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  1. Treatment strategies for juvenile idiopathic arthritis (JIA) have shifted significantly over the last 20 years. We examined the effect of the introduction of government-subsidised TNF inhibitor (TNFi) treatmen...

    Authors: Erin Kelty, Ebony Quintrell, David B. Preen, Prue Manners and Johannes Nossent
    Citation: Pediatric Rheumatology 2023 21:29
  2. Lupus nephritis (LN) is a crucial organ involvement in systemic lupus erythematosus (SLE). Patients with LN have higher morbidity and mortality rates than those without. Among all patients with LN, 20–40% had ...

    Authors: Tzu-Chuan Hsu, Yao-Hsu Yang, Li-Chieh Wang, Jyh-Hong Lee, Hsin-Hui Yu, Yu-Tsan Lin, Ya-Chiao Hu and Bor-Luen Chiang
    Citation: Pediatric Rheumatology 2023 21:28
  3. Etanercept (ETN) is widely used tumour necrosis factor (TNF) blocker in the treatment of juvenile idiopathic arthritis (JIA) when traditional synthetic disease modifying antirheumatic drug (sDMARD) therapy is ...

    Authors: Tiina Levälampi, Johanna Kärki, Katariina Rebane, Paula Vähäsalo, Merja Malin, Liisa Kröger, Minna-Maija Grönlund, Maria Backström, Heini Pohjankoski, Hannu Kautiainen, Sakari Jokiranta and Kristiina Aalto
    Citation: Pediatric Rheumatology 2023 21:27
  4. In recent years, biologic drug therapies have altered the course of juvenile idiopathic arthritis (JIA) possibly also improving the patients’ physical fitness. However, studies measuring both cardiorespiratory...

    Authors: Kati Räsänen, Kati Markula-Patjas, Saija Kantanen, Kalle Sipilä, Timo A. Lakka, Pekka Arikoski and Eija Piippo-Savolainen
    Citation: Pediatric Rheumatology 2023 21:26
  5. Cytomegalovirus (CMV) plays an important role in the pathogenesis of systemic lupus erythematosus (SLE). However, it is not clear whether the anti-CMV treatment has an impact on the prognosis of SLE patients w...

    Authors: Tianyu Zhang, Zhongxun Yu, Sihao Gao, Yuelun Zhang, Changyan Wang, Shan Jian, Lin Wang, Lijuan Gou, Ji Li, Mingsheng Ma and Hongmei Song
    Citation: Pediatric Rheumatology 2023 21:25
  6. Despite guidelines, poor access to appropriate care for juvenile idiopathic arthritis (JIA) patients remains a global issue. Prompt referral to a pediatric rheumatology (PR) center and effective care is known ...

    Authors: Aurélie Chausset, Céline Lambert, Alexandre Belot, Etienne Merlin, Elvira Cannizzaro, Isabelle Kone-Paut, Claire Ballot, Valérie Devauchelle, Sylvaine Poignant, Raffaella Carlomagno, Anne Lohse, Catherine Barbier, Véronique Despert, Aurélia Carbasse, Laetitia Sparsa, Eva Adank…
    Citation: Pediatric Rheumatology 2023 21:24
  7. Blau syndrome is a rare autoinflammatory disease caused by autosomal dominant mutations in the CARD15/NOD2 gene. Vascular involvement is a rare phenotype in Blau syndrome patients. In this study, we aimed to d...

    Authors: Qiaoqian Zeng, Haimei Liu, Guomin Li, Yifan Li, Wanzhen Guan, Tao Zhang, Yinv Gong, Xiaomei Zhang, Qianying Lv, Bingbing Wu, Hong Xu and Li Sun
    Citation: Pediatric Rheumatology 2023 21:23
  8. The relationship between anti-SSA/RO antibodies and pregnancy has been reported previously, and we aim to visualize the rates of maternal and infant outcomes with anti-SSA/RO.

    Authors: Xiangrui Sheng, Xiaohui Song, Yue Xiong, Tian Ren, Xin Chang, Jian Wu, Jing Cao, Tao Cheng and Mingjun Wang
    Citation: Pediatric Rheumatology 2023 21:22
  9. Adalimumab in combination with other disease-modifying antirheumatic drugs (DMARD) such as methotrexate has a proven efficacy in the management of paediatric non-infectious uveitis. However, many children expe...

    Authors: DA Al-Julandani, NK Bagri, N Tsang, S Clarke, A Upadhyay, C Guly and AV Ramanan
    Citation: Pediatric Rheumatology 2023 21:21
  10. A systematic literature review was conducted to summarize efficacy and safety data from studies that evaluated tumor necrosis factor inhibitors in patients with juvenile idiopathic arthritis (JIA).

    Authors: Gerd Horneff, Kirsten Minden, Catherine Rolland, Ana C. Hernandez Daly, Cecilia Borlenghi and Nicolino Ruperto
    Citation: Pediatric Rheumatology 2023 21:20
  11. Little is known about the association between juvenile idiopathic arthritis (JIA) and autoimmune thyroid disease (AITD) and therefore there are no indications for AITD screening in this population, which is po...

    Authors: Joeri W. van Straalen, Laurie Baas, Gabriella Giancane, Lyudmila Grebenkina, Jurgen Brunner, Gabriel Vega-Cornejo, Vyacheslav G. Chasnyk, Liora Harel, Simone Appenzeller, Elisabeth Gervais, Sytze de Roock, Nico M. Wulffraat, Nicolino Ruperto and Joost F. Swart
    Citation: Pediatric Rheumatology 2023 21:19
  12. To evaluate the efficacy of levofolinic acid (LVF) administered 48 h before methotrexate (MTX) in reducing gastrointestinal side effects without interference with drug efficacy.

    Authors: Giorgia Martini, Alessandra Meneghel, Michele Fastiggi, Filippo Dell’Apa, Fabio Vittadello and Francesco Zulian
    Citation: Pediatric Rheumatology 2023 21:18
  13. Juvenile Idiopathic Arthritis (JIA) is an autoimmune disease with a heterogenous clinical presentation and unpredictable response to available therapies. This personalized transcriptomics study sought proof-of...

    Authors: Kathleen J. Imbach, Nicole J. Treadway, Vaishali Prahalad, Astrid Kosters, Dalia Arafat, Meixue Duan, Talia Gergely, Lori A. Ponder, Shanmuganathan Chandrakasan, Eliver E. B. Ghosn, Sampath Prahalad and Greg Gibson
    Citation: Pediatric Rheumatology 2023 21:17
  14. IgG4-related disease (IgG4-RD) is a progressive and sometimes fatal disease that rarely affects pediatric age group. It may affect the orbits, lacrimal and salivary glands, pancreas, kidneys, peritoneum and ot...

    Authors: Moustafa Ali Saad, Hamdy Ahmed, Rasmia Elgohary and Hala Ibrahem El Gendy
    Citation: Pediatric Rheumatology 2023 21:16
  15. Cryopyrin-associated periodic syndrome (CAPS), a rare genetic autoimmune disease, is composed of familial cold autoinflammatory syndrome (FCAs), Muckle-Wells syndrome (MWS), and neonatal onset multisystem infl...

    Authors: Jia Liu, Ranran Zhang, Zhi Yi, Yi Lin, Hong Chang and Qiuye Zhang
    Citation: Pediatric Rheumatology 2023 21:15
  16. Axial involvement in children with enthesitis-related arthritis (ERA) has characteristics that differ from those of peripheral involvement. This study characterized their clinical characteristics and treatment.

    Authors: Yanli Guo, Yuying Fang, Tonghao Zhang, Yuting Pan, Panpan Wang, Zhidan Fan and Haiguo Yu
    Citation: Pediatric Rheumatology 2023 21:13
  17. To characterize the clinical features and outcomes of childhood-onset primary Sjögren’s syndrome (pSS).

    Authors: Yinv Gong, Haimei Liu, Guomin Li, Tao Zhang, Yifan Li, Wanzhen Guan, Qiaoqian Zeng, Qianying Lv, Xiaomei Zhang, Wen Yao, Yu Shi, Hong Xu and Li Sun
    Citation: Pediatric Rheumatology 2023 21:11
  18. In a chronic pain-causing disease such as juvenile idiopathic arthritis, the quality of coping with pain is crucial. Parents have a substantial influence on their children’s pain-coping strategies. This study ...

    Authors: Maria Backström, Hanna Vuorimaa, Maarit Tarkiainen, Eliisa Löyttyniemi, Liisa Kröger, Kristiina Aalto, Katariina Rebane, Kati Markula-Patjas, Merja Malin, Sirja Sard, Paula Keskitalo, Katja Korkatti, Minna-Maija Grönlund, Milja Möttönen, Heini Pohjankoski, Maiju Hietanen…
    Citation: Pediatric Rheumatology 2023 21:9
  19. Camptodactyly-arthropathy-coxa vara-pericarditis (CACP) syndrome, caused by biallelic pathogenic mutations in the proteoglycan 4 (PRG4) gene, is characterized by early-onset camptodactyly, noninflammatory arthrop...

    Authors: İlknur Bağrul, Serdar Ceylaner, Yasemin Tasci Yildiz, Serife Tuncez, Elif Arslanoglu Aydin, Esra Bağlan, Semanur Ozdel and Mehmet Bülbül
    Citation: Pediatric Rheumatology 2023 21:8
  20. Dry synovitis (DS) is a rare entity as only a few cases have been reported to date. We describe the clinical features, radiological manifestations and course of DS in comparison with rheumatoid factor negative...

    Authors: Lien De Somer, Brigitte Bader-Meunier, Sylvain Breton, Sara Brachi, Carine Wouters and Francesco Zulian
    Citation: Pediatric Rheumatology 2023 21:7
  21. Delay in diagnosis and access to specialist care is a major problem for many children and young people with rheumatic disease in sub-Saharan Africa. Most children with symptoms of rheumatic disease present to ...

    Authors: Angela Migowa, Sasha Bernatsky, Anthony Ngugi, Helen E. Foster, Peter Muriuki, Adelaide Lusambili and Stanley Luchters
    Citation: Pediatric Rheumatology 2023 21:6
  22. In the midst of the COVID-19 coronavirus pandemic, a new disease that affects children has arisen called multisystem inflammatory syndrome in children (MIS-C). Several research articles focusing on its medical as...

    Authors: Henrik Hjelmgren, Karin Andersson, Jessica Widegren, Erika Bergman, Anna Vermé, Karina Mördrup, Marcus Öhlander and Cecilia Bartholdson
    Citation: Pediatric Rheumatology 2023 21:5
  23. Familial Mediterranean Fever (FMF) is the most common monogentic autoinflammatory disease. FMF results from mutations in MEFV, which lead to a pro-inflammatory state and increased production of Interleukin 1 beta...

    Authors: Shiran Pinchevski-Kadir, Maya Gerstein, Oren Pleniceanu, Yonatan Yacobi, Asaf Vivante, Ortal Erez Granat, Shiri Spielman, Rotem Semo Oz and Irit Tirosh
    Citation: Pediatric Rheumatology 2023 21:4
  24. Despite new and better treatments for juvenile dermatomyositis (JDM), not all patients with moderate severity disease respond adequately to first-line therapy. Those with refractory disease remain at higher ri...

    Authors: Matthew A. Sherman, Hanna Kim, Katelyn Banschbach, Amanda Brown, Harry L. Gewanter, Bianca Lang, Megan Perron, Angela Byun Robinson, Jacob Spitznagle, Cory Stingl, Grant Syverson, Heather O. Tory, Charles H. Spencer and Stacey E. Tarvin
    Citation: Pediatric Rheumatology 2023 21:3
  25. Familial Mediterranean Fever (FMF) patients are required to adhere to a life-long treatment with colchicine, primarily for preventing amyloidosis. As some patients may be asymptomatic for long periods of time,...

    Authors: Keren Cohen, Shiri Spielman, Rotem Semo-Oz, Guy Bitansky, Maya Gerstein, Yonatan Yacobi, Asaf Vivante and Irit Tirosh
    Citation: Pediatric Rheumatology 2023 21:2
  26. A significant number of patients in pediatric rheumatology suffer from ongoing disease activity into adulthood and thus need to be transferred into adult care. Transition as a structured individual process of ...

    Authors: Luca Samuel Boeker, Jasmin Beate Kuemmerle-Deschner, Sebastian Jonas Saur, Jens Klotsche, Gabriele Erbis and Sandra Hansmann
    Citation: Pediatric Rheumatology 2022 20:121
  27. Ethosuximide and other anti-epileptic drugs have been reported to cause idiosyncratic reactions such as lupus-like syndromes, with elevated antinuclear antibody (ANA) levels. Herein, we present a case of a gir...

    Authors: Lillemor Berntson and Gunnar Liminga
    Citation: Pediatric Rheumatology 2022 20:120
  28. Kawasaki disease (KD) is usually treated with high-dose intravenous immunoglobulin (IVIg) as severe infectious and other diseases. Due to issues that are associated with immunoglobulin preparation, such as the...

    Authors: Fuyu Ito, Toshiaki Oharaseki, Daisuke Tsukui, Yoshitaka Kimura, Tamiko Yanagida, Fukuko Kishi, Yoshio Yamakawa, Yosuke Kameoka, Shoichi Suzuki, Kazuko Uno, Osamu Suzuki, Noriko N. Miura, Naohito Ohno, Kei Takahashi, Hajime Kono and Kazuo Suzuki
    Citation: Pediatric Rheumatology 2022 20:119
  29. Adenosine deaminase 2 (ADA2) deficiency is an inherited autoinflammatory syndrome caused by a defect in the ADA2 gene. Most common manifestations include peripheral vasculopathy, early-onset stroke, immunodeficie...

    Authors: Z. Lucane, Z. Davidsone, I. Micule, M. Auzenbaha and N. Kurjane
    Citation: Pediatric Rheumatology 2022 20:118
  30. Haptoglobin (Hp), a liver derived acute phase inflammatory protein (APP), has scarcely been studied in juvenile idiopathic arthritis (JIA). Hp can occur in blood as two isoforms (Hp1 and Hp2) in precursor and...

    Authors: Lillemor Berntson, Jakob Palm, Fredrik Axling, Peter Zarelius, Per M. Hellström and Dominic-Luc Webb
    Citation: Pediatric Rheumatology 2022 20:117
  31. Authors: Timothy Hahn, Carrie Daymont, Timothy Beukelman, Brandt Groh, Kimberly Hays, Catherine April Bingham and Lisabeth Scalzi
    Citation: Pediatric Rheumatology 2022 20:116

    The original article was published in Pediatric Rheumatology 2022 20:107

  32. Incomplete Kawasaki disease (IKD) initially presenting as retropharyngeal abnormality is very rare and is prone to misdiagnosis and missed diagnosis, often leading to poor prognosis. Most patients were misdiag...

    Authors: Yong-chao Chen, Hong-guang Pan, De-sheng Jia, Hao-cheng Wang, Lan Li and Yi-shu Teng
    Citation: Pediatric Rheumatology 2022 20:115
  33. Children with chronic diseases are reported to have increased risk of psychiatric comorbidity. Few studies have investigated this risk in juvenile idiopathic arthritis (JIA), with conflicting results. We perfo...

    Authors: Elisabet Berthold, Alma Dahlberg, Anna Jöud, Helena Tydén, Bengt Månsson, Fredrik Kahn and Robin Kahn
    Citation: Pediatric Rheumatology 2022 20:114
  34. The Childhood Arthritis and Rheumatology Research Alliance (CARRA) developed consensus treatment plans (CTPs) to compare treatment initiation strategies for systemic juvenile idiopathic arthritis (sJIA). First...

    Authors: Timothy Beukelman, George Tomlinson, Peter A. Nigrovic, Anne Dennos, Vincent Del Gaizo, Marian Jelinek, Mary Ellen Riordan, Laura E. Schanberg, Shalini Mohan, Erin Pfeifer and Yukiko Kimura
    Citation: Pediatric Rheumatology 2022 20:113
  35. Multisystem inflammatory syndrome in children (MIS-C) is a new syndrome with some clinical manifestations similar to Kawasaki disease (KD), which is difficult to distinguish.

    Authors: Tong Tong, Xuefeng Yao, Zhe Lin, Yijing Tao, Jiawen Xu, Xiao Xu, Zhihao Fang, Zhimin Geng, Songling Fu, Wei Wang, Chunhong Xie, Yiying Zhang, Yujia Wang and Fangqi Gong
    Citation: Pediatric Rheumatology 2022 20:112
  36. The most severe complication associated with giant coronary aneurysm in children with Kawasaki disease is ischemic cardiomyopathy (ICM) caused by thrombosis. Addition of tissue plasminogen activator, Alteplase...

    Authors: Yanqiu Chu, Yunming Xu, Ce Wang, Xiaona Yu, Quanmei Ma and Hong Wang
    Citation: Pediatric Rheumatology 2022 20:111
  37. Since the onset of the recent COVID-19 pandemic, there have been growing concerns regarding multisystem inflammatory syndrome in children (MIS-C). This study aims to describe the clinico-epidemiological profil...

    Authors: Angela Migowa, Pauline Samia, Sean del Rossi, Oliver Ombeva Malande, Jasmit Shah, Chemutai Kenei, Joy Ayaya, Daisy Jeruto, Laura Oyiengo and Laura Lewandowski
    Citation: Pediatric Rheumatology 2022 20:110
  38. Biologic disease-modifying antirheumatic drugs (bDMARDs) have changed the treatment of juvenile idiopathic arthritis (JIA) patients notably, as bDMARDs enable substantially more patients to achieve remission. ...

    Authors: Job Gieling, Bart van den Bemt, Esther Hoppenreijs and Ellen Schatorjé
    Citation: Pediatric Rheumatology 2022 20:109
  39. Chronic Recurrent Multifocal Osteomyelitis (CRMO) is an autoinflammatory bone disorder with predominantly paediatric onset. Children present with multifocal osteolytic lesions accompanied by bone pain and soft...

    Authors: Dita Cebecauerová, Hana Malcová, Veronika Koukolská, Zuzana Kvíčalová, Ondřej Souček, Lukáš Wagenknecht, Jiří Bronský, Zdeněk Šumník, Martin Kynčl, Marek Cebecauer and Rudolf Horváth
    Citation: Pediatric Rheumatology 2022 20:108
  40. Children with juvenile idiopathic arthritis (JIA) who achieve a drug free remission often experience a flare of their disease requiring either intraarticular steroids (IAS) or systemic treatment with disease m...

    Authors: Timothy Hahn, Carrie Daymont, Timothy Beukelman, Brandt Groh, Kimberly Hays, Catherine April Bingham and Lisabeth Scalzi
    Citation: Pediatric Rheumatology 2022 20:107

    The Publisher Correction to this article has been published in Pediatric Rheumatology 2022 20:116

  41. Autoinflammatory diseases are rare disorders of the innate immune system characterized by fever and other signs of inflammation. A feared complication of autoinflammatory diseases is the development of AA amyl...

    Authors: G. E. Legger, C. W. E. Dermer, A. F. Brunger, P. L. A. van Daele and H. L. A. Nienhuis
    Citation: Pediatric Rheumatology 2022 20:106
  42. There is growing concern about the long-term cardiovascular health of patients with juvenile idiopathic arthritis (JIA). In this study we assessed the association between JIA polygenic risk and cardiovascular ...

    Authors: Sarah L. N. Clarke, Hannah J. Jones, Gemma C. Sharp, Kayleigh E. Easey, Alun D. Hughes, Athimalaipet V. Ramanan and Caroline L. Relton
    Citation: Pediatric Rheumatology 2022 20:105
  43. Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening condition of immune dysregulation primarily driven by the cytokine interferon gamma. It can be either a genetic or acquired disorder associated wi...

    Authors: Allison Guild, Jordan Fritch, Sachit Patel, Adam Reinhardt and Melissa Acquazzino
    Citation: Pediatric Rheumatology 2022 20:104
  44. Little is known about the disposition to autoimmune diseases (ADs) among children diagnosed with JIA. In this study, we provide a comprehensive overview of the prevalence of and factors associated with ADs in ...

    Authors: Joeri W. van Straalen, Sytze de Roock, Gabriella Giancane, Ekaterina Alexeeva, Elena Koskova, Pablo Mesa-del-Castillo Bermejo, Francesco Zulian, Adele Civino, Davide Montin, Nico M. Wulffraat, Nicolino Ruperto and Joost F. Swart
    Citation: Pediatric Rheumatology 2022 20:103
  45. The epidemiology and clinical presentation of systemic juvenile idiopathic arthritis (sJIA) in the Afro-Caribbean population is not well described.

    Authors: A. Felix, F. Delion, B. Suzon, S. Pallara-Sirven, N. Elenga, P. Quartier, F. Louis-Sidney, M. Dramé and Y. Hatchuel
    Citation: Pediatric Rheumatology 2022 20:98
  46. Evaluation of costs and short-term cost-effectiveness of infliximab plus methotrexate (IFX + MTX); triple therapy of hydroxychloquine, sulphasalazine, and methotrexate (TRIPLE); or methotrexate monotherapy (MT...

    Authors: Maarit Tarkiainen, Pirjo Tynjälä, Paula Vähäsalo, Kristiina Aalto, Liisa Kröger, Katariina Rebane, Pekka Lahdenne and Janne Martikainen
    Citation: Pediatric Rheumatology 2022 20:97

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