- Poster presentation
- Open Access
The analysis of specific antinuclear antibodies concentrations in children with connective tissue diseases
© Klochkova et al; licensee BioMed Central Ltd. 2011
- Published: 14 September 2011
- Rheumatoid Arthritis
- Systemic Lupus Erythematosis
- Severe Form
- Positive Case
Total antinuclear antibodies (ANA) are widely detected in pediatric rheumatology, while the data about specific ANA are few and controversial.
To evaluate the levels of ds-DNA, Sm, anti-Ro, anti-Jo1, Scl-70 antibodies in serum of children with connective tissue diseases (CTDs). To look for correlations between clinical features of the CTDs, age and gender of children and specific ANA concentrations.
We observed 187 children from 2 to 18 years (median 13 years, 25‰ – 9 years, 75‰ – 15 years); 70 (37,4%) boys, 117 (62,6%) – girls with systemic lupus erythematosis (SLE), juvenile rheumatoid arthritis (JRA), spondyloarthritis (SA), scleroderma (systemic/localized), dermatomyosites and mixed CTD (MCTD). All patients undergo common rheumatologic examination. Specific ANA were measured with Elia method on ImmunoCAP 250 (Phadia).
Number of positive results
Negative results (median concentration; 25‰; 75‰)
19 (10,1%) (17 SLE, 1 JRA, 1 scleroderma)
1 (0,4;2) (IU/ml)
4 (2%) (4 SLE)
0,1 (0;0,3) (U/ml)
13 (7%) (10 SLE, 2 MCTD, 1 systemic scleroderma)
0,1 (0;0,3) (U/ml)
2 (1%) (2 MCTD)
0 (0; 0,1) (U/ml)
0 (0;0,1) (U/ml)
Ds-DNA, Sm, anti-Ro, anti-Jo1 were found predominantly in girls with SLE. The levels of antibodies didn’t correlate with age and duration of the disease. Evaluation of Scl-70 was not indicative for systemic or localized scleroderma. Further observations are necessary to evaluate the prognostic value of measured specific ANA in these children.
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