Lelieveld OTHM, van Brussel M, Takken T, van Weert E, van Leeuwen MA, Armbrust W. Aerobic and anaerobic exercise capacity in adolescents with juvenile idiopathic arthritis. Arthritis Rheum. 2007;57:898–904.
Article
Google Scholar
Perandini LA, de Sá-Pinto AL, Roschel H, Benatti FB, Lima FR, Bonfá E, et al. Exercise as a therapeutic tool to counteract inflammation and clinical symptoms in autoimmune rheumatic diseases. Autoimmun Rev. 2012;12:218–24.
Article
Google Scholar
Cavallo S, April KT, Grandpierre V, Majnemer A, Feldman DE. Leisure in children and adolescents with juvenile idiopathic arthritis: a systematic review. PLoS One. 2014;9:e104642.
Article
Google Scholar
Limenis E, Grosbein HA, Feldman BM. The relationship between physical activity levels and pain in children with juvenile idiopathic arthritis. J Rheumatol. 2014;41:345–51.
Article
Google Scholar
Brabnikova Maresova K, Jarosova K, Pavelka K, Stepan JJ. The association between lean mass and bone mineral content in the high disease activity group of adult patients with juvenile idiopathic arthritis. BMC Musculoskelet Disord. 2014;15:51.
Article
Google Scholar
Bechtold S, Roth J. Natural history of growth and body composition in juvenile idiopathic arthritis. Horm Res. 2009;72(Suppl 1):13–9.
Article
CAS
Google Scholar
Gualano B, Bonfa E, Pereira RMR, Silva CA. Physical activity for paediatric rheumatic diseases: standing up against old paradigms. Nat Rev Rheumatol. 2017;13:368–79.
Article
Google Scholar
Bruce CR, Dyck DJ. Cytokine regulation of skeletal muscle fatty acid metabolism: effect of interleukin-6 and tumor necrosis factor-alpha. Am J Physiol Endocrinol Metab. 2004;287:E616–21.
Article
CAS
Google Scholar
da Silva BSP, Bonfá E, de Moraes JCB, Saad CGS, de Medeiros Ribeiro AC, Gonçalves CR, et al. Effects of anti-TNF therapy on glucose metabolism in patients with ankylosing spondylitis, psoriatic arthritis or juvenile idiopathic arthritis. Biologicals. 2010;38:567–9.
Article
Google Scholar
Chen X, Xun K, Chen L, Wang Y. TNF-alpha, a potent lipid metabolism regulator. Cell Biochem Funct. 2009;27:407–16.
Article
CAS
Google Scholar
Romijn JA, Coyle EF, Sidossis LS, Gastaldelli A, Horowitz JF, Endert E, et al. Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration. Am J Phys. 1993;265:E380–91.
CAS
Google Scholar
Riddell MC, Bar-Or O, Wilk B, Parolin ML, Heigenhauser GJ. Substrate utilization during exercise with glucose and glucose plus fructose ingestion in boys ages 10--14 yr. J Appl Physiol (1985). 2001;90(3):903-11.
Article
CAS
Google Scholar
Achten J, Venables MC, Jeukendrup AE. Fat oxidation rates are higher during running compared with cycling over a wide range of intensities. Metab Clin Exp. 2003;52:747–52.
Article
CAS
Google Scholar
Tarnopolsky LJ, MacDougall JD, Atkinson SA, Tarnopolsky MA, Sutton JR. Gender differences in substrate for endurance exercise. J Appl Physiol. 1990;68:302–8.
Article
CAS
Google Scholar
Riddell MC, Bar-Or O, Wilk B, Parolin ML, Heigenhauser GJ. Substrate utilization during exercise with glucose and glucose plus fructose ingestion in boys ages 10--14 yr. J Appl Physiol. 2001;90:903–11.
Article
CAS
Google Scholar
Venables MC, Achten J, Jeukendrup AE. Determinants of fat oxidation during exercise in healthy men and women: a cross-sectional study. J Appl Physiol. 2005;98:160–7.
Article
Google Scholar
Goodpaster BH, Wolfe RR, Kelley DE. Effects of obesity on substrate utilization during exercise. Obes Res. 2002;10:575–84.
Article
CAS
Google Scholar
Stephens BR, Cole AS, Mahon AD. The influence of biological maturation on fat and carbohydrate metabolism during exercise in males. Int J Sport Nutr Exerc Metab. 2006;16:166–79.
Article
CAS
Google Scholar
Timmons BW, Bar-Or O, Riddell MC. Influence of age and pubertal status on substrate utilization during exercise with and without carbohydrate intake in healthy boys. Appl Physiol Nutr Metab. 2007;32:416–25.
Article
CAS
Google Scholar
Brun J-F, Romain A-J, Mercier J. Maximal lipid oxidation during exercise (Lipoxmax): from physiological measurements to clinical applications. Facts Uncertainties Sci Sports. 2011;26:57–71.
Article
Google Scholar
Nguyen T, Ploeger HE, Obeid J, Issenman RM, Baker JM, Takken T, et al. Reduced fat oxidation rates during submaximal exercise in adolescents with Crohn’s disease. Inflamm Bowel Dis. 2013;19:2659–65.
Article
Google Scholar
Wallace CA, Giannini EH, Huang B, Itert L, Ruperto N, Childhood arthritis rheumatology research Alliance, et al. American College of Rheumatology provisional criteria for defining clinical inactive disease in select categories of juvenile idiopathic arthritis. Arthritis Care Res (Hoboken). 2011;63:929–36.
Article
Google Scholar
Riddell MC, Jamnik VK, Iscoe KE, Timmons BW, Gledhill N. Fat oxidation rate and the exercise intensity that elicits maximal fat oxidation decreases with pubertal status in young male subjects. J Appl Physiol. 2008;105:742–8.
Article
CAS
Google Scholar
Frayn KN. Calculation of substrate oxidation rates in vivo from gaseous exchange. J Appl Physiol Respir Environ Exerc Physiol. 1983;55:628–34.
CAS
PubMed
Google Scholar
Achten J, Gleeson M, Jeukendrup AE. Determination of the exercise intensity that elicits maximal fat oxidation. Med Sci Sports Exerc. 2002;34:92–7.
Article
Google Scholar
Péronnet F, Massicotte D. Table of nonprotein respiratory quotient: an update. Can J Sport Sci. 1991;16:23–9.
PubMed
Google Scholar
Rochette E, Bourdier P, Pereira B, Echaubard S, Borderon C, Caron N, et al. Impaired muscular fat metabolism in juvenile idiopathic arthritis in inactive disease. Front Physiol. 2019;10:528.
Article
Google Scholar
Smith RL, Soeters MR, Wüst RCI, Houtkooper RH. Metabolic flexibility as an adaptation to energy resources and requirements in health and disease. Endocr Rev. 2018;39(4):489–517.
Article
Google Scholar
Ranallo RF, Rhodes EC. Lipid metabolism during exercise. Sports Med. 1998;26:29–42.
Article
CAS
Google Scholar
Yeh K-W, Lee C-M, Chang C-J, Lin Y-J, Huang J-L. Lipid profiles alter from pro-atherogenic into less atherogenic and proinflammatory in juvenile idiopathic arthritis patients responding to anti TNF-α treatment. PLoS One. 2014;9:e90757.
Article
Google Scholar
Li YP, Reid MB. Effect of tumor necrosis factor-alpha on skeletal muscle metabolism. Curr Opin Rheumatol. 2001;13:483–7.
Article
CAS
Google Scholar
Carnagarin R, Dharmarajan AM, Dass CR. Molecular aspects of glucose homeostasis in skeletal muscle--a focus on the molecular mechanisms of insulin resistance. Mol Cell Endocrinol. 2015;417:52–62.
Article
CAS
Google Scholar
Wellen KE, Hotamisligil GS. Inflammation, stress, and diabetes. J Clin Invest. 2005;115:1111–9.
Article
CAS
Google Scholar
Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science. 1996;271:665–8.
Article
CAS
Google Scholar
Capeau J. Insulin signaling: mechanisms altered in insulin resistance. Med Sci (Paris). 2003;19:834–9.
Article
Google Scholar
Burska AN, Sakthiswary R, Sattar N. Effects of tumour necrosis factor antagonists on insulin sensitivity/resistance in rheumatoid arthritis: a systematic review and meta-analysis. PLoS One. 2015;10:e0128889.
Article
Google Scholar
Tse MCL, Herlea-Pana O, Brobst D, Yang X, Wood J, Hu X, et al. Tumor necrosis factor-α promotes phosphoinositide 3-kinase enhancer a and AMP-activated protein kinase interaction to suppress lipid oxidation in skeletal muscle. Diabetes. 2017;66:1858–70.
Article
CAS
Google Scholar
Goodpaster BH, Katsiaras A, Kelley DE. Enhanced fat oxidation through physical activity is associated with improvements in insulin sensitivity in obesity. Diabetes. 2003;52:2191–7.
Article
CAS
Google Scholar
Bohr A-H, Nielsen S, Müller K, Karup Pedersen F, Andersen LB. Reduced physical activity in children and adolescents with juvenile idiopathic arthritis despite satisfactory control of inflammation. Pediatr Rheumatol Online J. 2015;13:57.
Article
Google Scholar
Bos GJFJ, Lelieveld OTHM, Armbrust W, Sauer PJJ, Geertzen JHB, Dijkstra PU. Physical activity in children with Juvenile Idiopathic Arthritis compared to controls. Pediatr Rheumatol Online J. 2016;14 [cited 2018 Apr 30]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936199/
Dyck DJ. Adipokines as regulators of muscle metabolism and insulin sensitivity. Appl Physiol Nutr Metab. 2009;34:396–402.
Article
CAS
Google Scholar
Markula-Patjas KP, Ivaska KK, Pekkinen M, Andersson S, Moilanen E, Viljakainen HT, et al. High adiposity and serum leptin accompanied by altered bone turnover markers in severe juvenile idiopathic arthritis. J Rheumatol. 2014;41:2474–81.
Article
Google Scholar
Venables MC, Jeukendrup AE. Endurance training and obesity: effect on substrate metabolism and insulin sensitivity. Med Sci Sports Exerc. 2008;40:495–502.
Article
CAS
Google Scholar