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Clinical significance of anti-cyclic citrullinated peptide antibodies in patients with juvenile rheumatoid arthritis

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Anti-cyclic citrullinated peptide antibodies (anti-CCP Abs) are considered to be specific for rheumatoid arthritis (RA), but there are few data on anti-CCP Abs and its relationship with the disease activity in patients with juvenile rheumatoid arthritis (JRA). The aim of this study was to explore the sensitivity and specificity of anti-CCP Abs in JRA.

Materials and methods

Serum samples obtained from 37 JRA patients (33 girls and 4 boys, with a mean age of 12.31 ± 3.29 years) and 20 healthy controls (matched for age and sex ratio with JRA patients) were assayed for anti-CCP Abs using ELISA method. The relationship between anti-CCP Abs and disease activity were also analyzed.


Prevalence of anti-CCP Abs was 8.1% (3/37) in JRA patients. In 20 normal subjects, no one was found anti-CCP Abs positive. The sensitivity of anti-CCP Abs was 8.1%, the specificity was 100%. Disease activity score (DAS28) showed no significant difference between anti-CCP Abs-positive group and anti-CCP Abs-negative group.


Prevalence of anti-CCP Abs was very low in patients with JIA. It was not very helpful for diagnosis of JIA and estimating its disease activity. Therefore it is not necessary for anti-CCP Abs be tested routinely in patients with JIA.

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Correspondence to Li Bo.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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About this article


  • Public Health
  • Peptide
  • Rheumatoid Arthritis
  • Arthritis
  • Clinical Significance