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  1. Considerable therapeutic advances for the treatment of vasculitis of the young have been made in the past 10 years, including the development of outcome measures that facilitate clinical trial design. Notably,...

    Authors: Despina Eleftheriou and Paul A. Brogan
    Citation: Pediatric Rheumatology 2016 14:26
    Content type: Review Published on:

  2. Juvenile idiopathic arthritis (JIA) is an autoimmune disease characterized by persistent chronic arthritis. Disease risk is believed to be influenced by both genetic and environmental factors. It is well estab...

    Authors: G. N. Goulielmos, R. C. Chiaroni-Clarke, D. G. Dimopoulou, M. I. Zervou, M. Trachana, P. Pratsidou-Gertsi, A. Garyfallos and J. A. Ellis
    Citation: Pediatric Rheumatology 2016 14:25
    Content type: Short Report Published on:

  3. Temporomandibular joint (TMJ) arthritis is seen very often (38–87 %) in children with juvenile idiopathic arthritis (JIA). With contrast enhanced magnetic resonance imaging (MRI) we can detect more cases of TM...

    Authors: Zane Dāvidsone, Jeļena Eglīte, Arina Lazareva, Sarmīte Dzelzīte, Ruta Šantere, Dace Bērziņa and Valda Staņēviča
    Citation: Pediatric Rheumatology 2016 14:24
    Content type: Research article Published on:

  4. Juvenile idiopathic arthritis (JIA), as a chronic condition, is associated with significant disease- and treatment-related morbidity, thus impacting children’s quality of life. In order to optimize JIA managem...

    Authors: Alessandro Consolaro, Gabriella Giancane, Benedetta Schiappapietra, Sergio Davì, Serena Calandra, Stefano Lanni and Angelo Ravelli
    Citation: Pediatric Rheumatology 2016 14:23
    Content type: Review Published on:

  5. Kawasaki disease (KD) is a systemic vasculitis with an acute and self-limited course. The incidence of KD differs widely among ethnic groups and is higher in the Asian population. In Italy, no recent data are ...

    Authors: Angela Mauro, Marianna Fabi, Monica Da Frè, Paolo Guastaroba, Elena Corinaldesi, Giovanni Battista Calabri, Teresa Giani, Gabriele Simonini, Franca Rusconi and Rolando Cimaz
    Citation: Pediatric Rheumatology 2016 14:22
    Content type: Research article Published on:

  7. Although joint involvement is the second most common clinical manifestation after skin involvement in patients with Henoch-Schönlein purpura (HSP), it has not been well characterized. The aim of this study was...

    Authors: Xuehong Wang, Yongmei Zhu, Laiqiang Gao, Shuyue Wei, Youyou Zhen and Qiang Ma
    Citation: Pediatric Rheumatology 2016 14:20
    Content type: Research article Published on:

  8. Mevalonate kinase deficiency is a metabolic autoinflammatory syndrome caused by mutations in the MVK gene, mevalonate kinase, the key enzyme in the non-sterol isoprenoid biosynthesis pathway. Two phenotypes of me...

    Authors: Skaiste Peciuliene, Birute Burnyte, Rymanta Gudaitiene, Skirmante Rusoniene, Nijole Drazdiene, Arunas Liubsys and Algirdas Utkus
    Citation: Pediatric Rheumatology 2016 14:19
    Content type: Case Report Published on:

  9. Immunoglobulin G4-related disease (IgG4-RD) is a systemic fibro-inflammatory condition with an unclear pathophysiological mechanism affecting different parts of the body. If untreated, the disease can lead to ...

    Authors: Faiz Karim, Jan Loeffen, Wichor Bramer, Lauren Westenberg, Rob Verdijk, Martin van Hagen and Jan van Laar
    Citation: Pediatric Rheumatology 2016 14:18
    Content type: Review Published on:

  10. The juvenile spondyloarthropathies (JSpA) are a group of related rheumatic diseases characterized by involvement of peripheral large joints, axial joints, and entheses (enthesitis) that begin in the early year...

    Authors: María Martha Katsicas and Ricardo Russo
    Citation: Pediatric Rheumatology 2016 14:17
    Content type: Review Published on:

  11. Sports participation can be an integral part of adolescent development with numerous positive short and long-term effects. Despite these potential benefits very high levels of physical activity, during skeleta...

    Authors: Viran de Silva, Michael Swain, Carolyn Broderick and Damien McKay
    Citation: Pediatric Rheumatology 2016 14:16
    Content type: Review Published on:

  12. Epidemiological research reveals that the incidence of allergic diseases and that of autoimmune diseases have been increasing in parallel, raising an interest in a potential link between the two disorders. How...

    Authors: Chien-Heng Lin, Cheng-Li Lin, Te-Chun Shen and Chang-Ching Wei
    Citation: Pediatric Rheumatology 2016 14:15
    Content type: Research article Published on:

  13. Clinically distinct autoimmune phenotypes share genetic susceptibility factors. We investigated the prevalence of familial autoimmunity among subjects with juvenile idiopathic arthritis (JIA), childhood system...

    Authors: Sampath Prahalad, Courtney E. McCracken, Lori A. Ponder, Sheila T. Angeles-Han, Kelly A. Rouster Stevens, Larry B. Vogler, Carl D. Langefeld and Susan D. Thompson
    Citation: Pediatric Rheumatology 2016 14:14
    Content type: Research article Published on:

  14. Despite the wealth of clinical research carried out in children with juvenile idiopathic arthritis (JIA), little is known about the emotional experiences of their parents. This article describes the predominan...

    Authors: Oralia Gómez-Ramírez, Michele Gibbon, Roberta Berard, Roman Jurencak, Jayne Green, Lori Tucker, Natalie Shiff and Jaime Guzman
    Citation: Pediatric Rheumatology 2016 14:13
    Content type: Research article Published on:

  15. Patients with Systemic Lupus Erythematosus (SLE) are at increased risk for infections. Vaccination is a powerful tool to prevent infections, even in immunocompromised patients. Most non-live vaccines are immun...

    Authors: Ingrid Herta Rotstein Grein, Noortje Groot, Marcela Ignacchiti Lacerda, Nico Wulffraat and Gecilmara Pileggi
    Citation: Pediatric Rheumatology 2016 14:12
    Content type: Review Published on:

  16. Methotrexate (MTX) intolerance is a frequent problem of long-term treatment in juvenile idiopathic arthritis (JIA). Mutations in the methylentetrahydrofolate reductase (MTHFR) gene may increase toxicity of MTX...

    Authors: Andrea Scheuern, Nadine Fischer, Joseph McDonald, Hermine I. Brunner, Johannes-Peter Haas and Boris Hügle
    Citation: Pediatric Rheumatology 2016 14:11
    Content type: Short Report Published on:

  17. BD is a systemic inflammatory disease with a variable vasculitis. Paediatric onset is very rare and carries a strong genetic component. Oral ulcers and fever of unknown origin are frequent at onset and difficu...

    Authors: Isabelle Koné-Paut
    Citation: Pediatric Rheumatology 2016 14:10
    Content type: Review Published on:

  18. There is not yet a commonly accepted, standardized approach in the treatment of juvenile idiopathic uveitis when initial steroid therapy is insufficient. We sought to assess current practice patterns within a ...

    Authors: Lauren A. Henderson, David Zurakowski, Sheila T. Angeles-Han, Andrew Lasky, C. Egla Rabinovich and Mindy S. Lo
    Citation: Pediatric Rheumatology 2016 14:9
    Content type: Research article Published on:

  19. The association between rheumatoid arthritis (RA) and periodontitis is well established. Some children with juvenile idiopathic arthritis (JIA) phenotypically resemble adults with RA, characterized by the pres...

    Authors: Lauren Lange, Geoffrey M. Thiele, Courtney McCracken, Gabriel Wang, Lori A. Ponder, Sheila T. Angeles-Han, Kelly A. Rouster-Stevens, Aimee O. Hersh, Larry B. Vogler, John F. Bohnsack, Shelly Abramowicz, Ted R. Mikuls and Sampath Prahalad
    Citation: Pediatric Rheumatology 2016 14:8
    Content type: Research article Published on:

  20. Various pathways involved in the pathogenesis of sJIA have been identified through gene expression profiling in peripheral blood mononuclear cells (PBMC), but not in neutrophils. Since neutrophils are importan...

    Authors: Ebun Omoyinmi, Raja Hamaoui, Annette Bryant, Mike Chao Jiang, Trin Athigapanich, Despina Eleftheriou, Mike Hubank, Paul Brogan and Patricia Woo
    Citation: Pediatric Rheumatology 2016 14:7
    Content type: Research article Published on:

  21. Several medications for treatment of Juvenile Idiopathic Arthritis (JIA) are considered to be carcinogenic. Therefore, the aim was to assess whether there is an association between therapeutic interventions an...

    Authors: Swaantje Barth, Jenny Schlichtiger, Betty Bisdorff, Boris Hügle, Hartmut Michels, Katja Radon and Johannes-Peter Haas
    Citation: Pediatric Rheumatology 2016 14:6
    Content type: Short Report Published on:

  22. The Editors of Pediatric Rheumatology would like to thank all our reviewers who have contributed to the journal in Volume 13 (2015).

    Authors: Alberto Martini and Charles Spencer
    Citation: Pediatric Rheumatology 2016 14:5
    Content type: Reviewer acknowledgement Published on:

  23. MicroRNAs (miRNAs) are involved in the post-transcriptional regulation of genes. The objective of this study was to investigate whether select urinary cell-free microRNA’s may serve as biomarkers in children w...

    Authors: Khalid M. Abulaban, Ndate Fall, Ravi Nunna, Jun Ying, Prasad Devarajan, Alexi Grom, Michael Bennett, Stacy P. Ardoin and Hermine I. Brunner
    Citation: Pediatric Rheumatology 2016 14:4
    Content type: Research article Published on:

  24. Many studies show that Juvenile Idiopathic Arthritis (JIA) is associated with early subclinical signs of atherosclerosis. Chronic inflammation per se may be an important driver but other known risk factors, such ...

    Authors: Anna-Helene Bohr, Robert C. Fuhlbrigge, Freddy Karup Pedersen, Sarah D. de Ferranti and Klaus Müller
    Citation: Pediatric Rheumatology 2016 14:3
    Content type: Review Published on:

  25. The JAMAR (Juvenile Arthritis Multidimensional Assessment Report) has been developed to evaluate the perception of the patient and his parents on different items: well-being, pain, functional status, quality o...

    Authors: Federica Vanoni, Joan-Carles Suris, Annette von Scheven-Gête, Béatrice Fonjallaz and Michaël Hofer
    Citation: Pediatric Rheumatology 2016 14:2
    Content type: Research article Published on:

  26. We describe the collaborative development of an evidence based, free online resource namely ‘paediatric musculoskeletal matters’ (pmm). This resource was developed with the aim of reaching a wide range of heal...

    Authors: Nicola Smith, Tim Rapley, Sharmila Jandial, Christine English, Barbara Davies, Ruth Wyllie and Helen E. Foster
    Citation: Pediatric Rheumatology 2016 14:1
    Content type: Research article Published on:

  27. Temporomandibular joint (TMJ) inflammation in patients with juvenile idiopathic arthritis (JIA) can lead to orofacial pain and malfunction of the TMJ. Intra-articular corticosteroid injections (IACI) have been...

    Authors: Peter Stoustrup, Kasper Dahl Kristensen, Annelise Küseler, Thomas Klit Pedersen and Troels Herlin
    Citation: Pediatric Rheumatology 2015 13:62
    Content type: Research article Published on:

  28. IL-12p40 plays an important role in the activation of the T-cell lines like Th17 and Th1-cells. Theses cells are crucial in the pathogenesis of juvenile idiopathic arthritis. A polymorphism in its promoter reg...

    Authors: Christiane S. Eberhardt, Johannes-Peter Haas, Hermann Girschick, Tobias Schwarz, Henner Morbach, Angela Rösen-Wolff, Dirk Foell, Guenther Dannecker, Carsten Schepp, Gerd Ganser, Nora Honke, Thomas Eggermann, Jan Müller-Berghaus, Norbert Wagner, Kim Ohl and Klaus Tenbrock
    Citation: Pediatric Rheumatology 2015 13:61
    Content type: Research article Published on:

  30. Familial Mediterranean fever (FMF) is one of the most frequent genetic diseases encountered in the Mediterranean region. We aimed to investigate the correlation between genetic mutations and the clinical findi...

    Authors: Ayse Kilic, Muhammet Ali Varkal, Mehmet Sait Durmus, Ismail Yildiz, Zeynep Nagihan Yürük Yıldırım, Gorkem Turunc, Fatma Oguz, Mujgan Sidal, Rukiye Eker Omeroglu, Sevinc Emre, Yasin Yilmaz, Fatih Mehmet Kelesoglu, Genco Ali Gencay, Sonay Temurhan, Filiz Aydin and Emin Unuvar
    Citation: Pediatric Rheumatology 2015 13:59
    Content type: Research article Published on:

  31. Children and young people (CYP) with juvenile idiopathic arthritis (JIA) are known to have impaired health-related quality of life (HRQoL), which is improved significantly for many by treatment with methotrexa...

    Authors: Kathleen Mulligan, Lucy R Wedderburn and Stanton Newman
    Citation: Pediatric Rheumatology 2015 13:58
    Content type: Research article Published on:

  32. Vascular health is of concern in patients with Juvenile Idiopathic Arthritis (JIA) since Rheumatoid Arthritis (RA) epidemiologically has a well-described association with premature development of atheroscleros...

    Authors: Anna-Helene Bohr, Susan Nielsen, Klaus Müller, Freddy Karup Pedersen and Lars Bo Andersen
    Citation: Pediatric Rheumatology 2015 13:57
    Content type: Research article Published on:

  33. To test clinical findings associated with early temporomandibular joint (TMJ) arthritis in comparison to the current gold standard contrast enhanced magnetic resonance imaging (MRI) in children with juvenile i...

    Authors: Heidi Keller, Lukas Markus Müller, Goran Markic, Thomas Schraner, Christian Johannes Kellenberger and Rotraud Katharina Saurenmann
    Citation: Pediatric Rheumatology 2015 13:56
    Content type: Research article Published on:

  34. Macrophage activation syndrome (MAS) is a severe and potentially lethal complication of several inflammatory diseases but seems particularly linked to systemic juvenile idiopathic arthritis (sJIA). Standardize...

    Authors: V. Boom, J. Anton, P. Lahdenne, P. Quartier, A. Ravelli, N.M. Wulffraat and S.J. Vastert
    Citation: Pediatric Rheumatology 2015 13:55
    Content type: Research article Published on:

  35. Adult patients receiving anti-TNFα drugs are at increased risk of tuberculosis (TB), but studies in pediatric populations are limited, and the best strategy for latent tuberculosis infection (LTBI) screening i...

    Authors: Joan Calzada-Hernández, Jordi Anton-López, Rosa Bou-Torrent, Estíbaliz Iglesias-Jiménez, Sílvia Ricart-Campos, Javier Martín de Carpi, Vicenç Torrente-Segarra, Judith Sánchez-Manubens, Clara Giménez-Roca, Librada Rozas-Quesada, Maria Teresa Juncosa-Morros, Clàudia Fortuny and Antoni Noguera-Julian
    Citation: Pediatric Rheumatology 2015 13:54
    Content type: Research article Published on:

  36. Currently there is no consensus agreement on the degree of enhancement in normal temporomandibular joints (TMJ) in children, which makes it difficult for clinicians to distinguish between the presence/absence ...

    Authors: Grace Mang Yuet Ma, Afsaneh Amirabadi, Emilio Inarejos, Mirkamal Tolend, Jennifer Stimec, Rahim Moineddin, Lynn Spiegel and Andrea S. Doria
    Citation: Pediatric Rheumatology 2015 13:53
    Content type: Research article Published on:

  37. Untreated mental health problems may result in poor outcomes for youth with systemic lupus erythematosus (SLE) and mixed connective tissue disease (MCTD). We investigated perceptions, barriers and facilitators...

    Authors: Andrea M. Knight, Michelle E. Vickery, Alexander G. Fiks and Frances K. Barg
    Citation: Pediatric Rheumatology 2015 13:52
    Content type: Research article Published on:

  38. Our aim was to investigate the prevalence and clinical relevance of inherited complement and antibody deficiency states in a large series of patients with various autoimmune rheumatologic diseases (ARD) with j...

    Authors: Mihaela Spârchez, Iulia Lupan, Dan Delean, Aurel Bizo, Laura Damian, Laura Muntean, Maria Magdalena Tămaș, Claudia Bolba, Bianca Simionescu, Cristina Slăvescu, Ioana Felea, Călin Lazăr, Zeno Spârchez and Simona Rednic
    Citation: Pediatric Rheumatology 2015 13:51
    Content type: Research article Published on:

  39. Adult-onset Still’s disease (AOSD), a rare autoinflammatory disorder, resembles systemic juvenile idiopathic arthritis (SJIA). The superimposable systemic clinical features of AOSD and SJIA suggest both clinic...

    Authors: Nanguneri Nirmala, Arndt Brachat, Eugen Feist, Norbert Blank, Christof Specker, Matthias Witt, Jan Zernicke, Alberto Martini and Guido Junge
    Citation: Pediatric Rheumatology 2015 13:50
    Content type: Short Report Published on:

  40. Macrophage activation syndrome (MAS) is the secondary hemophagocytic lymphohistiocytosis associated with rheumatic diseases. Recently, the different cytokine profiles between systemic juvenile idiopathic arthr...

    Authors: Hiroyuki Wakiguchi, Shunji Hasegawa, Reiji Hirano, Hidenobu Kaneyasu, Midori Wakabayashi-Takahara and Shouichi Ohga
    Citation: Pediatric Rheumatology 2015 13:49
    Content type: Case Report Published on:

  41. Primary haemophagocytic lymphohistiocytosis (HLH) screening assays are increasingly being performed in patients presenting with macrophage activation syndrome (MAS). The objective of this study was to describe...

    Authors: Mary Cruikshank, Parameswaran Anoop, Olga Nikolajeva, Anupama Rao, Kanchan Rao, Kimberly Gilmour, Despina Eleftheriou and Paul A Brogan
    Citation: Pediatric Rheumatology 2015 13:48
    Content type: Research article Published on:

  42. Liver disease is rare in the course of mixed connective tissue disease. Most commonly liver steatosis or elevated liver function tests are reported and only a few cases of mixed connective tissue disease assoc...

    Authors: Katarina Sedej, Nataša Toplak, Marina Praprotnik, Boštjan Luzar, Jernej Brecelj and Tadej Avčin
    Citation: Pediatric Rheumatology 2015 13:47
    Content type: Case Report Published on:

  43. To determine the prevalence and diagnostic value of pelvic enthesitis on MRI of the sacroiliac (SI) joints in enthesitis related arthritis (ERA).

    Authors: N. Herregods, J. Dehoorne, E. Pattyn, J. L. Jaremko, X. Baraliakos, D. Elewaut, J Van Vlaenderen, F. Van den Bosch, R. Joos, K. Verstraete and L. Jans
    Citation: Pediatric Rheumatology 2015 13:46
    Content type: Research article Published on:

  45. No standard treatment protocol exists for Kawasaki disease (KD) after spontaneous defervescence that does not use intravenous immunoglobulin (IVIG). Moreover, some cases present an indolent course and later de...

    Authors: Takuto Takahashi, Hiroshi Sakakibara, Yoshihiko Morikawa and Masaru Miura
    Citation: Pediatric Rheumatology 2015 13:44
    Content type: Research article Published on:

  46. Muckle-Wells-syndrome (MWS) is an autoinflammatory disease characterized by systemic and organ-specific inflammation due to excessive interleukin (IL)-1 release. Inner ear inflammation results in irreversible ...

    Authors: Jasmin B. Kuemmerle-Deschner, Assen Koitschev, Pascal N. Tyrrell, Stefan K. Plontke, Norbert Deschner, Sandra Hansmann, Katharina Ummenhofer, Peter Lohse, Christiane Koitschev and Susanne M. Benseler
    Citation: Pediatric Rheumatology 2015 13:43
    Content type: Research article Published on:

  47. We sought to identify which adolescent patient characteristics might lead to subjective reported independence in accessing medical care when patients transition from pediatric to adult medicine.

    Authors: Catherine April Bingham, Lisabeth Scalzi, Brandt Groh, Susan Boehmer and Sharon Banks
    Citation: Pediatric Rheumatology 2015 13:42
    Content type: Research article Published on:

  48. Youth with juvenile idiopathic arthritis (JIA) may be at risk of poor cardiovascular health. Circulating endothelial progenitor cells (EPCs) and circulating endothelial cells (CECs) are markers of cardiovascul...

    Authors: Joyce Obeid, Thanh Nguyen, Tania Cellucci, Maggie J. Larché and Brian W. Timmons
    Citation: Pediatric Rheumatology 2015 13:41
    Content type: Research article Published on:

  49. Linear atrophoderma of Moulin (LAM) is an acquired skin condition that manifests in early childhood and adolescence. It likely represents a form of cutaneous mosaicism that presents with linear, hyperpigmented...

    Authors: Omid Zahedi niaki, Wendy Sissons, Van-Hung Nguyen, Ramin Zargham and Fatemeh Jafarian
    Citation: Pediatric Rheumatology 2015 13:39
    Content type: Case Report Published on:

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Pediatric Rheumatology

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