Skip to main content
  • Poster presentation
  • Open access
  • Published:

QT dispersion and cardiac involvement in patients with juvenile idiopathic arthritis

Background and aim

Juvenile idiopathic arthritis (JIA) is the commonest cause of chronic inflammatory arthritis in childhood. Cardiac involvement as pericarditis, myocarditis and valvular disease is known to occur in patients with JIA (JIA), as it does in adults with rheumatoid arthritis. There are, however, few descriptions concerning systolic and diastolic functions of the left ventricle (LV) in children with JIA. QT dispersion (QTd) is simple noninvasive arrhythmogenic marker, that can be used to assess homogeneity of cardiac repolarization, have not been studied in JIA patients before. A recent study found that rheumatoid arthritis patients had an abnormally longer QTd and corrected QT (cQTd) dispersion, markers for ventricular arrhythmogenicity. The study was to assess QTd and cQTd, their relation with systolic and diastolic function of the LV in a group of children with JIA.


We performed electrocardiography and Doppler echocardiography on 50 patients with JIA and 70 healthy children. Maximum QT (QTmax), minimum QT (QTmin), QTd, corrected QT, maximum corrected QT (cQTmax), minimum corrected QT (cQTmin) and cQTd intervals were measured from standard 12-lead electrocardiography.


No statistically significant differences were found between the groups in QTd and cQTd. (Table 1) Among the diastolic parameters, increased late flow velocity, decreased early flow velocity and prolonged isovolumic relaxation time reflected an abnormal relaxation form of diastolic dysfunction. During 12 months of follow-up, no ventricular arrhythmias were documented in either group.

Table 1 Electrocardiographic measurements of the JIA patients and controls


In this study, QTd and cQTd was not found to be longer in JIA patients than healthy children. Larger scale, prospective, longitudinal studies are needed to assess the effect of prolonged QTd and inflammatory activity on the risk of malign ventricular arrhythmia.


Rights and permissions

Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and permissions

About this article

Cite this article

Koca, B., Kasapcopur, O., Bakari, S. et al. QT dispersion and cardiac involvement in patients with juvenile idiopathic arthritis. Pediatr Rheumatol 9 (Suppl 1), P141 (2011).

Download citation

  • Published:

  • DOI: