Switching to an alternative biological agent in juvenile idiopathic arthritis (II)
- S Murias,
- A Remesal,
- L Latorre,
- M Gomez and
- R Merino
© Murias et al; licensee BioMed Central Ltd. 2011
Published: 14 September 2011
Juvenile idiopathic arthritis (JIA) is a heterogeneous disease, and it’s associated with an increased use of various biological agents in recent years.
Evaluate clinical response to current biological agent in JIA patients.
This is a retrospective study of 109 JIA patients from a tertiary centre (see poster 1). Variables included were: current biological treatment (both the first agent used as the second, third or fourth when it had been switched) and duration of treatment (years with a new agent or since reintroduction of an agent used before) plus physician visual analogue scale (ph-VAS), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) at baseline and at the end of the study. Concomitant therapy with methotrexate (MTX) was also recorded.
Duration of treatment with the current biological agent was 1.2 ± 1 (0.1- 4.9) median 0.8 years. This agent was etanercept (ETA) in 58 cases, adalimumab (ADA) in 16, tocilizumab (TCZ) in 11, anakinra (AK) in 9 and infliximab (IFX) in 2. Thirteen patients were off treatment with biological agents, 12 due to inactive disease and one because of inefficacy.
Analytical and clinical response to current biological agent
The results indicate that reintroduction of a previously effective biological agent may be successful; besides, switching to a second, third or even fourth biological agent in those patients whose disease remains active, can be effective as well.
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