Skip to main content
  • Poster presentation
  • Open access
  • Published:

Clinical manifestations of four patients diagnosed with early-onset sarcoidosis or sarcoid-like syndrome


Sarcoidosis is a rare multisystemic granulomatous disease. Pulmonary involvement is common in adults, but any organ can be affected.


To describe the main features of 4 pediatric patients diagnosed with early-onset sarcoidosis (EOS) or sarcoid-like syndrome.


Medical charts were reviewed.


Four patients wer enrolled, 2 female (cases 1 and 2) and 2 male (cases 3 and 4). Their main characteristics are shown in table 1. The age at disease onset was 1.5, 10, 0.6 and 11 years respectively. The time until diagnosis ranged from 4 days to 8 years. The two cases with EOS (1 and 3) had been previously diagnosed as Juvenile Idiopathic Arthritis. Both started at a short age with the classical triad and carried a heterozygous gain-of-function NOD2 mutation. Patient 2 seemed to be a late-onset sarcoidosis but persistent hypogammaglobulinemia and poor antibody production suggested a CVID, despite she did not suffer from recurrent infections. Other granulomatous lung diseases were dismissed in this case. Finally, diagnosis in patient 4 was made according to his clinical manifestations and the slight increase in ACE level.

Table 1 Main features of the four enrolled children


Diagnosis of sarcoidosis in pediatric patients is often delayed because the disease is not suspected. Pulmonary involvement occurs less frequently in pediatric than in adults patients. This condition requires multidisciplinary management.

Disclosure of interest

None declared.

Author information

Authors and Affiliations


Rights and permissions

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Murias, S., Alcobendas, R., Remesal, A. et al. Clinical manifestations of four patients diagnosed with early-onset sarcoidosis or sarcoid-like syndrome. Pediatr Rheumatol 12 (Suppl 1), P293 (2014).

Download citation

  • Published:

  • DOI: