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Anti-tumour necrosis factor (anti-TNF) in the treatment of juvenile idiopathic arthritis-associated uveitis

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Introduction

Chronic uveitis is associated with JIA in about 15–30% of cases. Treatment with anti-TNF agents is very effective in JIA, but their efficacy for uveitis is controversial. We present here the preliminary results of a retrospective case series of uveitis associated of JIA and treated by different anti-TNF.

Objective

To evaluate the efficacy of TNF inhibitors in JIA-associated uveitis, as well as report the cases of uveitis associated with the use of anti-TNF.

Methods

The data of 16 patients with JIA and uveitis receiving anti-TNF were collected retrospectively in three French centers.

Results

Of the 16 patients, 10 were treated with etanercept (62.5%), 1 with adalimumab (6.25%), and 5 (31.2%) with infliximab. Notably, two cases of uveitis were associated with use of etanercept. In 5 patients (31.2%) the anti-TNF was changed because of lack of efficacy and/or side effects to another one (in 4/5 adalimumab). Ten patients had a complicated uveitis (cataract in 5). The number of relapses of uveitis was 4 ± 1.35 with the first anti-TNF, and 1.3 ± 1.5 with the second one. Remission of uveitis was obtained in 4 cases, 3 of them with adalimumab and one case with etanercept.

Conclusion

Anti-TNF agents have a favourable effect in JIA-associated uveitis, but adalimumab and perhaps infliximab may be more effective than etanercept, during which treatment uveitis may even develop.

Author information

Correspondence to C Rivarola.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Rivarola, C., Hovhannessian, C., Duquesne, A. et al. Anti-tumour necrosis factor (anti-TNF) in the treatment of juvenile idiopathic arthritis-associated uveitis. Pediatr Rheumatol 6, P36 (2008) doi:10.1186/1546-0096-6-S1-P36

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Keywords

  • Public Health
  • Infliximab
  • Cataract
  • Etanercept
  • Uveitis