Skip to main content

Advertisement

HLA-B27 predicts a more extended disease with increasing age at onset in boys with juvenile idiopathic arthritis

Article metrics

  • 1596 Accesses

  • 1 Citations

Background

The cell-surface antigen HLA-B27 is well known to be associated with spondylarthopathies, reactive arthritis and enthesitis. HLA-B27 plays an important role in the ILAR classification of JIA.

Materials and methods

We wanted to investigate the associations of HLA-B27 on the clinical manifestation of juvenile idiopathic arthritis, during the first three years of disease, in a study as close to a population-based one as possible. Clinical and serological data were collected in 305 patients.

Results

HLA-B27 was analysed positive in 25.5% of the patients and we found a higher proportion of HLA-B27 positive boys with older age at onset (p = 0.034). Regression analysis showed a correlation of 0.7 in the HLA-B27 positive boys, pointing to a higher risk of more joints to be involved with a higher age at onset. Using Fisher's exact test, involvement of small joints in the lower extremities was associated with HLA-B27 in boys (p = 0.011), but not in girls (p = 0.687).

Conclusion

HLA-B27 is of increasing importance with higher age at onset in boys with JIA, predicting more active joints within the first three years of disease, and also involving small joints in the lower extremity to a higher degree than in HLA-B27 negative boys.

Author information

Correspondence to L Berntson.

Rights and permissions

Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and Permissions

About this article

Cite this article

Berntson, L., Damgård, M., Andersson-Gäre, B. et al. HLA-B27 predicts a more extended disease with increasing age at onset in boys with juvenile idiopathic arthritis. Pediatr Rheumatol 6, P57 (2008) doi:10.1186/1546-0096-6-S1-P57

Download citation

Keywords

  • Public Health
  • High Risk
  • Arthritis
  • Regression Analysis
  • Clinical Manifestation