGIC syndrome, an acronym for mouth and genital ulcers with inflammed cartilage, is a rare condition described in 1985 . About 20 cases have been reported , and its existence is challenged, as it could be just a mere association of Bechet's disease (BD) with relapsing polychondritis (RP) . Other authors, however, consider it a distinct entity with higher risk of aortic aneurysms . We tried to find out whether this syndrome is a true nosologic entity.
Clinical features of MAGIC patients in our series
oral aphtae since youth; genital aphtae, deep vein thrombosis, migratory seronegative polyarthritis, reccurent bilateral auricular chondritis, wheesing
Lost to follow-up (after 2 years)
bipolar aphtae, asymmetric sacroiliitis, acneiform rash, intermittent seronegative polyarthritis, gastrointestinal involvement, bilateral auricular and nasal chondritisANA positive, dsDNA negative
Lost to follow-up (after 3 years- emigrated)
bipolar aphtae, pseudofolliculitis, erythema nodosum, arthritis, panniculitis, recurrent auricular chondritis, nasal chondritis, positive cartilage biopsy
Rare chondritis flares
RP and BD have overlapping features and may share pathogenetic mechanisms. The same time of onset of the main MAGIC clinical features could favour the classification of the disease as distinct from RP and BD alone. However, in our small and incompletely followed-up series aortic aneurysms were not seen, like in other MAGIC cases reported. An aortic follow-up is nevertheless advisable, as in any RP.
- Firestein GS, Gruber E, Weisman MH, Zvaifler NJ, Barber J, O'Duffy JD: Mouth and genital ulcers with inflamed cartilage: MAGIC syndrome. Am J Med. 1985, 79 (1): 65-72. 10.1016/0002-9343(85)90547-9.View ArticlePubMedGoogle Scholar
- Wajed J, Kiely P: 19. Could it be Magic?. Rheumatology. 2011, 50 (Suppl 3): iii43-iii50.Google Scholar
- Kotter J, Deuter C, Gunaydin I, Zierhut M: MAGIC or not MAGIC (mouth and genital ulcers with inflamed cartilage) syndrome really exists? A case report and review of the literature. Clin Exp Rheumatol. 2006, 24 (5 Suppl 42): S108-S112.PubMedGoogle Scholar
- Hidalgo-Tenorio C, Sabio-Sanchez JM, Linares PJ, Salmeron LM, Ros-die E, Jimenez-Alonso J: Magic syndrome and true aortic aneurysm. Clin Rheumatol. 2008, 27 (1): 115-117.View ArticlePubMedGoogle Scholar
- Kronborg C, Mahar PD, Kelly R: Should we keep changing the diagnostic criteria for Behcet's disease?. Dermatology. 2014, 228 (1): 1-4. 10.1159/000355481.View ArticlePubMedGoogle Scholar
- Damiani JM, Levine HL: Relapsing polychondritis- report of ten cases. Laryngoscope. 1979, 89 (6 Pt 1): 929-946.PubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.