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  • Open Access

Anti-cyclic citrullinated peptide: its prevalence and clinical significance in a South African cohort with juvenile idiopathic arthritis

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Pediatric Rheumatology20086 (Suppl 1) :P61

  • Published:


  • Rheumatoid Arthritis
  • Juvenile Idiopathic Arthritis
  • Serological Marker
  • Total Cohort
  • Paediatric Rheumatology


Anti-cyclic citrullinated peptide (anti-CCP) antibodies are a highly specific serological marker for adult-onset rheumatoid arthritis, present early in the course of the disease, and are a marker of erosive disease.


To assess the prevalence and clinical significance of anti-CCP antibodies in a cohort of children with juvenile idiopathic arthritis (JIA).


A retrospective review of the records of children with JIA attending a paediatric rheumatology clinic at Chris Hani Baragwanath Hospital was undertaken. Anti-CCP antibodies were tested using an enzyme linked immunoabsorbent assay (EliACCP).


Records of 52 patients (54% males, 46% females) were reviewed. The mean (SD) age and follow-up period were 10.69 (3.81) and 2.3 (1.7) years, respectively. The majority of the children (83%) were Black. The subtypes of JIA were as follows: systemic 21%, polyarticular 50%, oligoarticular 19%, enthesitis-related arthritis 2%, psoriatic 2% and other 6%. Anti-CCP antibodies were present in the sera of 8 of 28 patients tested (29%). They were detected exclusively in patients with the polyarticular subtype of JIA. IgM RF was positive in 14 (29.17%) of the total cohort, but not exclusively in patients with the polyarticular subtype of JIA. The overall concordance between the 2 tests was fair (Kappa statistic = 0.39).


Anti-CCP antibodies are present in a high proportion of patients with JIA, and in the polyarticular JIA subtype. They appear to be a better marker of this subtype than IgM RF. The concordance between anti-CCP antibodies and IgM RF in our patients with JIA is fair.

Authors’ Affiliations

Chris Hani Baragwanth Hospital, Johanessburg, Gauteng province, South Africa
University of Witwatersrand, Johanessburg, Gauteng province, South Africa


© Mistry et al; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.