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Kawasaki disease in Sicily: a 7 year survey


Scant reports concerning Kawasaki Disease (KD) in Sicily have been published. Aim: to collect data from a 7-year survey. Methods: the charts of children discharged with the diagnosis of KD since January 2000 to December 2007, from the paediatric Units of 5 tertiary level Hospitals in Sicily were retrospectively reviewed. Data were collected through a questionnaire; gender, age at onset, ancestry, seasonality, ESR, CRP, PTL count, clinical manifestations, medication and cardiac abnormalities during the acute phase and up to 48 month follow-u were recorded. Results: 98 Caucasian children (55 M, 43 F, mean age at onset 36 mths), were diagnosed; 88/98 fulfilled the criteria while 10/98 had the incomplete form. The M: F ratio was 1.3: 1. 85% were children aged 36–40 months and 15% infants. Most cases occurred in August. The typical fever was present in 100%, conjunctivitis and exanthema in 98%, mucositis and extremity changes in 89%, and cervical lymphoadenopathy in 79% of patients. 87/98 pts had received timely IVIG; 4 patients required a second infusion. Cardiac abnormalities developed in 10 pts (6 ectasia and 4 aneurysms) all in the group with delayed therapy; 3/4 were giant aneurysms, all in infants. Three patients in addition to CAA displayed peripheral artery involvement. At 4-yr follow-up all CAA normalized except for 3 giant CAA that regressed to dilatations.


The incidence rate of KD in Sicily, sex distribution and cardiac abnormalities are comparable to European reports. The seasonal distribution is different with a peak in summer.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Vitale, A., La Torre, F., Barcellona, R. et al. Kawasaki disease in Sicily: a 7 year survey. Pediatr Rheumatol 6 (Suppl 1), P258 (2008).

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