Influence of TNFα–308 and T676G TNF-RII polymorphism on response to etanercept and posibility to discontinue tretment
© Vojinovic et al; licensee BioMed Central Ltd. 2011
Published: 14 September 2011
Genetic contribution of TNFὰ–308 promoter and T676G TNF-RII polymorphism on response to TNF-blocking agents in JIA is not yet well established.
Genomic DNA was extracted and TNFὰ–308 promoter and T676G TNF-RII polymorphism was evaluated using the PCR-RFLP method in 60 JIA patients treated with etanercept. Time cut of point for outcome data analysis was 4 years.
JIA patients with GG TNFὰ308 genotype can achieve better outcome and etanercept treatment can be stopped earlier compared to GA genotype patients who need two years of treatment to achieve same results. TNFὰ308 genotype could be useful clinical predictive biomarker for treatment response in all disease subtypes except systemic and RF positive JIA.
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