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Juvenile Psoriatic Arthritis (JPsA) clinical features and outcome of 119 patients
Pediatric Rheumatology volume 6, Article number: P42 (2008)
To determine the long-term outcome of a single center cohort of children with JPsA.
Clinical records of 122 patients meeting the Vancouver or ILAR criteria for JPsA were reviewed. Patients were divided into 4 groups depending on their clinical features: a)Oligoarticular, b)RF(-) polyarticular, c)RF(+) polyarticular and d)enthesitis related arthritis (ERA). Patient characteristics and clinical features at onset and during follow-up were determined.
The cohort consisted of 119 patients, 59(49.6%) had polyarticular course, 54(47.8%) were RF(-) and 4(3.3%) RF(+), 44 patients(38.3%) had oligoarticular course and 16(13.4%) ERA.
At diagnosis patients with ERA were older as compared to patients with oligoarticular and polyarticular course (11.6 ± 2.2 years vs 7.7 ± 4.3 years and 7.1 ± 4.5 years respectively p = 0.001).
Patients with polyarticular course had more MCP, PIP and wrist involvement when compared to patients with oligoarticular course and with ERA (p < 0.001 for all).
Patients with ERA had significantly more hip and sacroiliac involvement compared to the other groups (p < 0.001 for both).
Nail changes was seen in 66 patients (57%) and was associated with DIP involvement at presentation (p = 0.0034).
Time to first inactive disease period on but not off therapy was significantly longer among patients with polyarticular disease when compared to the oligoarticular and the ERA groups (p = 0.016 and p = 0.48 respectively).
Patients with polyarticular had more contracture during follow-up when compared to patients with oligoarticular and with ERA (p = 0.01)
Patients with JPsA compromised from three distinct group of patients.
Most patients with JPsA will achieve inactive disease and only minority will have long lasting contracture.
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Aviel, Y.B., Tyrrell, P., Feldman, B. et al. Juvenile Psoriatic Arthritis (JPsA) clinical features and outcome of 119 patients. Pediatr Rheumatol 6, P42 (2008). https://doi.org/10.1186/1546-0096-6-S1-P42
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- Distinct Group
- Single Center
- ILAR Criterion