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How safe it is to treat pregnant FMF patients with Anakinra?
Pediatric Rheumatology volume 13, Article number: P124 (2015)
Background
It has been reported that anakinra, an anti-IL-1R antagonist, may be a safe alternative during pregnancy in patients with various autoinflammatory syndromes (1,2).
Objectives
To assess the safety and efficacy of anakinra in pregnant FMF patients.
Methods
Five FMF patients, treated with anakinra during pregnancy were monitored for side effects, fetal and maternal outcomes.
Results
We present five FMF cases treated with Anakinra during pregnancy due to severe protracted febrile myalgia in 3, thrombocytopenia in 1 and amyloidosis in 1. One of these cases is among the 5 patients that have been previously reported (1). Throughout pregnancy no anakinra-related adverse event was observed in any of the patients. During the postpartum period one patient had an incision-site infection and the baby of the patient with thrombocytopenia also developed low platelet count which resolved with IVIG therapy. Otherwise all patients delivered normal babies. One of the patients is still pregnant and expecting twins. All of the patients, except one with colchicine intolerance continued with daily prophylactic colchicine treatment. Anakinra was terminated shortly after birth with success in all. Pregnancy-related features are listed in Table 1.
Conclusions
Anakinra promises to be a safe alternative in pregnant FMF patients who are unresponsive or intolerant to colchicine. It can be administered transiently only during pregnancy and stopped after delivery.
References
Lachman HJ, et al: Pediatric Rheumatology. 2013, 11 (Suppl1): A269-
Chang Z, et al: Arthritis Rheumatol. 2014
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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Ozdogan, H., Ugurlu, S. & Ergezen, B. How safe it is to treat pregnant FMF patients with Anakinra?. Pediatr Rheumatol 13 (Suppl 1), P124 (2015). https://doi.org/10.1186/1546-0096-13-S1-P124
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DOI: https://doi.org/10.1186/1546-0096-13-S1-P124