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Superior efficacy of Adalimumab in treating childhood refractory chronic uveitis when used as first biologic

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Background

We previously reported that Adalimumab is more efficacious than Infliximab in maintaining remission of chronic childhood uveitis.

Aim

To compare the efficacy of Adalimumab when used as first anti-TNFα therapy versus Adalimumab used after the failure of a previous anti-TNFα (Infliximab). Open-label, comparative, multi-centre, cohort study of childhood non-infectious chronic uveitis.

Methods

26 patients (14 F, 12 M; median age: 8.6 years) with refractory, vision threatening, non-infectious active uveitis were enrolled. Due to the refractory course of uveitis to previous DMARD treatment, Group 1 received Adalimumab (24 mg/sq mt, every 2 weeks), as first anti-TNFα choice; Group 2 received Adalimumab, as second anti-TNFα drug, due to the loss of efficacy of Infliximab, after a period of at least 1 year (5 mg/kg at weeks 0, 2, 6 and then every 6–8 weeks). Both groups received Adalimumab for at least 1 year of treatment. Primary outcome was, once remission was achieved, the time to a first relapse. Time to achieve remission, and time to systemic corticosteroid discontinuation were also considered.

Results

14 children (10 with JIA, 3 with idiopathic uveitis, 1 with Behçet’s disease) were recruited in Group 1; 12 children (7 with JIA, 3 with idiopathic uveitis, 1 with early-onset sarcoidosis, 1 with Behçet’s disease) in Group 2. Cox-regression analysis did not show statistical significant differences between the two groups with regard to time to achieve remission, whilst Group 2 needed a longer time to discontinuation steroid (median ±SE: 7 ±1.7 vs 3 ±0.9 months, CI 95%: 3.6-10.4 vs 1.1-4.8, p<0.001) and a lower probability to steroid discontinuation during the first 12 months of treatment (Mantel-Cox χ2 4.12, p<0.041). In long-term follow-up, Group 1 had higher probability of uveitis remission (time to first flare) than Group 2 during the time of treatment on Adalimumab (median ±SE: 18 ±1.1 vs 4 ±0.6 months, CI 95%: 15.6-27.5 vs 2.7-5.2, Mantel-Cox χ2 10.1, p<0.002) (Figure 1).

figure1

Figure 1

Conclusions

Even if limited to a relatively small group, our study suggests a better efficacy of Adalimumab when used as first anti-TNFα treatment in chronic childhood uveitis.

Author information

Correspondence to G Simonini.

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This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Simonini, G., Taddio, A., Cattalini, M. et al. Superior efficacy of Adalimumab in treating childhood refractory chronic uveitis when used as first biologic. Pediatr Rheumatol 9, P220 (2011) doi:10.1186/1546-0096-9-S1-P220

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Keywords

  • Infliximab
  • Sarcoidosis
  • Uveitis
  • Adalimumab
  • DMARD Treatment