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The using of arthroscopy and synovial biopsy in chronic knee monoarthritis in children

The knee damage in children may be a sign of many diseases. They include bone and joint infections, neoplastic disorders, trauma and arthritis.

The aim of our study was to detect diseases which coursing with knee damage and to reveal arthroscopic and synovial histological changes.

We included in our study 29 children with chronic knee monoarthritis (CKMA), 15 girls and 14 boys with duration knee monoarthritis symptoms > 6 weeks. Most of the patients were examined with arthrosonography and MRI. Arthroscopy with synovial biopsy was performed on 10 children (2 with tuberculosis infection and 8 with CKMA unknown origin).

Five CKMA boys transformed in juvenile spondiloarthropathy (3 had psoriatic arthritis). Juvenile rheumatoid arthritis was diagnosed in 6 children (4 F: 2 M), all girls were ANA-positive and developed oligoarthritis and one also had uveitis. There were 3 cases of tuberculosis arthritis without primary lung damage. Another cases included knee osteoarthritis, Borrellia burgdorfery infection, angiodysplasia of knee, posttraumatic arthritis with meniscus damage, osteochondritis dissecans and Hoffa disease. The largest group consisted of children with chronic villous proliferate synovitis (6 F: 2 M) unknown origin was revealed by arthroscopy and synovial biopsy. Chlamydia infection was detected in synovial fluid and membrane in 2 children.

Synovial histology was determined as focal hypertrophy of synovial membrane with mononuclear cell infiltration in half patients as signs of neoangiogenesis in another part. This form of CKMA was torpid.

CKMA is very geterogenous; some of them need in arthroscopy with synovial biopsy.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Chicova, I., Avramenko, V. & Kostik, M. The using of arthroscopy and synovial biopsy in chronic knee monoarthritis in children. Pediatr Rheumatol 6 (Suppl 1), P82 (2008).

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