Table 4 Comparison of circulating cytokines in MIS-C patients
Cytokines, fold difference [Q1, Q3] | All MIS-C | IVIG monotherapy | All IVIG + anakinra | p-value |
|---|---|---|---|---|
IFNγ | 1.0 [0.4–1.6] | 0.4 [0.40–1.2] | 1.0 [0.5–2.1] | 0.07 |
IL-1β | 0.9 [0.2–1.0] | 0.9 [0.7–0.9] | 0.9 [0.2–1.0] | 0.37 |
IL-2 | 1.0 [1.0–1.0] | 1.0 [1.0–1.0] | 1.0 [1.0–1.0] | 0.74 |
IL-6 | 14.3 [3.2–34.4] | 3.0 [1.6–15.8] | 22.1 [9.9–39.0] | 0.006 |
IL-8 | 0.6 [0.3–1.0] | 0.3 [0.3–0.6] | 1.0 [0.3–1.0] | 0.03 |
IL-12 | 0.4 [0.4–1.0] | 0.4 [0.4–0.4] | 0.7 [0.4–1.0] | 0.10 |
IL-17 | 1.0 [0.6–1.6] | 1.0 [0.6–3.0] | 1.0 [0.6–1.0] | 0.98 |
sIL-2R | 4.0 [2.0–6.7] | 1.4 [0.9–3.2] | 5.7 [3.7–7.8] | 0.0006 |
TNFα | 0.3 [0.1–0.5] | 0.2 [0.1–0.3] | 0.3 [0.2–0.6] | 0.11 |