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  1. Content type: Research article

    To understand the relationship between regulatory B cells (Bregs) and juvenile idiopathic arthritis (JIA), we analyzed the percentages of Bregs and their function in peripheral blood (PB) and synovial fluid (S...

    Authors: Qianzi Zhao and Lawrence K. Jung

    Citation: Pediatric Rheumatology 2018 16:44

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  2. Content type: Research article

    Juvenile idiopathic arthritis (JIA) is an inflammatory arthritis of unknown etiology, which lasts for greater than 6 weeks with onset before 16 years of age. JIA is the most common chronic rheumatic disease in...

    Authors: Daniel J. Lovell, Jason A. Dare, Megan Francis-Sedlak, Julie Ball, Brian D. LaMoreaux, Emily Von Scheven, Adam Reinhardt, Rita Jerath, Oral Alpan, Ramesh Gupta, Donald Goldsmith, Andrew Zeft, Henry Naddaf, Beth Gottlieb, Lawrence Jung and Robert J. Holt

    Citation: Pediatric Rheumatology 2018 16:41

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  3. Content type: Research article

    Juvenile dermatomyositis (JDM) is the most common inflammatory myopathy in childhood and a major cause of morbidity among children with pediatric rheumatic diseases. The management of JDM is very heterogeneous...

    Authors: Claas H. Hinze, Prasad T. Oommen, Frank Dressler, Andreas Urban, Frank Weller-Heinemann, Fabian Speth, Elke Lainka, Jürgen Brunner, Heike Fesq, Dirk Foell, Wolfgang Müller-Felber, Ulrich Neudorf, Christoph Rietschel, Tobias Schwarz, Ulrike Schara and Johannes-Peter Haas

    Citation: Pediatric Rheumatology 2018 16:40

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  4. Content type: Research article

    Inflammatory effector T cells trigger inflammation despite increased numbers of Treg cells in the synovial joint of patients suffering from juvenile idiopathic arthritis (JIA). The cAMP response element (CREM)...

    Authors: Kim Ohl, Helge Nickel, Halima Moncrieffe, Patricia Klemm, Anja Scheufen, Dirk Föll, Viktor Wixler, Angela Schippers, Norbert Wagner, Lucy R. Wedderburn and Klaus Tenbrock

    Citation: Pediatric Rheumatology 2018 16:39

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  5. Content type: Research article

    Juvenile Dermatomyositis (JDM) is a rare pediatric autoimmune disease with broad variations of the individual course. Data on the optimal management are mostly lacking. Currently treatment decisions are often ...

    Authors: Claas H. Hinze, Fabian Speth, Prasad T. Oommen and Johannes-Peter Haas

    Citation: Pediatric Rheumatology 2018 16:38

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  6. Content type: Short Report

    To assess reliability of the two indexes of Localized Scleroderma Cutaneous Assessment Tool (LoSCAT), the modified Localized Scleroderma Skin Severity Index (mLoSSI) and the Localized Scleroderma Skin Damage I...

    Authors: Anna Agazzi, Gloria Fadanelli, Fabio Vittadello, Francesco Zulian and Giorgia Martini

    Citation: Pediatric Rheumatology 2018 16:37

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  7. Content type: Research article

    Bisphosphonates are recommended for use as first-line therapy for the prevention and treatment of glucocorticoid-induced osteoporosis in adults. However, the appropriate usage of bisphosphonates for the preven...

    Authors: Yuzaburo Inoue, Kanako Mitsunaga, Takeshi Yamamoto, Koki Chiba, Fumiya Yamaide, Taiji Nakano, Yoshinori Morita, Akiko Yamaide, Shuichi Suzuki, Takayasu Arima, Ken-ichi Yamaguchi, Minako Tomiita, Naoki Shimojo and Yoichi Kohno

    Citation: Pediatric Rheumatology 2018 16:36

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  8. Content type: Research article

    Involving people of all ages in health research is now widely advocated. To date, no studies have explored whether and how young people with chronic rheumatic conditions want to be involved in influencing heal...

    Authors: Suzanne Parsons, Wendy Thomson, Katharine Cresswell, Bella Starling and Janet E. McDonagh

    Citation: Pediatric Rheumatology 2018 16:35

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  9. Content type: Review

    Vitamin D has been implicated in the pathogenesis of autoimmune diseases. While the roles of vitamin D in other autoimmune diseases have been investigated, less is known about the role of vitamin D in chronic ...

    Authors: Sarah L. Finch, Alan M. Rosenberg and Hassan Vatanparast

    Citation: Pediatric Rheumatology 2018 16:34

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  10. Content type: Research article

    The pathogenesis of Kawasaki disease are still not well understood. It was designed to investigate the relationship between adipokines including chemerin, omentin-1, adiponectin and acute Kawasaki disease.

    Authors: Xin-yan Zhang, Ting-ting Yang, Xiu-fen Hu, Yu Wen, Feng Fang and Hui-ling Lu

    Citation: Pediatric Rheumatology 2018 16:33

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  11. Content type: Research article

    To compare final height to mid-parental target height among adults with childhood-onset systemic lupus erythematosus (cSLE) versus adult-onset SLE (aSLE), and to evaluate the impact of age at SLE onset on fina...

    Authors: Merav Heshin-Bekenstein, Liat Perl, Aimee O. Hersh, Emily von Scheven, Ed Yelin, Laura Trupin, Jinoos Yazdany and Erica F. Lawson

    Citation: Pediatric Rheumatology 2018 16:30

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  12. Content type: Correction

    Following publication of the original article [1], the authors reported that the names of two institutional authors – EUROFEVER and the Paediatric Rheumatology International Trials Organisation (PRINTO) – had ...

    Authors: Romina Gallizzi, Caterina Pidone, Luca Cantarini, Martina Finetti, Marco Cattalini, Giovanni Filocamo, Antonella Insalaco, Donato Rigante, Rita Consolini, Maria Cristina Maggio, Adele Civino, Silvana Martino, Alma Nunzia Olivieri, Giovanna Fabio, Serena Pastore, Angela Mauro…

    Citation: Pediatric Rheumatology 2018 16:29

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    The original article was published in Pediatric Rheumatology 2017 15:84

  13. Content type: Research article

    A standardized set of quality measures for juvenile idiopathic inflammatory myopathies (JIIM) is not in use. Discordance has been shown between the importance ascribed to quality measures between patients and ...

    Authors: Heather O. Tory, Ruy Carrasco, Thomas Griffin, Adam M. Huber, Philip Kahn, Angela Byun Robinson, David Zurakowski and Susan Kim

    Citation: Pediatric Rheumatology 2018 16:28

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  14. Content type: Research article

    Diagnosis of Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) is currently based on a set of criteria proposed in 1999 modified from Marshall’s criteria. Nevertheless no validated...

    Authors: Federica Vanoni, Silvia Federici, Jordi Antón, Karyl S. Barron, Paul Brogan, Fabrizio De Benedetti, Fatma Dedeoglu, Erkan Demirkaya, Veronique Hentgen, Tilmann Kallinich, Ronald Laxer, Ricardo Russo, Natasa Toplak, Yosef Uziel, Alberto Martini, Nicolino Ruperto…

    Citation: Pediatric Rheumatology 2018 16:27

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  15. Content type: Research article

    Pregnant women with systemic lupus erythematosus (SLE) have increased risk of adverse outcomes including disease flare, spontaneous abortion, preeclampsia/eclampsia, premature birth and maternal death. However...

    Authors: Nicole Ling, Erica Lawson and Emily von Scheven

    Citation: Pediatric Rheumatology 2018 16:26

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  16. Content type: Research article

    The recurrence rate of Henoch-Schönlein purpura (HSP) is 2.7%–30%, with varied average intervals between the first and second episodes. Few studies have explored the incidence and risk factors for recurrent HSP.

    Authors: Wei-Te Lei, Po-Li Tsai, Szu-Hung Chu, Yu-Hsuan Kao, Chien-Yu Lin, Li-Ching Fang, Shyh-Dar Shyur, Yu-Wen Lin and Shu-I Wu

    Citation: Pediatric Rheumatology 2018 16:25

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  17. Content type: Research article

    Rheumatic fever (RF) is the result of an autoimmune response to pharyngitis caused by infection with Streptococcus pyogenes. RF is most prevalent in Africa and the Middle East. Rheumatic heart disease (RHD) is th...

    Authors: Maher Hassan Gomaa, Shawkey Sadik Ali, Aya Mohamed Fattouh, Hala Salah Hamza and Mohamed Mohamed Badr

    Citation: Pediatric Rheumatology 2018 16:24

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  18. Content type: Research article

    Recently preliminary ultrasonography (US) definitions, in B mode, for normal components of pediatric joints have been developed by the OMERACT US group. The aim of the current study was to include Doppler find...

    Authors: P. Collado, D. Windschall, J. Vojinovic, S. Magni-Manzoni, P. Balint, G. A. W. Bruyn, C. Hernandez-Diaz, J. C. Nieto, V. Ravagnani, N. Tzaribachev, A. Iagnocco, M. A. D’Agostino and E. Naredo

    Citation: Pediatric Rheumatology 2018 16:23

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  19. Content type: Research article

    Systemic juvenile idiopathic arthritis (sJIA) is a complex disease with an autoinflammatory component of unknown etiology related to the innate immune system. A major role in the pathogenesis has been ascribed...

    Authors: M. Bielak, E. Husmann, N. Weyandt, J.-P. Haas, B. Hügle, G. Horneff, U. Neudorf, T. Lutz, E. Lilienthal, T. Kallinich, K. Tenbrock, R. Berendes, T. Niehues, H. Wittkowski, E. Weißbarth-Riedel, G. Heubner…

    Citation: Pediatric Rheumatology 2018 16:22

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  20. Content type: Research article

    Childhood-onset spondyloarthropathies usually start with enthesitis and peripheral arthritis. However, axial disease may develop afterward. Patients are most often classified, following revised (Edmonton 2011)...

    Authors: Maxime Goirand, Sylvain Breton, Frédéric Chevallier, Ngoc-Phoi Duong, Florence Uettwiller, Isabelle Melki, Richard Mouy, Carine Wouters, Brigitte Bader-Meunier, Chantal Job-Deslandre and Pierre Quartier

    Citation: Pediatric Rheumatology 2018 16:21

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  21. Content type: Research article

    Raynaud’s phenomenon (RP) is a functional vascular disease, presenting with recurrent episodes of ischemia of extremities in response to cold and emotional stress. Investigating cutaneous microcirculation is a...

    Authors: Bernadett Mosdósi, Kata Bölcskei and Zsuzsanna Helyes

    Citation: Pediatric Rheumatology 2018 16:20

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  22. Content type: Research article

    Withholding live-attenuated vaccines in patients using interleukin (IL)-1 or IL-6 blocking agents is recommended by guidelines for both pediatric and adult rheumatic diseases, since there is a risk of infectio...

    Authors: Jerold Jeyaratnam, Nienke M. ter Haar, Helen J. Lachmann, Ozgur Kasapcopur, Amanda K. Ombrello, Donato Rigante, Fatma Dedeoglu, Ezgi H. Baris, Sebastiaan J. Vastert, Nico M. Wulffraat and Joost Frenkel

    Citation: Pediatric Rheumatology 2018 16:19

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  23. Content type: Research article

    Self-management skills, including medication management, are vital to the health of adolescents and young adults with systemic lupus erythematosus (SLE). The purpose of this study was to assess the feasibility...

    Authors: Lisabeth V. Scalzi, Christopher S. Hollenbeak, Emily Mascuilli and Nancy Olsen

    Citation: Pediatric Rheumatology 2018 16:18

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  24. Content type: Short Report

    Anti-TNF (Tumor necrosis factor) therapy is effective in treating pediatric patients with refractory rheumatic disease. There is however a concern that anti-TNF usage may increase the risk of malignancy. Repor...

    Authors: Alexandra Okihiro, Rachana Hasija, Lillia Fung, Bonnie Cameron, Brian M. Feldman, Ronald Laxer, Rayfel Schneider, Earl Silverman, Lynn Spiegel, Rae S. M. Yeung and Shirley M. L. Tse

    Citation: Pediatric Rheumatology 2018 16:17

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  25. Content type: Research article

    Children with chronic rheumatic disease often require intravenous (IV) therapy. Our center has instituted standardized protocols for use of IV medications in rheumatology patients. Herein, we introduce the the...

    Authors: Surabhi S. Vinod, Annelle B. Reed, Jamelle Maxwell, Randy Q. Cron and Matthew L. Stoll

    Citation: Pediatric Rheumatology 2018 16:16

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  26. Content type: Research article

    The goal of this study was to apply the varicella zoster virus (VZV) vaccine to patients with pediatric rheumatic diseases (PRD) at risk for severe chickenpox, without interrupting their current immunosuppress...

    Authors: Fabian Speth, Claas H. Hinze, Susanne Andel, Thomas Mertens and Johannes-Peter Haas

    Citation: Pediatric Rheumatology 2018 16:15

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  27. Content type: Research article

    Proteinuria is a well-known risk factor for progression of renal dysfunction in a variety of chronic kidney diseases. In adult-onset Systemic Lupus Erytematosus (SLE) patients with lupus nephritis (LN), protei...

    Authors: Eve M. D. Smith, Peng Yin, Andrea L. Jorgensen and Michael W. Beresford

    Citation: Pediatric Rheumatology 2018 16:14

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  28. Content type: Research article

    Palindromic rheumatism is an idiopathic, periodic arthritis characterized by multiple, transient, recurring episodes. Palindromic rheumatism is well-characterized in adults, but has never been reported in pedi...

    Authors: Yonatan Butbul-Aviel, Yosef Uziel, Nofar Hezkelo, Riva Brik and Gil Amarilyo

    Citation: Pediatric Rheumatology 2018 16:12

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  29. Content type: Research article

    Methotrexate (MTX), commonly used in juvenile idiopathic arthritis (JIA), frequently has to be discontinued due to intolerance with anticipatory and associative gastrointestinal adverse effects. Eye Movement D...

    Authors: Lea Höfel, Bruno Eppler, Magdalena Storf, Elizabeth Schnöbel-Müller, Johannes-Peter Haas and Boris Hügle

    Citation: Pediatric Rheumatology 2018 16:11

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  30. Content type: Research article

    To assess the views of juvenile idiopathic arthritis (JIA) patients and their parents on the care and treatment they receive in referral pediatric rheumatology centers throughout Europe.

    Authors: E. H. Pieter. van Dijkhuizen, Tsipi Egert, Yona Egert, Wendy Costello, Casper Schoemaker, Marlous Fernhout, Mirjam Kepic, Alberto Martini, Silvia Scala, Ingrid Rotstein-Grein, Sebastiaan J. Vastert and Nico M. Wulffraat

    Citation: Pediatric Rheumatology 2018 16:10

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  31. Content type: Research article

    Adult-onset Still’s disease (AOSD) is an adult form of systemic juvenile idiopathic arthritis (JIA) that differs from the latter in its classification. This study evaluated the concordance between the Internat...

    Authors: Ji Won Yang, Eunyoung Lee, Ji-Yeon Seo, Ju-Yang Jung, Chang-Hee Suh and Hyoun-Ah Kim

    Citation: Pediatric Rheumatology 2018 16:9

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  32. Content type: Research article

    Up to 80% of children with juvenile idiopathic arthritis (JIA) develop arthritis involving their temporomandibular joint (TMJ). Recent studies have questioned the sensitivity of an abnormal MRI in the diagnosi...

    Authors: Matthew L. Stoll, Saurabh Guleria, Melissa L. Mannion, Daniel W. Young, Stuart A. Royal, Randy Q. Cron and Yoginder N. Vaid

    Citation: Pediatric Rheumatology 2018 16:8

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  33. Content type: Research article

    Systemic juvenile idiopathic arthritis (SJIA) is an autoinflammatory disease associated with chronic arthritis. Early diagnosis and effective therapy of SJIA is desirable, so that complications are avoided. Th...

    Authors: Claas H. Hinze, Dirk Holzinger, Elke Lainka, Johannes-Peter Haas, Fabian Speth, Tilmann Kallinich, Nikolaus Rieber, Markus Hufnagel, Annette F. Jansson, Christian Hedrich, Hanna Winowski, Thomas Berger, Ivan Foeldvari, Gerd Ganser, Anton Hospach, Hans-Iko Huppertz…

    Citation: Pediatric Rheumatology 2018 16:7

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  34. Content type: Research article

    Patients with sickle cell disease (SCD) present a defective activation of the alternate complement pathway that increases the risk of infection and is thought to predispose to autoimmune disease (AID). However...

    Authors: Valerie Li-Thiao-Te, Florence Uettwiller, Pierre Quartier, Florence Lacaille, Brigitte Bader-Meunier, Valentine Brousse and Mariane de Montalembert

    Citation: Pediatric Rheumatology 2018 16:5

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  35. Content type: Research article

    Childhood-onset systemic lupus erythematosus (c-SLE) is a chronic autoimmune disease which increases cardiovascular risk factors (CRF) such as elevated homocysteine, TNF-α, and hs-C reactive protein.

    Authors: Roberta Garcia Salomão, Luciana Martins de Carvalho, Clarice Izumi, Érika Silva Czernisz, José César Rosa, Sonir Roberto Rauber Antonini, Ana Carolina Bueno, Maria Olímpia Ribeiro do Vale Almada, Carolina de Almeida Coelho-Landell, Alceu Afonso Jordão, Virgínia Paes Leme Ferriani and Jacqueline Pontes Monteiro

    Citation: Pediatric Rheumatology 2018 16:4

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  36. Content type: Research article

    Our intent was to identify differences between the transcriptome of fibroblast-like synoviocytes (FLS) in oligoarticular juvenile idiopathic arthritis (JIA) before extension when compared to persistent subtype...

    Authors: AnneMarie C. Brescia, Megan M. Simonds, Suzanne M. McCahan, Kathleen E. Sullivan and Carlos D. Rose

    Citation: Pediatric Rheumatology 2018 16:3

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  37. Content type: Research article

    Systemic juvenile idiopathic arthritis (sJIA) is an auto-inflammatory disease characterized by fever, arthritis, and ≥1 of rash, generalized lymphadenopathy, hepato/splenomegaly, and serositis. Non-steroidal a...

    Authors: Anjali Sura, Christopher Failing, Julie Sturza, Jasmine Stannard and Meredith Riebschleger

    Citation: Pediatric Rheumatology 2018 16:2

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  38. Content type: Review

    Chronic Non-Bacterial Osteomyelitis (CNO) is an inflammatory disorder that primarily affects children. Although underestimated, its incidence is rare. For these reasons, no diagnostic and no therapeutic guidel...

    Authors: Andrea Taddio, Giovanna Ferrara, Antonella Insalaco, Manuela Pardeo, Massimo Gregori, Martina Finetti, Serena Pastore, Alberto Tommasini, Alessandro Ventura and Marco Gattorno

    Citation: Pediatric Rheumatology 2017 15:87

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  39. Content type: Research article

    Juvenile idiopathic arthritis (JIA) is the most common pediatric rheumatic disease and a leading cause of childhood disability. The objective of this study was to characterize the PK, safety, and taste accepta...

    Authors: Nicolino Ruperto, Hermine I. Brunner, Zbigniew Zuber, Nikolay Tzaribachev, Daniel J. Kingsbury, Ivan Foeldvari, Gerd Horneff, Elzbieta Smolewska, Richard K. Vehe, Anasuya Hazra, Rong Wang, Charles A. Mebus, Christine Alvey, Manisha Lamba, Sriram Krishnaswami, Thomas C. Stock…

    Citation: Pediatric Rheumatology 2017 15:86

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  40. Content type: Research article

    Behçet’s disease is a rare multi-systemic inflammatory disease with unknown etiology which involves principally oral and genital mucosa, skin and eyes. Average age at onset of the disease is about 25-30 years,...

    Authors: Romina Gallizzi, Caterina Pidone, Luca Cantarini, Martina Finetti, Marco Cattalini, Giovanni Filocamo, Antonella Insalaco, Donato Rigante, Rita Consolini, Maria Cristina Maggio, Adele Civino, Silvana Martino, Alma Nunzia Olivieri, Giovanna Fabio, Serena Pastore, Angela Mauro…

    Citation: Pediatric Rheumatology 2017 15:84

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    The Correction to this article has been published in Pediatric Rheumatology 2018 16:29

  41. Content type: Correction

    Familial Mediterranean Fever (FMF) is the most common inherited auto inflammatory disease, characterized by recurrent, self–limited attacks of fever and aseptic polyserositis.FMF is widespread in Armenia and t...

    Authors: Gayane Khloyan, Gayane Amaryan and Rotraud Saurenmann

    Citation: Pediatric Rheumatology 2017 15:83

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    The original article was published in Pediatric Rheumatology 2017 15:64

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