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Subclinical aterosclerosis and Kawasaki Disease (KD): results from an e- tracking study of arterial stiffness in a Sicilian population

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Pediatric Rheumatology20086 (Suppl 1) :P257

  • Published:


  • Kawasaki Disease
  • Arterial Stiffness
  • Pulse Wave Velocity
  • Arterial Compliance
  • Stiffness Index


Patients with Kawasaki Disease (KD) may have an increased risk for early atherosclerosis. Arterial stiffness (AS) has recently recognized as a predictor of atherosclerosis. AIM of this study was to evaluate AS in a populations of KD patients (pts). The study was performed by means of E-tracking, a system measuring changes in arterial diameter synchronized with the ECG signal and permitting evaluation of pulse wave propagation velocity in a point of the vascular system.


Twenty children who had suffered from KD and 20-age- and sex-matched healthy controls were enrolled. In each subject, E-tracking was performed in both common carortid arteries. The following parameters were calculated: 1) Stiffness index, 2) Pulse wave velocity, 3) Elastic modulus, and arterial compliance. In addition, intima-media thickness (IMT) was measured.


Kawasaki patients' age at examination was 5 years; the mean time interval between the disease onset and the testing time was 3.5 years. Coronary involvement was recognized in 6 pts. All KD pts show a significant AS compromise as expressed by increase in stiffness index, pulse wave velocity and elastic modulus, as well as by arterial compliance decrease. IMT was normal.


Pts with KD show a clear arterial stiffening. This report is the first one describing changes in AS revealed by E-tracking in pts with KD; we suggest that E-tracking study could be more sensitive than IMT in revealing arterial damage in KD

Authors’ Affiliations

Department of Pediatrics, Pediatric Rheumatology, Messina, Italy
Department of Pediatrics, Pedaitric Cardiology, Messina, Italy
Department of Cardiology, Messina, Italy


  1. Dalla Pozza R: Subclinical atherosclerosis, but normal autonomic function after Kawasaki disease. J Pediatr. 2007, 151 (3): 239-43. 10.1016/j.jpeds.2007.03.057.View ArticlePubMedGoogle Scholar


© Vitale et al; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.