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  1. Currently, the criteria used to classify patients with SJIA are different from those used for AOSD. However, it has been recognized that the existing terms are too narrow, subdividing the Still’s population un...

    Authors: Peter A. Nigrovic, Fabrizio de Benedetti, Yukiko Kimura, Daniel J. Lovell and Sebastiaan J. Vastert
    Citation: Pediatric Rheumatology 2024 21(Suppl 1):114

    This article is part of a Supplement: Volume 21 Supplement 1

  2. Although the introduction of the IL-1 and IL-6 inhibiting biologics in 2012 has revolutionized the treatment and markedly improved outcomes for many patients with SJIA, about 20% of these patients continue to ...

    Authors: Grant Schulert, Sebastiaan J. Vastert and Alexei A. Grom
    Citation: Pediatric Rheumatology 2024 21(Suppl 1):87

    This article is part of a Supplement: Volume 21 Supplement 1

  3. It has been increasingly recognized that there is a subset of patients with refractory systemic JIA, who have failed all available medications and may benefit from HSCT. The increasing experience with HSCT in ...

    Authors: Alexei A. Grom, Scott W. Canna, Rolla F. Abu-Arja, Rashmi Sinha, Luciana Peixoto, Elvira Cannizzaro, Shanmuganathan Chandrakasan, Kyla Driest, Rebecca Marsh, Bénédicte Neven, Karen Onel, Sampath Prahalad, Susan Prockop, Pierre Quartier, Johannes Roth, Grant Schulert…
    Citation: Pediatric Rheumatology 2024 21(Suppl 1):86

    This article is part of a Supplement: Volume 21 Supplement 1

  4. Since IL-18 has recently emerged as a biomarker associated with refractory disease course in SJIA, the focus of the discussion was the feasibility of the biomarker-driven drug development to SJIA. Overall, the...

    Authors: Scott W. Canna and Fabrizio De Benedetti
    Citation: Pediatric Rheumatology 2024 21(Suppl 1):79

    This article is part of a Supplement: Volume 21 Supplement 1

  5. Mevalonate kinase deficiency (MKD) and TNF receptor-associated periodic syndrome (TRAPS) are categorized as systemic autoinflammatory diseases (SAIDs), which are rare diseases characterized by early onset, sev...

    Authors: Yandie Li and Meiping Lu
    Citation: Pediatric Rheumatology 2024 22:11
  6. Studies on prevalence rates of mental comorbidities in patients with juvenile idiopathic arthritis (JIA) have reported varying results and provided limited information on related drugs. The purpose of this stu...

    Authors: Florian Milatz, Katinka Albrecht, Kirsten Minden, Ursula Marschall, Jens Klotsche and Johanna Callhoff
    Citation: Pediatric Rheumatology 2024 22:10
  7. STING-associated vasculopathy with onset in infancy (SAVI) is a rare type I interferonopathy caused by heterozygous variants in the STING gene. In SAVI, STING variants confer a gain-of-function which causes overa...

    Authors: Sophia Weidler, Sarah Koss, Christine Wolf, Nadja Lucas, Jürgen Brunner and Min Ae Lee-Kirsch
    Citation: Pediatric Rheumatology 2024 22:9
  8. Juvenile idiopathic recurrent parotitis (JIRP) in children is a condition characterized with recurrent episodes of idiopathic parotid gland inflammation. Since there are no definitive guidelines for diagnosis ...

    Authors: Farhad Salehzadeh, Rasol Molatefi, Ali Mardi and Negin Nahanmoghaddam
    Citation: Pediatric Rheumatology 2024 22:8
  9. The substantial morbidity and mortality associated with refractory systemic JIA underlies the need for new treatment approaches. However, progress in this area has been limited by the difficulty of enrolling t...

    Authors: Fabrizio de Benedetti, Alexei A. Grom and Hermine Brunner
    Citation: Pediatric Rheumatology 2024 21(Suppl 1):150

    This article is part of a Supplement: Volume 21 Supplement 1

  10. Juvenile idiopathic arthritis (JIA) is a prevalent childhood chronic arthritis, often persisting into adulthood. Effective transitional care becomes crucial as these patients transition from pediatric to adult...

    Authors: Betül Sözeri, Nihal Şahin, Ceyhun Açarı, Pinar Ozge Avar Aydın, Ozge Baba, Esra Bağlan, Sevcan Bakkaloğlu, Sibel Bakırcı, Yelda Bilginer, Burcu Yücel Bozkaya, Şengül Çağlayan, Mustafa Çakan, Figen Çakmak, Taner Coşkuner, Ferhat Demir, Fatma Gül Demirkan…
    Citation: Pediatric Rheumatology 2024 22:7
  11. Juvenile Idiopathic Arthritis (JIA) induces growth disturbances in affected joints. Fibroblast-like synoviocytes (FLS) play a crucial role in JIA pathogenesis. FLS overexpress bone morphogenetic protein 4 (BMP...

    Authors: Megan M. Simonds, Samuel T. Freer and Anne Marie C. Brescia
    Citation: Pediatric Rheumatology 2024 22:6
  12. In pediatric rheumatic diseases (PRD), adalimumab is dosed using fixed weight-based bands irrespective of methotrexate co-treatment, disease activity (DA) or other factors that might influence adalimumab pharm...

    Authors: Tatjana Welzel, Klervi Golhen, Andrew Atkinson, Verena Gotta, David Ternant, Jasmin B. Kuemmerle-Deschner, Christine Michler, Gilbert Koch, Johannes N. van den Anker, Marc Pfister and Andreas Woerner
    Citation: Pediatric Rheumatology 2024 22:5
  13. A rare case of coronary artery involvement in a child with Systemic Juvenile Idiopathic Arthritis (sJIA) complicated by Macrophage Activation Syndrome (MAS) is reported. The patient initially received an inacc...

    Authors: Lian Zhang, Yanwen Wei, Ningjing Zeng, Lianyu Wang, Xinying Chen, Jinghua Yang and Xiaolan Xiao
    Citation: Pediatric Rheumatology 2024 22:4
  14. Patients with rheumatological diseases are at high risk of developing irreversible fibrotic changes, both articular and extra-articular, as a result of tissue damage caused by the chronic phase of persistent i...

    Authors: Olga Pavlova, Natalia Shevchenko, Sergey Pavlov, Tetiana Holovko and Liudmyla Bogmat
    Citation: Pediatric Rheumatology 2024 22:3
  15. Juvenile Dermatomyositis (JDM) is a rare autoimmune disorder that primarily affects muscles and skin. One of the severe complications associated with JDM is calcinosis, and treating this condition presents sig...

    Authors: Reza Shiari, Mitra Khalili, Vahide Zeinali, Niloufar Shashaani, Mohammad Samami and Foroughossadat Hosseini Moghaddamemami
    Citation: Pediatric Rheumatology 2024 22:2
  16. Common severe back pain due to disc herniation is rare in the paediatric population which involves children under eighteen years of age. Paediatric lumbar disc herniation (LDH) cannot be considered the same di...

    Authors: Wendlassida Joelle Stéphanie Tiendrebeogo/Zabsonre, Denlewende Sylvain Zabsonre, Fulgence Kabore, Abdoulaye Sanou, Yakouba Haro, Inoussa Zoungrana and Dieu-Donné Ouedraogo
    Citation: Pediatric Rheumatology 2024 22:1
  17. With chronic diseases, the responsibility for care transfers to adult clinics at some point. Juvenile idiopathic arthritis (JIA) is the most common persistent rheumatic condition in children. A successful tran...

    Authors: Katriina Mikola, Katariina Rebane, Hannu Kautiainen and Kristiina Aalto
    Citation: Pediatric Rheumatology 2023 21:149

    The Correction to this article has been published in Pediatric Rheumatology 2024 22:14

  18. Adalimumab is currently considered the most efficacious anti-TNFα agent for childhood noninfectious uveitis (NIU). The objective of this study was to define a therapeutic range for adalimumab trough levels in...

    Authors: Jo L. Dehoorne, Helena Groth, Emma Carlé, Ilse De Schrijver, Celine Sys, Patricia Delbeke, Elke O. Kreps, Thomas Renson and Carolien Bonroy
    Citation: Pediatric Rheumatology 2023 21:148
  19. Septic arthritis is an important differential diagnosis of hip joint pain. Joint aspiration analysis is a necessary diagnostic measure for septic arthritis. In order to reduce the need for joint aspiration, we...

    Authors: Seyed Ali Alamdaran, Mohadeseh Taheri-nezhad, Ahmad Nouri, Farzaneh Khoroushi, Mohammad Hasan Aalami, Abdoreza Malek, Arezou Mohtasham and Mohamadreza Alizadeh
    Citation: Pediatric Rheumatology 2023 21:146
  20. Much has been written and spoken about telemedicine since about two decades including an article in this journal at the start of the pandemic. It took a global catastrophe to enforce its usage across the world...

    Authors: Raju Khubchandani, Tadej Avčin and Angelo Ravelli
    Citation: Pediatric Rheumatology 2023 21:145
  21. Due to the paucity of paediatric rheumatologists in Kenya, it is paramount that we explore strategies to bridge clinical care gaps for paediatric rheumatology patients in order to promote early diagnosis, prom...

    Authors: Angela Migowa, Sasha Bernatsky, Anthony K. Ngugi, Helen E. Foster, Peterrock Muriuki, Roselyter M. Riang’a and Stanley Luchters
    Citation: Pediatric Rheumatology 2023 21:144
  22. Juvenile idiopathic arthritis (JIA) is a broad term used to describe arthritis of unknown origin. JIA commonly persists into adulthood, often causing substantial morbidity such as restricted joint function, wh...

    Authors: Yun Liu and Xuemei Tang
    Citation: Pediatric Rheumatology 2023 21:143
  23. The treatment of children with multisystem inflammatory syndrome in children (MIS-C) related to SARS-CoV-2 infection involves immunomodulatory therapies such as IVIG and steroids. Anakinra, an interleukin-1 re...

    Authors: Esra B. Akkoyun, Zachary Most, Harita Katragadda, Andrew Yu, Lorien Nassi, Nicole Oakman, Sarah Ginsburg and Mia Maamari
    Citation: Pediatric Rheumatology 2023 21:141
  24. There is no clear data on the optimal duration of treatment with anti-interleukin-1 drugs in colchicine-resistant familial Mediterranean fever patients, as well as on the dose interval. This study aimed to ass...

    Authors: Gülşah Kavrul Kayaalp, Şengül Çağlayan, Fatma Gül Demirkan, Vafa Guliyeva, Gülçin Otar Yener, Kübra Öztürk, Ferhat Demir, Semanur Özdel, Mustafa Çakan, Hafize Emine Sönmez, Betül Sözeri and Nuray Aktay Ayaz
    Citation: Pediatric Rheumatology 2023 21:140
  25. Patients with systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still’s disease (AOSD) have been under-represented in studies about safety of the COVID-19 immunization. We aimed to inquire about th...

    Authors: Mariana Correia Marques, Subrata Paul, Carol Lake, Ly-Lan Bergeron, Rashmi Sinha, Luciana Peixoto, Marinka Twilt and Michael J. Ombrello
    Citation: Pediatric Rheumatology 2023 21:139
  26. Juvenile Dermatomyositis (JDM) is a rare autoimmune disease characterized by skin and muscle inflammation. The loss of nail fold capillary end row loops (ERL) is evidence of small vessel involvement in JDM. Th...

    Authors: Amer Khojah, Gabrielle Morgan, Marisa S. Klein-Gitelman and Lauren M. Pachman
    Citation: Pediatric Rheumatology 2023 21:137
  27. Background: Rheumatic patients have a higher frequency of tuberculosis(TB) than the general population. This study aimed to describe children and adolescents with TB and rheumatic diseases(RD) who were being t...

    Authors: Lenita de Melo Lima, Adriana Rodrigues Fonseca, Clemax Couto Sant’Anna, Ana Alice Amaral Ibiapina Parente, Rafaela Baroni Aurilio and Maria de Fátima Bazhuni Pombo Sant’Anna
    Citation: Pediatric Rheumatology 2023 21:136
  28. It has been reported that the complete heart block (CHB) in neonatal lupus (NL) cannot be reversed. This study reported a case of NL-CHB that was reversed by transcutaneous pacing and repeated plasmapheresis.

    Authors: Yanfei Liu, Wanwei Li, Kun Zhou and Zhangxue Hu
    Citation: Pediatric Rheumatology 2023 21:135
  29. Juvenile Idiopathic Arthritis (JIA) is the most common form of childhood inflammatory arthritis. The disease burden of JIA is substantial as patients require specialized medical practitioners for diagnosis and...

    Authors: Niloofar Gheshlaghi, Megan Thomas, Natasha Trehan, Mark Harrison and Mary A. De Vera
    Citation: Pediatric Rheumatology 2023 21:134
  30. Pediatric musculoskeletal disorders account for 10% of first-line consultations in Tunisia. Referral delay and deficiencies in musculoskeletal screening raise a challenge to the early diagnosis and management ...

    Authors: Lassoued Ferjani Hanene, Narjess Amdouni, Rabhi Emna, Sahli Hela, Ben Abdelgheni Kaouther, Ben Nessib Dorra, Kaffel Dhia, Maatallah Kaouther and Hamdi Wafa
    Citation: Pediatric Rheumatology 2023 21:133
  31. Gain-of-function mutations in STING1 (also known as TMEM173) which result in constitutive activation of STING, have been reported to cause STING-associated vasculopathy with onset in infancy (SAVI). Although a wi...

    Authors: Jianqiang Wu, Qing Zhou, Hua Zhou and Meiping Lu
    Citation: Pediatric Rheumatology 2023 21:131
  32. Systemic lupus erythematosus is an autoimmune disease that involves multiple organ systems. One of its major complications, lupus nephritis (LN), is associated with a high mortality rate, and children-onset LN...

    Authors: Shi-jie Li, Dan-dan Ruan, Wei-zhen Wu, Min Wu, Qiu-yan Wu, Han-lu Wang, Yuan-yuan Ji, Yan-ping Zhang, Xin-fu Lin, Zhu-ting Fang, Li-sheng Liao, Jie-wei Luo, Mei-zhu Gao and Jia-bin Wu
    Citation: Pediatric Rheumatology 2023 21:130
  33. The linkage between prolactin (PRL) and systemic lupus erythematosus (SLE) is still vague. Determination of serum levels of prolactin to reveal its role in patients with SLE is the aim of the study.

    Authors: Hend Mehawed Soliman, Balsam Sherif Fahmy, Moataz Gamal Ali and Eman Shafik Shafie
    Citation: Pediatric Rheumatology 2023 21:128
  34. Insights into the immunological role of the gastrointestinal tract in autoimmune conditions have led to the investigation of diet as a potential adjunctive treatment option for juvenile idiopathic arthritis (J...

    Authors: Naima Hagström, Elin Lövestam, Afsaneh Koochek and Lillemor Berntson
    Citation: Pediatric Rheumatology 2023 21:127
  35. Connective tissue nevi (CTN) are congenital hamartomas caused by excessive proliferation of dermis components. In children, CTN can mimic juvenile localized scleroderma (JLS), an immune mediated skin disorder ...

    Authors: F. Tirelli, C. Giraudo, M. Soliani, F. Calabrese, G. Martini, P. Gisondi, A. Meneghel and Francesco Zulian
    Citation: Pediatric Rheumatology 2023 21:125
  36. Monogenic autoinflammatory diseases (AIDs) are rare inflammatory diseases caused by genetic variants. The pathogenesis is complex and treatment options are limited. This study aimed to describe the safety and ...

    Authors: Caihui Zhang, Zhongxun Yu, Sihao Gao, Mingsheng Ma, Lijuan Gou, Changyan Wang, Lin Wang, Ji Li, Linqing Zhong, Yu Zhou, Wei Wang and Hongmei Song
    Citation: Pediatric Rheumatology 2023 21:124
  37. Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that is associated with multiple organ involvement and leads to significant morbidity and mortality. One of the important environmental facto...

    Authors: Porntipa Suebsarakam and Dara Mairiang
    Citation: Pediatric Rheumatology 2023 21:123
  38. Hypermobile Ehlers-Danlos syndrome (hEDS) is characterized by joint and skin laxity, and often accompanied by chronic pain, dysautonomia, increased distress and, functional limitations. The journey to accurate...

    Authors: Estée C.H. Feldman, Kendra J. Homan, Sara E. Williams, Tracy V. Ting, Kenneth R. Goldschneider and Susmita Kashikar-Zuck
    Citation: Pediatric Rheumatology 2023 21:121
  39. Pediatric rheumatology faces a looming supply-demand crisis. While strategies have been proposed to address the supply shortfall, investigation into the increased demand for pediatric rheumatic care has been l...

    Authors: Daniel D Reiff, John M Bridges, Eileen C Rife, Victoria L Gennaro, Linda McAllister, Annelle Reed, Carolyn Smith, Bethany Walker, Peter Weiser, Emily A Smitherman, Matthew L Stoll, Melissa L Mannion and Randy Q Cron
    Citation: Pediatric Rheumatology 2023 21:120
  40. Sjögren’s syndrome (SS) is a rare disease with unclear diagnostic criteria among the children and adolescents. The purpose of this study is to describe the clinical features of pediatric Sjögren’s syndrome and...

    Authors: Ling Hou, Ningning Wang, Chengguang Zhao, Xiuli Wang and Yue Du
    Citation: Pediatric Rheumatology 2023 21:119
  41. We lack a reliable indicator of disease activity in Juvenile Dermatomyositis (JDM), a rare disease. The goal of this study is to identify the association of nailfold capillary End Row Loop (ERL) loss with dise...

    Authors: Lauren M. Pachman, Gabrielle Morgan, Marisa S. Klein-Gitelman, Najah Ahsan and Amer Khojah
    Citation: Pediatric Rheumatology 2023 21:118

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