Clinical manifestations of four patients diagnosed with early-onset sarcoidosis or sarcoid-like syndrome

Table 1 Main features of the four enrolled children

	Clinical data	Analytical data	ACE	Non-caseating granulomata	Diagnosis
1	Arthritis, rash, uveitis	Heterozygous p.R334Q	27.5	Skin	EOS
		Mutation at NOD2 gene
2	Splenomegaly,	Lymphopenia			CVID
	lymphadenopathy,	Thrombocytopenia			Sarcoid like syndrome
	interstitial/nodular	Hypogammaglobulinemia	92	Lung
	lung disease	Poor antibody responses
3	Arthritis, rash, uveitis
		Heterozygous p.C495Y	19	Skin	Blau’s syndrome
		Mutation at NOD2 gene		Synovial
				Liver
4	Right facial paralysis, parotid enlargement, uveitis, high fever		74.8		Heerfordt’s syndrome

ISSN: 1546-0096