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  • Open Access

Rituximab is a therapeutical option for juvenile microscopic polyangiitis

  • 1,
  • 2,
  • 1,
  • 1,
  • 1,
  • 1,
  • 3 and
  • 1
Pediatric Rheumatology20086 (Suppl 1) :P268

https://doi.org/10.1186/1546-0096-6-S1-P268

  • Published:

Keywords

  • Rheumatoid Arthritis
  • Lymphoma
  • Systemic Lupus Erythematosus
  • Cyclophosphamide
  • Vasculitis

Introduction

Microscopic polyangitiis is characterized by anti-neutrophil cytoplasmic antibodies (ANCA) and small vessel vasculitis. The diseases usually respond to cyclophosphamide (Cyc) but some patients are therapy resistant. Rituximab (RIT) is a chimeric antibody to CD20 causing lysis of B-lymphocytes and used for treatment of lymphomas. RIT has also been successfully used in patients with rheumatoid arthritis (RA), idiopathic thromobocytopaenic purpura, autoimmune haemolytic anaemia, cold agglutinin disease, systemic lupus erythematosus and vasculitides.

Case report

A 16-year old female patient with hemoptysis, nephritis, dermatitis was diagnosed as a myeloperoxidase-ANCApositive microscopic polyangiitis. The patient was resistant to conventional therapy or had relapsed repeatedly after cessation of cyclophosphamide (Cyc). The patient was treated with intravenous infusions of rituximab (RIT).

Conclusion

RIT seems promising and safe in pediatric microscopic polyangiitis. Controlled studies should be conducted.

Authors’ Affiliations

(1)
Department of Pediatrics, Innsbruck Medical University, Innsbruck, Austria
(2)
Department of Radiology, Innsbruck Medical University, Innsbruck, Austria
(3)
Department of Nephrology, Innsbruck Medical University, Innsbruck, Austria

Copyright

© Brunner et al; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.

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