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MyastheniaGravis(MG) in a patient with Juvenile Idiopathic Arthritis
Pediatric Rheumatology volume 9, Article number: P185 (2011)
We present a 17year old girl known with Rheumatoid Factor Positive Polyarticular Juvenile Idiopathic Arthritis for 4 years who developed Myasthenia Gravis while on therapy with Methotrexate, Prednisone and Ibuprofen.
This patient presented to the emergency room with a respiratory infection. She had been feeling weak and had noticed tongue weakness and difficulty swallowing, which had worsened significantly since the respiratory infection.
On examination she was found to have clinical signs of Right Middle Lobe pneumonia and was found to be weak, especially in her proximal muscle groups. She had bilateral ptosis as well as facial weakness. She had active arthritis in multiple joints. Despite intravenous antibiotics and full supportive management she deteriorated rapidly, and within 12 hours required intubation and ventilation.
The patient was found to have high ACH receptor antibodies and responded dramatically to pyridostygmine therapy, confirming the diagnosis of MG. High prednisone and azathioprine have been added to her regime.
Myasthenia Gravis is a rare association with JIA. The majority of cases appear to be associated with oligo-articular JIA. This patient presented after an acute infection and a recent worsening in her JIA symptoms.
Gowing EC, McKown KM: Myasthenia gravis in a patient with pauciarticular juvenile chronic arthritis. J Clin Rheumatol. 2002, 8 (5): 269-72. 10.1097/00124743-200210000-00008.
Bhettay EM, Kalla AA: Coexistence of myasthenia gravis and seropositive juvenile chronic arthritis. Clin Exp Rheumatol. 1992, 10 (5): 499-501.
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Scott, C., Kalla, A. MyastheniaGravis(MG) in a patient with Juvenile Idiopathic Arthritis. Pediatr Rheumatol 9, P185 (2011) doi:10.1186/1546-0096-9-S1-P185
- Juvenile Idiopathic Arthritis
- Middle Lobe