Articles

Usefulness of magnetic resonance enterography in detecting signs of sacroiliitis in young patients with inflammatory bowel disease

Arthritis is often an underestimated extraintestinal manifestation in pediatric inflammatory bowel disease (IBD), including sacroiliitis, whose early signs are well detectable at magnetic resonance imaging (MR...

Authors: Teresa Giani, Azzurra Bernardini, Massimo Basile, Marco Di Maurizo, Anna Perrone, Sara Renzo, Viola Filistrucchi, Rolando Cimaz and Paolo Lionetti

Assessing the reporting quality of physical activity programs in randomized controlled trials for the management of juvenile idiopathic arthritis using three standardized assessment tools

The reporting quality of physical activity (PA) programs in randomized controlled trials (RCTs) for the management of juvenile idiopathic arthritis (JIA) remains unknown. This study aimed to assess and compare...

Authors: Teresa-Rose Kattackal, Sabrina Cavallo, Lucie Brosseau, Aditi Sivakumar, Michael J. Del Bel, Michelle Dorion, Erin Ueffing and Karine Toupin-April

Recurrent Henoch-Schönlein Purpura with bullous rash and pulmonary nodules

Henoch-Schönlein purpura (HSP) is the most common vasculitis of childhood. It has a characteristic rash described as palpable purpura that most frequently affects the distal lower extremities and buttocks. HSP...

Authors: Christopher Zheng, Julie Childers, Egla Rabinovich and Kristina Nazareth-Pidgeon

Nephrological disorders and neurological involvement in pediatric primary Sjogren syndrome:a case report and review of literature

Sjögren syndrome (SS) is a rare disease in pediatrics, and little attention has been paid to the clinical feature in these patients. To date, there are few cases concern about neurological and nephrological di...

Authors: Jingya Zhao, Qin Chen, Yunyun Zhu, Meng Zhao, Jun Liu, Zhenzhong Zhang and Xiaoting Gong

The association of MEFV gene mutations with the disease risk and severity of systemic juvenile idiopathic arthritis

Systemic juvenile idiopathic arthritis (sJIA) has many clinical features overlapping with familial Mediterranean fever (FMF), which is caused by mutations in MEFV gene. And FMF patients were easily misdiagnosed a...

Authors: Linqing Zhong, Wei Wang, Ji Li, Mingsheng Ma, Lijuan Gou, Changyan Wang, Zhongxun Yu, Tiannan Zhang, Yanqing Dong, Qijiao Wei and Hongmei Song

Type 1 interferonopathy presenting as juvenile idiopathic arthritis with interstitial lung disease: report of a new phenotype

STING-associated vasculopathy with onset in infancy (SAVI) is a type 1 interferonopathy manifesting as a pulmonary and vascular syndrome resulting from gain-of-function mutations in TMEM173, the gene encoding STI...

Authors: S. L. N. Clarke, L. Robertson, G. I. Rice, L. Seabra, T. N. Hilliard, Y. J. Crow and A. V. Ramanan

Feasibility and acceptability of an innovative adherence intervention for young adults with childhood-onset systemic Lupus Erythematosus

In Childhood-Onset Systemic Lupus Erythematosus (cSLE), poor medication adherence rates are very high. Interventions targeting this problem in cSLE are limited thus effective interventions are needed. The obje...

Authors: Onengiya Harry, Lori E. Crosby, Constance Mara, Tracy V. Ting, Jennifer L. Huggins and Avani C. Modi

COVID-19 and what pediatric rheumatologists should know: a review from a highly affected country

On March 11th, 2020 the World Health Organization declared COVID-19 a global pandemic. The infection, transmitted by 2019 novel coronavirus (2019-nCov), was first discovered in December 2019, in Wuhan, Hubei P...

Authors: Francesco Licciardi, Teresa Giani, Letizia Baldini, Ennio Giulio Favalli, Roberto Caporali and Rolando Cimaz

Treating juvenile idiopathic arthritis to target: what is the optimal target definition to reach all goals?

In 2018, an international Task Force formulated recommendations for treating Juvenile Idiopathic Arthritis (JIA) to target. The Task Force has not yet resolved three issues. The first issue is the lack of a si...

Authors: Casper G. Schoemaker, Joost F. Swart and Nico M. Wulffraat

Experiences, perspectives and expectations of adolescents with juvenile idiopathic arthritis regarding future work participation; a qualitative study

Having Juvenile idiopathic Arthritis (JIA) has widespread implications for a person’s life. Patients have to deal with recurring arthritis, characterized by pain often accompanied by a loss of energy. Since JI...

Authors: E. Charlotte van Gulik, Floris Verkuil, Anouk M. Barendregt, Dieneke Schonenberg-Meinema, Amara Nassar-Sheikh Rashid, Taco W. Kuijpers, J. Merlijn van den Berg and Jan L. Hoving

Familial chilblain lupus due to a novel mutation in TREX1 associated with Aicardi–Goutie’res syndrome

Familial chilblain lupus (FCL) is a rare, chronic form of cutaneous lupus erythematosus, which is characterized by painful bluish-red inflammatory cutaneous lesions in acral locations. Mutations in TREX1, SAMHD1 ...

Authors: Cuili Yi, Qiyuan Li and Jihong Xiao

Consensus treatment plans for periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome (PFAPA): a framework to evaluate treatment responses from the childhood arthritis and rheumatology research alliance (CARRA) PFAPA work group

Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome is the most common periodic fever syndrome in children. There is considerable heterogeneity in management strategies and...

Authors: Gil Amarilyo, Deborah Rothman, Kalpana Manthiram, Kathryn M. Edwards, Suzanne C. Li, Gary S. Marshall, Cagri Yildirim-Toruner, Kathleen Haines, Polly J. Ferguson, Geraldina Lionetti, Julie Cherian, Yongdong Zhao, Patricia DeLaMora, Grant Syverson, Simona Nativ, Marinka Twilt…

Spectrum of paediatric rheumatic disorders at a tertiary hospital in Tanzania

Paediatric rheumatic disorders are common in children and result in significant impairment in quality of life, morbidity and mortality. There is limited information on the burden of these disorders in lower in...

Authors: Francis F. Furia, Evance Godfrey, Naomi Mwamanenge and Peter Swai

Choroidal vascularity index as a biomarker of systemic inflammation in childhood Polyarteritis Nodosa and adenosine deaminase-2 deficiency

To assess EDI-OCT (enhanced depth imaging optical coherence tomography) of choroid for inflammatory signs in children with polyarteritis nodosa (PAN) and adenosine deaminase-2 deficiency (DADA-2).

Authors: Ata BAYTAROĞLU, Sibel KADAYIFÇILAR, Abdullah AĞIN, Özge DELİKTAŞ, Selcan DEMİR, Yelda BİLGİNER, Jale KARAKAYA, Seza ÖZEN and Bora ELDEM

A preliminary study of the child abuse and central sensitization in adolescent patients with chronic non-organic chest pain and an overlooked condition: juvenile fibromyalgia syndrome

Only a small percentage of pediatric chest pain is of cardiac origin and the most common detected cause is musculoskeletal. Among musculoskeletal causes, acute chest pain is better described, with the causes o...

Authors: Basak Mansiz-Kaplan, F. Figen Ayhan, Mihriban Cagli, Fatih Atik and İbrahim Ece

Inpatient mortality in transition-aged youth with rheumatic disease: an analysis of the National Inpatient Sample

Transition from pediatric to adult care is a vulnerable time for youth with chronic diseases. In youth with rheumatic disease, studies show high rates of loss to follow up and increased disease activity. Howev...

Authors: Paul T. Jensen, Keumseok Koh, Rebecca E. Cash, Stacy P. Ardoin and Ayaz Hyder

Importance of pediatric rheumatologists and transitional care for juvenile idiopathic arthritis-associated uveitis: a retrospective series of 9 cases

Juvenile idiopathic arthritis-associated uveitis (JIA-U) is a serious condition associated with the risk of blindness. However, pediatric rheumatologists rarely encounter cases of blindness, because most patie...

Authors: Susumu Yamazaki, Asami Shimbo, Yuko Akutsu, Hiroshi Takase, Tomohiro Morio and Masaaki Mori

Assessment of traditional and non-traditional risk factors for premature atherosclerosis in children with juvenile dermatomyositis and pediatric controls

Children with juvenile dermatomyositis (JDM), the most common inflammatory myopathy of childhood, may be at increased risk of premature atherosclerosis given a host of traditional and non-traditional risk fact...

Authors: Dawn M. Wahezi, Emily J. Liebling, Jaeun Choi, Marija Dionizovik-Dimanovski, Qi Gao and Jillian Parekh

A case of rectal ulcers during aspirin therapy in acute Kawasaki disease

Kawasaki disease (KD) is an acute febrile multisystem vasculitis and has been recognized to be one of the most common causes of acquired heart disease in children. Although gastrointestinal symptoms including ...

Authors: Yong Han, Chenmin Hu and Yanping Yu

The elevated serum levels of calcineurin and nuclear factor of activated T-cells 1 in children with Kawasaki disease

The calcineurin and nuclear factor of activated T-cells (CaN-NFAT) signaling pathway had been found to be associated with Kawasaki disease (KD) susceptibility and coronary artery aneurysm formation as a contri...

Authors: Yameng Sun, Jingjing Liu, Zhimin Geng, Yijing Tao, Fenglei Zheng, Ying Wang, Songling Fu, Wei Wang, Chunhong Xie, Yiying Zhang and Fangqi Gong

Patient factors associated with waiting time to pediatric rheumatologist consultation for patients with juvenile idiopathic arthritis

Early diagnosis and treatment of Juvenile Idiopathic Arthritis (JIA) is essential to optimize outcomes. Wait times (WTs) to consultation with a pediatric rheumatologist consultation is a Canadian quality measu...

Authors: Claire E. H. Barber, Cheryl Barnabe, Susanne Benseler, Ricky Chin, Nicole Johnson, Nadia Luca, Paivi Miettunen, Marinka Twilt, Dwaraka Veeramreddy, Natalie J. Shiff and Heinrike Schmeling

Factors impacting referral of JIA patients to a tertiary level pediatric rheumatology center in North India: a retrospective cohort study

JIA studies demonstrate that there is a “window of opportunity” early in the disease course during which appropriate management improves outcomes. No data is available regarding patients’ pathway, before first...

Authors: Manjari Agarwal, Caroline Freychet, Sumidha Jain, Abhay Shivpuri, Anju Singh, Veronique Dinand and Sujata Sawhney

Expert panel consensus recommendations for diagnosis and treatment of secondary osteoporosis in children

Osteoporosis incidence in children is increasing due to the increased survival rate of patients suffering from chronic diseases and the increased use of drugs that can damage bones.

Authors: Rocío Galindo-Zavala, Rosa Bou-Torrent, Berta Magallares-López, Concepción Mir-Perelló, Natalia Palmou-Fontana, Belén Sevilla-Pérez, Marta Medrano-San Ildefonso, Mª. Isabel González-Fernández, Almudena Román-Pascual, Paula Alcañiz-Rodríguez, Juan Carlos Nieto-Gonzalez, Mireia López-Corbeto and Jenaro Graña-Gil

Maintenance of antibody response to diphtheria/tetanus vaccine in patients aged 2–5 years with polyarticular-course juvenile idiopathic arthritis receiving subcutaneous abatacept

Patients with polyarticular-course juvenile idiopathic arthritis (pJIA), receiving disease-modifying anti-rheumatic drugs with immunosuppressive effects, may be at increased risk of vaccine-preventable infecti...

Authors: Hermine I. Brunner, Nikolay Tzaribachev, Gabriel Vega Cornejo, Rik Joos, Elisabeth Gervais, Rolando Cimaz, Inmaculada Calvo Penadés, Rubén Cuttica, Thomas Lutz, Pierre Quartier, Yash Gandhi, Marleen Nys, Robert Wong, Alberto Martini, Daniel J. Lovell and Nicolino Ruperto

Correction to: Biomarkers associating endothelial dysregulation in pediatric-onset systemic lupus erythematous

Following publication of the original article [1], we have been notified that the colour representation of the graph is not correct in Figure 6 legend.

Authors: Wan-Fang Lee, Chao-Yi Wu, Huang-Yu Yang, Wen-I Lee, Li-Chen Chen, Liang-Shiou Ou and Jing-Long Huang

Consensus protocols for the diagnosis and management of the hereditary autoinflammatory syndromes CAPS, TRAPS and MKD/HIDS: a German PRO-KIND initiative

Rare autoinflammatory diseases (AIDs) including Cryopyrin-Associated Periodic Syndrome (CAPS), Tumor Necrosis Receptor-Associated Periodic Syndrome (TRAPS) and Mevalonate Kinase Deficiency Syndrome (MKD)/ Hype...

Authors: Sandra Hansmann, Elke Lainka, Gerd Horneff, Dirk Holzinger, Nikolaus Rieber, Annette F. Jansson, Angela Rösen-Wolff, Gabi Erbis, Martina Prelog, Juergen Brunner, Susanne M. Benseler and Jasmin B. Kuemmerle-Deschner

Correction to: Pain, functional disability, and their Association in Juvenile Fibromyalgia Compared to other pediatric rheumatic diseases

Following publication of the original article [1], we have been notified that the corresponding author’s given name is spelled incorrectly. The given name, thus, should be as follows:

Authors: Mark Connelly and Jennifer E. Weiss

Adolescent Sjogren’s syndrome presenting as psychosis: a case series

Neurological involvement has been reported in up to 80% of adults with Primary Sjogren’s syndrome (pSS) with psychiatric abnormalities including anxiety, depression, and cognitive dysfunction being common. Psy...

Authors: Erin K. Hammett, Cristina Fernandez-Carbonell, Courtney Crayne, Alexis Boneparth, Randy Q. Cron and Suhas M. Radhakrishna

Correction to: Proposal for a definition for response to treatment, inactive disease and damage for JIA associated uveitis based on the validation of a uveitis related JIA outcome measures from the Multinational Interdisciplinary Working Group for Uveitis in Childhood (MIWGUC)

Following publication of the original article [1], we have been notified that the author Joan Calzada should not have been included to the team of authors. The authors’ team, thus, should be as follows:

Authors: Ivan Foeldvari, Jens Klotsche, Gabriele Simonini, Clive Edelsten, Sheila T. Angeles-Han, Regitze Bangsgaard, Joke de Boer, Gabriele Brumm, Rosa Bou Torrent, Tamas Constantin, Cinzia DeLibero, Jesus Diaz, Valeria Maria Gerloni, Margarida Guedes, Arnd Heiligenhaus, Kaisu Kotaniemi…

Children’s fear of needle injections: a qualitative study of training sessions for children with rheumatic diseases before home administration

Treatment of rheumatic diseases in children often includes long-term needle injections, which represent a risk for refusing medication based on potential needle-fear. How nurses manage children’s fear and pain...

Authors: Kari Sørensen, Helge Skirbekk, Gunnvald Kvarstein and Hilde Wøien

Pharmacological conditioning for juvenile idiopathic arthritis: a potential solution to reduce methotrexate intolerance

Methotrexate (MTX) therapy has proven to be a successful and safe treatment for Juvenile Idiopathic Arthritis (JIA). Despite the high efficacy rates of MTX, treatment outcomes are often complicated by burdenso...

Authors: Rosanne M. Smits, Dieuwke S. Veldhuijzen, Henriet van Middendorp, Petra C. E. Hissink Muller, Wineke Armbrust, Elizabeth Legger, Nico M. Wulffraat and Andrea W. M. Evers

Correction to: Physical activity and health-related quality of life in chronic non-bacterial osteomyelitis

Following publication of the original article [1], we have been notified that the authors’ first names and last names are presented in wrong order. The presentation of names, thus, should be as follows:

Authors: Julia Nentwich, Katharina Ruf, Hermann Girschick, Annette Holl-Wieden, Henner Morbach, Helge Hebestreit and Christine Hofmann

Quantitative analysis of facial asymmetry based on three-dimensional photography: a valuable indicator for asymmetrical temporomandibular joint affection in juvenile idiopathic arthritis patients?

Juvenile idiopathic arthritis (JIA) can cause osseous deformity in the temporomandibular joint (TMJ) and may impair mandibular growth. This study aimed to evaluate whether facial asymmetry determined clinicall...

Authors: Joëlle M. Bernini, Christian J. Kellenberger, Martina Eichenberger, Theodore Eliades, Spyridon N. Papageorgiou and Raphael Patcas

Pregnancy outcomes and perinatal complications of Asian mothers with juvenile idiopathic arthritis – a case-control registry study

In order to provide juvenile idiopathic arthritis (JIA) patients with better pre-conceptional and prenatal counselling, we investigated the obstetrical and neonatal outcomes among women with Asian descent.

Authors: Shang Jun Zhang-Jian, Huang-Yu Yang, Meng-Jun Chiu, I-Jun Chou, Chang-Fu Kuo, Jing-Long Huang, Kuo-Wei Yeh and Chao-Yi Wu

Correction to: Demographic, clinical, and treatment characteristics of the juvenile primary fibromyalgia syndrome cohort enrolled in the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry

Following publication of the original article [1], we have been notified that the corresponding author’s given name is spelled incorrectly.

Authors: Jennifer E. Weiss, Kenneth N. Schikler, Alexis D. Boneparth and Mark Connelly

The use of S100 proteins testing in juvenile idiopathic arthritis and autoinflammatory diseases in a pediatric clinical setting: a retrospective analysis

Serum phagocyte-derived alarmins S100A8/9 and S100A12 are considered useful for the assessment of inflammatory diseases. Our study evaluated the use of S100 proteins in a pediatric clinical setting for estimat...

Authors: Najla Aljaberi, Elena Tronconi, Grant Schulert, Alexei A. Grom, Daniel J. Lovell, Jennifer L. Huggins, Michael Henrickson and Hermine I. Brunner

Patients with enthesitis related arthritis show similar monocyte function pattern as seen in adult axial spondyloarthropathy

Axial SpA and Enthesitis related arthritis (ERA) patients show strong HLA-B27 association, gut dysbiosis, high toll like receptor (TLR)2 and 4 expression on monocytes, pro-inflammatory cytokine production and ...

Authors: Shruti Bhattacharya, Ramnath Misra and Amita Aggarwal

Patient and physician discordance of global disease assessment in juvenile dermatomyositis: findings from the Childhood Arthritis & Rheumatology Research Alliance Legacy Registry

Global disease activity scores (gVAS) capture patient or family (PF) and physician (MD) assessments of disease. This study sought to measure discordance between PF and MD global activity scores in juvenile der...

Authors: Heather Tory, David Zurakowski and Susan Kim

Pediatric chronic nonbacterial osteomyelitis of the mandible: Seattle Children’s hospital 22-patient experience

Studies evaluating treatment responses for chronic nonbacterial osteomyelitis (CNO) are lacking. We aimed to measure and compare response rates of medical treatments, time to response of medical treatments amo...

Authors: Austin Gaal, Matthew L. Basiaga, Yongdong Zhao and Mark Egbert

Development and validation of the CAREGIVERS questionnaire: multi-assessing the impact of juvenile idiopathic arthritis on caregivers

The primary caregiver is an important person in the life of patients with JIA. Their reactions depend on social, emotional and economic factors that affect the therapeutic alliance. Some generic instruments ha...

Authors: Marcia Daniela Torres-Made, Ingris Peláez-Ballestas, Fernando García-Rodríguez, Ana Victoria Villarreal-Treviño, Brenda de Jesús Fortuna-Reyna, Manuel Enrique de la O-Cavazos and Nadina Eugenia Rubio-Pérez

Tocilizumab modifies clinical and laboratory features of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis

This study aimed to determine the influence of tocilizumab (TCZ) in modifying the clinical and laboratory features of macrophage activation syndrome (MAS) complicating systemic juvenile idiopathic arthritis (s...

Authors: Masaki Shimizu, Mao Mizuta, Nami Okamoto, Takahiro Yasumi, Naomi Iwata, Hiroaki Umebayashi, Yuka Okura, Noriko Kinjo, Tomohiro Kubota, Yasuo Nakagishi, Kenichi Nishimura, Mariko Mohri, Masato Yashiro, Junko Yasumura, Hiroyuki Wakiguchi and Masaaki Mori

Persistent osteoarticular pain in children: early clinical and laboratory findings suggestive of acute lymphoblastic leukemia (a multicenter case-control study of 147 patients)

The aim of this study was to identify early clinical and laboratory features that distinguish acute lymphoblastic leukemia (ALL) from juvenile idiopathic arthritis (JIA) in children presenting with persistent ...

Authors: Mathilde Louvigné, Josué Rakotonjanahary, Laurence Goumy, Aude Tavenard, Jean-François Brasme, Fanny Rialland, André Baruchel, Marie-Françoise Auclerc, Véronique Despert, Marie Desgranges, Sylvie Jean, Albert Faye, Ulrich Meinzer, Mathie Lorrot, Chantal Job-Deslandre, Brigitte Bader-Meunier…

Chronic idiopathic musculoskeletal pain in youth: a qualitative study

Chronic musculoskeletal pain (MSP) is frequent in adolescents and has major medical and social consequences. In many cases, when no cause has been clearly established, this pain may be considered to be chronic...

Authors: Hervé Lefèvre, Alexandra Loisel, Brigitte Bader Meunier, Chantal Deslandre, Noémie Lemoine, Marie Rose Moro, Pierre Quartier and Jonathan Lachal

Patient and caregiver engagement in research: factors that influence co-enrollment in research

Recruitment of pediatric participants in studies is difficult due to the vulnerability of this population and the scarcity of certain conditions. Co-enrolling in multiple studies is a strategy that may help ov...

Authors: Leanne K. Elliott, Herman Bami, Maxwell J. Gelkopf, Ryan C. Yee, Brian M. Feldman and Y. Ingrid Goh

Is fibrodysplasia ossificans progressiva an interleukin-1 driven auto-inflammatory syndrome?

Fibrodysplasia ossificans progressiva (FOP) is the most catastrophic form of heterotopic ossification, due to ongoing intracellular signaling through the bone morphogenic protein pathway. The paroxysmal appear...

Authors: Ruby Haviv, Veronica Moshe, Fabrizio De Benedetti, Giusi Prencipe, Noa Rabinowicz and Yosef Uziel

Orofacial pain in juvenile idiopathic arthritis is associated with stress as well as psychosocial and functional limitations

The aim of this study was to investigate relations between psychosocial factors, signs and symptoms of orofacial pain and jaw dysfunction in patients with juvenile idiopathic arthritis (JIA).

Authors: Alexandra Dimitrijevic Carlsson, Kerstin Wahlund, Erik Kindgren, Thomas Skogh, Carin Starkhammar Johansson and Per Alstergren

Arthritis in children with LRBA deficiency – case report and literature review

Lipopolysaccharide (LPS)-responsive and beige like anchor (LRBA) deficiency is categorized as a subtype of common variable immune deficiency (CVID). A growing number of case reports and cohorts reveal a broad ...

Authors: Rotem Semo Oz and Melissa S. Tesher

Oral health and plaque microbial profile in juvenile idiopathic arthritis

The oral microbiota has been implicated in the pathogenesis of rheumatoid arthritis through activation of mucosal immunity. This study tested for associations between oral health, microbial communities and juv...

Authors: Sriharsha Grevich, Peggy Lee, Brian Leroux, Sarah Ringold, Richard Darveau, Gretchen Henstorf, Joel Berg, Amy Kim, Elizabeth Velan, Joseph Kelly, Camille Baltuck, Anne Reeves, Hannah Leahey, Kyle Hager, Mitchell Brittnacher, Hillary Hayden…

Health-related quality of life during early aggressive treatment in patients with polyarticular juvenile idiopathic arthritis: results from randomized controlled trial

Juvenile Idiopathic Arthritis (JIA) may cause significant impairment in health-related quality of life (HrQoL), despite effective therapies. The aim of this study was to assess HrQoL during first-year treatmen...

Authors: Maarit Tarkiainen, Pirjo Tynjälä, Paula Vähäsalo, Liisa Kröger, Kristiina Aalto and Pekka Lahdenne

Proceedings of the 2019 Childhood Arthritis and Rheumatology Research Alliance (CARRA) Annual Scientific Meeting

Authors: