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The role of antibodies to mutated citrulinated vimentin (anti-MCV) in juvenile idiopathic arthritis patients

Background

Anti-MCV antibodies (Ab) have high sensitivity and prognostic value in patients with RA. We attempt to correlate positive anti-MCV Ab in different subtypes of JIA patients with six core outcome variables.

Patients and methods

Anti-MCV Ab and Anti-CCP Ab were tested by ELISA (Orgentec, Germany) in sera from 57 JIA, and 14 control patients (12 patients with SLE, 1 with MCTD and 1 with synovial cyst). (16 boys, 41 girls), The mean age was 11,2 years (range 2,5–18,0), and mean disease duration was 3, 4 years (SD ± 2.9). Cut off value ≥ 20 U/mL was considered positive.

Results

Positive anti-MCV Ab were detected in only 3/58 (5,2%) JIA patients, and were significantly elevated in two RF positive polyartritis patients, and slightly elevated in 1/19 (5,3%) patients with enthesitis-related arthritis (ErA). Among all patients, anti-CCP Ab were positive only in one anti-MCV positive polyarticular JIA patient. Anti-MCV and RF positivity correlated statistically (r = 0,504, P = 0,028) in ErA, while no association between anti-MCV Ab and six core outcome variables was observed in this, or other JIA subtypes. Unexpectedly, anti-MCV was detected in 3/12 (25%) SLE patients (2 low positive and 1 significantly positive), and in 1 patient with MCTD. All of these patients were both RF and anti-CCP negative.

Conclusion

In contrast to RA, anti-MCV antibodies are not specific for JIA. However, within JIA patients, significantly elevated levels are almost exclusively found in two RF positive, polyarticular patients.

References

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    Innala L, Kokkonen H, Eriksson C, Jidell E, Berglin E, Dahlqvst SR: Antibodies Against Mutated Citrullinated Vimentin Are a Better Predictor of Disease Activity at 24 Months in Early Rheumatoid Arthritis Than Antibodies Against Cyclic Citrullinated Peptides. J Rheumatol. 2008 Apr 1,

  2. 2.

    Mathsson L, Mullazehi M, Wick MC, Sjöberg O: Antibodies against citrullinated vimentin in rheumatoid arthritis: higher sensitivity and extended prognostic value concerning future radiographic progression as compared with antibodies against cyclic citrullinated peptides. Arthritis Rheum. 2008, 58 (1): 36-45. 10.1002/art.23188.

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Author information

Correspondence to L Lamot.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Keywords

  • Public Health
  • Arthritis
  • Outcome Variable
  • Elevated Level
  • Disease Duration