- Poster presentation
- Open Access
Granuloma-in-follicles in pediatric Crohn’s disease
© Janssen et al; licensee BioMed Central Ltd. 2011
- Published: 14 September 2011
- Giant Cell
- Diagnostic Feature
- Cytokine Profile
- Multinucleated Giant Cell
- Cellular Composition
SNPs in NOD2 are a major susceptibility factor for Crohn’s disease (CD). (Sub)mucosal granulomas are a diagnostic feature of CD.
To better describe morphological and immunohistochemical featurs of pediatric CD (pCD) granulomas.
In addition to small isolated (sub)mucosal granulomas, we found granulomas in the follicle(GIF) centre of mucosa-associated lymphoid tissue, visualized by CD20 staining (fig). GIF were found in half the number of procedures (more often in chirurgical than in endoscopic) in only 7 out of 17 pCD patients. Exceptional lymphocyte emperipolesis in multinucleated giant cells (MGCs) and IL-17 expression were observed, only in granulomas of pCD with GIF (fig). The granulomas of patients with GIF often had a lymphocytic corona, but polycyclic granuloma architecture was rare. No clear relation was seen between the presence of GIF and the CD-associated NOD2, ATG1 and ATG16L1 genotypes.
We defined GIF as a morphological characteristic in few selected pCD patients, and demonstrate association with emperipolesis of lymphocytes in MGCs and weak IL17 expression.
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.