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  1. Precision health in adolescents relies on the successful collection of data and biospecimens from an adequately sized sample of cases and comparison group(s), often healthy controls, to answer the research que...

    Authors: Kimberly A. Lewis, Shelby Brooks, Ruy Carrasco, Patricia Carter, Alexandra Garcia, Jennifer Chiou, Christina Nguyen, Ambreen Rana, Sharon A. Brown, Stefano Tiziani and Nico Osier

    Citation: Pediatric Rheumatology 2021 19:169

    Content type: Research article

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  2. Childhood Polyarteritis nodosa (PAN) is a systemic vasculitis with necrotizing inflammation of medium- and small-sized arteries. Disease evolution may be severe and refractory to standard treatment including p...

    Authors: Margaux Boistault, Mireia Lopez Corbeto, Pierre Quartier, Laura Berbel Arcobé, Ariadna Carsi Durall and Florence A. Aeschlimann

    Citation: Pediatric Rheumatology 2021 19:168

    Content type: Case Report

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  3. The objective of this work was to describe magnetic resonance imaging (MRI) changes over time in inflammatory and structural lesions at the sacroiliac joint (SIJ) in children with spondyloarthritis (SpA) expos...

    Authors: Timothy G. Brandon, Rui Xiao, Rosemary G. Peterson, Nancy A. Chauvin, Michael L. Francavilla, David M. Biko, Dax G. Rumsey, Matthew L. Stoll and Pamela F. Weiss

    Citation: Pediatric Rheumatology 2021 19:167

    Content type: Research article

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  4. Juvenile Idiopathic Arthritis (JIA) is a group of chronic heterogenous disorders that manifests as joint inflammation in patients aged <16 years. Globally, approximately 3 million children and young adults are...

    Authors: Sulaiman M. Al-Mayouf, Muna Al Mutairi, Kenza Bouayed, Sara Habjoka, Djohra Hadef, Hala M. Lotfy, Cristiaan Scott, Elsadeg M. Sharif and Nouran Tahoun

    Citation: Pediatric Rheumatology 2021 19:166

    Content type: Review

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  5. The transition of health care from Pediatric to Adult providers for adolescents and young adults with chronic disease is associated with poor outcomes. Despite the importance of this transition, over 80% of th...

    Authors: Rebecca S. Overbury, Kelly Huynh, John Bohnsack, Tracy Frech and Aimee Hersh

    Citation: Pediatric Rheumatology 2021 19:164

    Content type: Research article

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  6. Flares of juvenile idiopathic arthritis (JIA) have been described in the context of various infections. Flares of rheumatic diseases in adults have been described following infection with SARS-CoV-2 in several...

    Authors: Boris Hügle, Manuela Krumrey-Langkammerer and Johannes-Peter Haas

    Citation: Pediatric Rheumatology 2021 19:163

    Content type: Research article

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  7. This study aimed to assess the baseline characteristics and clinical outcomes of coronavirus disease 2019 (COVID-19) in pediatric patients with rheumatic and musculoskeletal diseases (RMD) and identify the ris...

    Authors: Daniel Clemente, Clara Udaondo, Jaime de Inocencio, Juan Carlos Nieto, Pilar Galán del Río, Antía García Fernández, Jaime Arroyo Palomo, Javier Bachiller-Corral, Juan Carlos Lopez Robledillo, Claudia Millán Longo, Leticia Leon, Lydia Abasolo and Alina Boteanu

    Citation: Pediatric Rheumatology 2021 19:162

    Content type: Research article

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  8. Mevalonate kinase deficiency (MKD) is a rare autoinflammatory condition caused by biallelic loss-of-function (LOF) mutations in mevalonate kinase (MVK) gene encoding the enzyme mevalonate kinase. Patients with MK...

    Authors: Ebun Omoyinmi, Dorota Rowczenio, Neil Sebire, Paul A. Brogan and Despina Eleftheriou

    Citation: Pediatric Rheumatology 2021 19:161

    Content type: Case Report

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  9. Exercise has been suggested to prevent deterioration of health-related quality of life (HRQL) and overall health in pediatric rheumatologic diseases during the COVID-19 pandemic. Herein we describe the effects...

    Authors: Camilla Astley, Sofia Mendes Sieczkowska, Isabela Gouveia Marques, Bianca Pires Ihara, Livia Lindoso, Sofia Simão Martins Lavorato, Lucia Maria Arruda Campos, Rosa Maria Rodrigues Pereira, Adriana Maluf Elias, Nadia Emi Aikawa, Katia Kozu, Amanda Yuri Iraha, Tathiane Christine Franco, Hamilton Roschel, Ligia Bruni Queiroz, Guilherme Vanoni Polanczyk…

    Citation: Pediatric Rheumatology 2021 19:159

    Content type: Research article

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  10. Juvenile idiopathic arthritis (JIA) is the leading chronic rheumatic disease in childhood. To achieve adherence to therapy, in-depth understanding of disease and treatment options are important.

    Authors: Christiane Reiser, Nina A. Zeltner, Beatrix Rettenbacher, Petra Baumgaertner, Martina Huemer and Christian Huemer

    Citation: Pediatric Rheumatology 2021 19:158

    Content type: Research article

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  11. Kawasaki disease (KD) is a systemic vasculitis that predominantly affects medium-sized arteries. In addition to well-known coronary artery aneurysms (CAAs), peripheral systemic artery aneurysms (SAAs) have als...

    Authors: Chen Chu, Lan He, Yi-xiang Lin, Li-ping Xie and Fang Liu

    Citation: Pediatric Rheumatology 2021 19:157

    Content type: Case Report

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  12. Children report that they do not participate in their healthcare as much as they want, despite having the lawful right to form their own views and the right to express those views freely in all matters affecti...

    Authors: Veronica Lundberg, Catharina Eriksson, Torbjörn Lind, Imelda Coyne and Anncristine Fjellman-Wiklund

    Citation: Pediatric Rheumatology 2021 19:156

    Content type: Research article

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  13. Intra-articular venous malformations (IAVM) are rare benign vascular anomalies that usually affect young patients and most common locate in the knee. The terminology of these lesions is still ill-defined, as t...

    Authors: Federico Diomeda, Maria Santaniello, Giulia Bracciolini, Angelo Ravelli and Adele Civino

    Citation: Pediatric Rheumatology 2021 19:153

    Content type: Case Report

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  14. Juvenile Idiopathic Arthritis (JIA) requires complex care that generate elevated costs, which results in a high economic impact for the family. The aim of this systematic review was to collect and cluster the ...

    Authors: Fernando García-Rodríguez, Augusto Gamboa-Alonso, Sol Jiménez-Hernández, Lucero Ochoa-Alderete, Valeria Alejandra Barrientos-Martínez, Neri Alejandro Alvarez-Villalobos, Gabriela Andrea Luna-Ruíz, Ingris Peláez-Ballestas, Ana Victoria Villarreal-Treviño, Manuel Enrique de la O-Cavazos and Nadina Rubio-Pérez

    Citation: Pediatric Rheumatology 2021 19:152

    Content type: Review

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  15. The aim of the study was to investigate the relationship between the severity of typical clinical symptoms, severity of histopathological lesions in kidney biopsies in IgA vasculitis nephritis (IgAVN) and to p...

    Authors: Małgorzata Mizerska-Wasiak, Agnieszka Turczyn, Karolina Cichoń-Kawa, Jadwiga Małdyk, Monika Miklaszewska, Dorota Drożdż, Beata Bieniaś, Przemysław Sikora, Magdalena Drożyńska-Duklas, Aleksandra Żurowska, Maria Szczepańska and Małgorzata Pańczyk-Tomaszewska

    Citation: Pediatric Rheumatology 2021 19:150

    Content type: Research article

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  16. Chronic anterior uveitis is a sight-threatening complication of juvenile idiopathic arthritis (JIA) and a primary contributor to long-term morbidity in people with JIA. Levels of knowledge about uveitis among ...

    Authors: Ashley M. Cooper, Elaine R. Flanagan, Tova Ronis, Baruch Goldberg, Ashley K. Sherman, Chelsey Smith and Gary N. Holland

    Citation: Pediatric Rheumatology 2021 19:149

    Content type: Research article

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  17. Intravenous immunoglobulin (IVIG) resistance prediction is one of the primary clinical issues and study hotspots in KD. This study aimed to prospectively investigate the value of albumin-bilirubin grade (ALBI)...

    Authors: Yu Yan, Lina Qiao, Yimin Hua, Shuran Shao, Nanjun Zhang, Mei Wu, Lei Liu, Kaiyu Zhou, Xiaoliang Liu and Chuan Wang

    Citation: Pediatric Rheumatology 2021 19:147

    Content type: Research article

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  18. Juvenile Idiopathic Inflammatory Myopathies (IIM) are a group of rare diseases that are heterogeneous in terms of pathology that can include proximal muscle weakness, associated skin changes and systemic invol...

    Authors: Meredyth G. Ll Wilkinson, Claire T. Deakin, Charalampia Papadopoulou, Despina Eleftheriou and Lucy R. Wedderburn

    Citation: Pediatric Rheumatology 2021 19:146

    Content type: Review

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  19. The aetiology of juvenile idiopathic arthritis (JIA) is poorly understood. It has been shown that use of antibiotics is associated with JIA. However, whether the association is due to increased occurrence of i...

    Authors: Erik Kindgren and Johnny Ludvigsson

    Citation: Pediatric Rheumatology 2021 19:145

    Content type: Research article

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  20. Pleural effusion in systemic lupus erythematous (SLE) is a common symptom, and recent studies demonstrated that IL-6 has a pivotal role in its pathogenesis.

    Authors: Arianna De Matteis, Emanuela Sacco, Camilla Celani, Andrea Uva, Virginia Messia, Rebecca Nicolai, Manuela Pardeo, Fabrizio De Benedetti and Claudia Bracaglia

    Citation: Pediatric Rheumatology 2021 19:144

    Content type: Case Report

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  21. Although canakinumab has demonstrated efficacy in multiple trials in patients with periodic fever syndromes (PFS), the evidence on initiation of canakinumab among PFS patients in real world setting is not well...

    Authors: Peter Hur, Kathleen G. Lomax, Raluca Ionescu-Ittu, Ameur M. Manceur, Jipan Xie, Jordan Cammarota, Raju Gautam, Navneet Sanghera, Nina Kim and Alexei A. Grom

    Citation: Pediatric Rheumatology 2021 19:143

    Content type: Research article

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  22. Autoinflammatory diseases (AID) are rare chronic conditions with high disease burden, affecting children and adults. Clinically and genetically confirmed, AID can be effectively treated with targeted cytokine ...

    Authors: Tatjana Welzel, Anna L. Wildermuth, Norbert Deschner, Susanne M. Benseler and Jasmin B. Kuemmerle-Deschner

    Citation: Pediatric Rheumatology 2021 19:142

    Content type: Research article

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  23. The ACR 1997, SLICC 2012 and EULAR/ACR 2019 classification criteria were validated based on adult patients. To date, there are no classification criteria specific for children with SLE. The aim of the study is...

    Authors: Reem Abdwani, Eman Al Masroori, Eiman Abdullah, Safiya Al Abrawi and Ibrahim Al-Zakwani

    Citation: Pediatric Rheumatology 2021 19:141

    Content type: Research article

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    The Correction to this article has been published in Pediatric Rheumatology 2021 19:165

  24. Surgeries for idiopathic uveitis and juvenile idiopathic arthritis-associated uveitis in children are complex because of the high risk of inflammatory postoperative complications. There is no consensus about t...

    Authors: Julie Molimard, Christine Pajot, Priscille Olle, Alexandre Belot, Pierre Quartier, Florence Uettwiller, Chloé Couret, Valentine Coste, Camille Costet, Bahram Bodaghi, Pascal Dureau, Marion Bailhache and Pascal Pillet

    Citation: Pediatric Rheumatology 2021 19:139

    Content type: Research article

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  25. This case study documents the first familial case of Blau syndrome (BS) in Palestine characterized with mutation in CARD15/NOD2.

    Authors: Salam Iriqat, Mohammed Abu Safieh, Manuel Fatouleh and Abdulsalam Alkaiyat

    Citation: Pediatric Rheumatology 2021 19:138

    Content type: Case Report

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  26. Consensus treatment plans have been developed for induction therapy of newly diagnosed proliferative lupus nephritis (LN) in childhood-onset systemic lupus erythematosus. However, patients who do not respond t...

    Authors: Mileka Gilbert, Beatrice Goilav, Joyce J. Hsu, Paul J. Nietert, Esra Meidan, Annabelle Chua, Stacy P. Ardoin, Scott E. Wenderfer, Emily von Scheven and Natasha M. Ruth

    Citation: Pediatric Rheumatology 2021 19:137

    Content type: Research article

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  27. The importance of developmentally appropriate transitional care in young people with juvenile-onset rheumatic and musculoskeletal disease is well recognised. The Paediatric Rheumatology European Society (PReS)...

    Authors: Janet E. McDonagh, Rachel Tattersall, Jacqui Clinch, Joanne Swan, Helen E. Foster and Liza McCann

    Citation: Pediatric Rheumatology 2021 19:136

    Content type: Review

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  28. Juvenile idiopathic arthritis (JIA) is the most common paediatric rheumatological disorder and is classified by subtype according to International League of Associations for Rheumatology criteria. Depending on...

    Authors: Lina N. Zaripova, Angela Midgley, Stephen E. Christmas, Michael W. Beresford, Eileen M. Baildam and Rachel A. Oldershaw

    Citation: Pediatric Rheumatology 2021 19:135

    Content type: Review

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  29. Juvenile idiopathic arthritis (JIA), is the most common pediatric rheumatologic disorder with unknown etiology. Currently, no population-based data are available regarding the distribution of categories and fr...

    Authors: Sezgin Sahin, Ceyhun Acari, Hafize Emine Sonmez, Fatma Zehra Kilic, Erdal Sag, Hatice Adiguzel Dundar, Amra Adrovic, Selcan Demir, Kenan Barut, Yelda Bilginer, Betul Sozeri, Erbil Unsal, Seza Ozen and Ozgur Kasapcopur

    Citation: Pediatric Rheumatology 2021 19:134

    Content type: Research article

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  30. We aimed to characterize etanercept (ETN) use in juvenile idiopathic arthritis (JIA) patients enrolled in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry.

    Authors: Timothy Beukelman, Aimee Lougee, Roland A. Matsouaka, David Collier, Dax G. Rumsey, Jennifer Schenfeld, Scott Stryker, Marinka Twilt and Yukiko Kimura

    Citation: Pediatric Rheumatology 2021 19:131

    Content type: Research article

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  31. Juvenile idiopathic arthritis constitutes a significant cause of disability and quality of life impairment in pediatric and adult patients. The aim of this study was to ascertain clinical remission (CR) and su...

    Authors: Mireia Castillo-Vilella, Nuria Giménez, Jose Luis Tandaipan, Salvador Quintana and Consuelo Modesto

    Citation: Pediatric Rheumatology 2021 19:130

    Content type: Research article

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  32. The curriculum for professionals working in paediatric rheumatology should include pain but it is unclear to what extent this currently occurs. The aim of this study was to identify pain-related curriculum con...

    Authors: Rebecca Rachael Lee, Janet E. McDonagh, Mark Connelly, Sarah Peters and Lis Cordingley

    Citation: Pediatric Rheumatology 2021 19:129

    Content type: Research article

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  33. Juvenile-onset Fibromyalgia (JFM) is a chronic pain condition characterized by widespread musculoskeletal pain, fatigue, sleep difficulties, mood concerns, and other associated symptoms. Although diagnosed in ...

    Authors: Morgan Daffin, Mary K. Lynch-Milder, Robert C. Gibler, Caitlin Murray, Carly M. Green and Susmita Kashikar-Zuck

    Citation: Pediatric Rheumatology 2021 19:128

    Content type: Research article

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  34. High-intensity glucocorticoid regimens are commonly used to induce and maintain remission in Juvenile Dermatomyositis but are associated with several adverse side-effects. Evidence-based treatment guidelines f...

    Authors: Amir B. Orandi, Lampros Fotis, Jamie Lai, Hallie Morris, Andrew J. White, Anthony R. French and Kevin W. Baszis

    Citation: Pediatric Rheumatology 2021 19:127

    Content type: Research article

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  35. Mutations along PSTPIP1 gene are associated to two specific conditions, PAPA syndrome and PAMI syndrome, both autoinflammatory disorders associated to disturbances in cytoskeleton formation. Immunological aspe...

    Authors: Leonardo Oliveira Mendonça, Maria Teresa Terreri, Fabiane Mitie Osaku, Samar Freschi Barros, Karen Francine Köhler, Alex Isidoro Prado, Myrthes Toledo Barros, Jorge Kalil and Fabio Fernandes Morato Castro

    Citation: Pediatric Rheumatology 2021 19:126

    Content type: Research article

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  36. Based on the recently developed ChRonic nonbacterial Osteomyelitis MRI Scoring tool (CROMRIS), we developed a radiological activity index (RAI-CROMRIS) to obtain a quantification of the overall bone involvemen...

    Authors: Martina Capponi, Denise Pires Marafon, Flaminia Rivosecchi, Yongdong Zhao, Manuela Pardeo, Virginia Messia, Laura Tanturri de Horatio, Paolo Tomà, Fabrizio De Benedetti and Antonella Insalaco

    Citation: Pediatric Rheumatology 2021 19:123

    Content type: Research article

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  37. The impact of social determinants of health on children with polyarticular juvenile idiopathic arthritis (pJIA) is poorly understood. Prompt initiation of treatment for pJIA is important to prevent disease mor...

    Authors: Nayimisha Balmuri, William Daniel Soulsby, Victoria Cooley, Linda Gerber, Erica Lawson, Susan Goodman, Karen Onel and Bella Mehta

    Citation: Pediatric Rheumatology 2021 19:122

    Content type: Research article

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  38. Mendelian susceptibility to mycobacterial disease (MSMD) is an inborn error of immunity, resulting in susceptibility to weakly virulent mycobacteria and other intramacrophagic pathogens. Rheumatologic manifest...

    Authors: Niusha Sharifinejad, Seyed Alireza Mahdaviani, Mahnaz Jamee, Zahra Daneshmandi, Afshin Moniri, Majid Marjani, Payam Tabarsi, Parisa Farnia, Mahsa Rekabi, Mazdak Fallahi, Seyedeh Atefeh Hashemimoghaddam, Masoumeh Mohkam, Jacinta Bustamante, Jean-Laurent Casanova, Davood Mansouri and Ali Akbar Velayati

    Citation: Pediatric Rheumatology 2021 19:121

    Content type: Case Report

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