- Poster presentation
- Open Access
Determing an “autoimmune” phenotype in systemic JIA
© Fischer et al; licensee BioMed Central Ltd. 2011
- Published: 14 September 2011
- Public Health
- Retrospective Analysis
- Juvenile Idiopathic Arthritis
- Phenotypic Characteristic
Data from research, clinics and response to treatment point out to an autoinflammatory pathogenesis in Systemic onset Juvenile Idiopathic Arthritis (SoJIA). However a subgroup of patients present with c hronic a ctive course of disease, destructive p olyarthritis and production of a utoantibodies (CAPA-subtype) not responsive to anti IL-1 treatment.
Determine phenotypic characteristics of the CAPA-subtype of SoJIA.
Retrospective analysis in a cohort of 35 SoJIA patients well characterized according clinical course and ANA, Rheumatic factor and ANCA.
mean 69 (range 1-262)
percentage for each group
onset age (years)
joints at onset
joints when AK pos
2 of 4
8 of 12
There is evidence for an autoimmune course of disease in SoJIA in a subset of patients with chronic polyarthritis but without relapses of autoinflammation. These patients probably will need a switch in treatment to prevent further joint destruction.
supported by the BMBF (AID-Net 01GM0907)
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.