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  • Poster presentation
  • Open Access

HLA-B27 predicts a more extended disease with increasing age at onset in boys with juvenile idiopathic arthritis

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Pediatric Rheumatology20086 (Suppl 1) :P57

  • Published:


  • Public Health
  • High Risk
  • Arthritis
  • Regression Analysis
  • Clinical Manifestation


The cell-surface antigen HLA-B27 is well known to be associated with spondylarthopathies, reactive arthritis and enthesitis. HLA-B27 plays an important role in the ILAR classification of JIA.

Materials and methods

We wanted to investigate the associations of HLA-B27 on the clinical manifestation of juvenile idiopathic arthritis, during the first three years of disease, in a study as close to a population-based one as possible. Clinical and serological data were collected in 305 patients.


HLA-B27 was analysed positive in 25.5% of the patients and we found a higher proportion of HLA-B27 positive boys with older age at onset (p = 0.034). Regression analysis showed a correlation of 0.7 in the HLA-B27 positive boys, pointing to a higher risk of more joints to be involved with a higher age at onset. Using Fisher's exact test, involvement of small joints in the lower extremities was associated with HLA-B27 in boys (p = 0.011), but not in girls (p = 0.687).


HLA-B27 is of increasing importance with higher age at onset in boys with JIA, predicting more active joints within the first three years of disease, and also involving small joints in the lower extremity to a higher degree than in HLA-B27 negative boys.

Authors’ Affiliations

Department of Women's and Children's Health, Uppsala University Children's Hospital, Uppsala, Sweden
Department of Pediatrics, Falun Hospital, Falun, Sweden
Department of Pediatrics, Ryhov County Hospital, Jönköping, Sweden
Department of Pediatrics, Århus University Hospital, Skejby, Denmark
University Clinic of Pediatrics II, Rigshospitalet, Copenhagen, Denmark
Institute of Clinical Medicine/Institute of Community Medicine, University of Tromsø, and Department of Pediatrics, University Hospital of North Norway, Tromsø, Norway
Department of Laboratory Medicine, Children's and Women's Health, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway and Department of Pediatrics, St. Olavs Hospita, Trondheim, Norway
Department of Pediatrics, Göteborg University, Göteborg, Sweden


© Berntson et al; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.