- Poster presentation
- Open Access
Infantile de novo primary antiphospholipid syndrome revealed by neonatal stroke
https://doi.org/10.1186/1546-0096-9-S1-P263
© Merlin et al; licensee BioMed Central Ltd. 2011
- Published: 14 September 2011
Keywords
- Middle Cerebral Artery
- Antithrombin
- Maternal Serum
- Clonic Seizure
- Maternal Status
Ba
Antiphospholipid antibody syndrome (APS) is a rare condition in childhood. Some cases have been reported in neonates, and it is believed that most of them result from a transplacental transfer of antiphospholipid antibodies (APLA) from the mother to the foetus.
Case
Biological features of the child and the mother
Time after birth | ||||||
---|---|---|---|---|---|---|
5 days | 1 year | |||||
Normal values | Child | Mother | Child | Mother | ||
KCT (sec) | 43/34 | 52/35 | 36/36 | |||
Anticardiolipid AB | IgM (UMPL/ml) | <10 | <5 | <1 | 4 | <1 |
IgG (UGPL/ml) | <11 | <5 | <1 | 191 | <1 | |
Anti β2gpI AB | IgM | <10 | <5 | <1 | <1 | <1 |
IgG | <20 | <5 | <1 | 258 | <1 | |
VDRL | - | - | NEG | NEG | ||
TPHA | - | NEG | NEG |
Conclusion
Contrary to what is usually thought, neonatal APS not always result from the transplacental transfer of APLA. Our case highlights the importance of considering the maternal status when reporting on neonatal APS; and of considering the possibly of APS even in the absence of antibodies in the mother.
Authors’ Affiliations
Copyright
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.