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Autoimmune response following influenza vaccination
Pediatric Rheumatology volume 6, Article number: P146 (2008)
The aim of this study was to assess autoimmune response following annual influenza vaccination in apparently healthy adults, staff at a children's hospital.
92 healthy adult subjects were tested for autoantibodies including antinuclear antibodies (ANA), anti-extractable nuclear antigen antibodies (anti-ENA), antiphospholipid antibodies (aPL), namely anticardiolipin antibodies (aCL), anti-beta2-glycoprotein I antibodies (aβ2-GPI) and lupus anticoagulant (LA). Blood samples were taken from each participant before annual influenza vaccination, one month and six months after vaccination.
Before influenza vaccination 26% of participants were positive for ANA, 1% for anti-ENA, 16% for aCL, 7% for aβ2-GPI and 2% for LA. One month after influenza vaccination 76% of participants showed no change in autoantibodies titres. Six months after influenza vaccination 74% of participants showed no change in autoantibodies titres. Overall, there was no statistically significant difference in the percentage of positive ANA, aCL, aβ2-GPI and LA before and 6 months after the vaccination. Five participants developed autoantibodies 6 months after the vaccination and one who was initially low positive for ANA became highly positive (1:320). Eleven participants had only transiently increased autoantibodies. Persistently positive or progressively increased levels of autoantibodies during 6 months' follow up were observed in 6 persons (7%).
Our study showed a high percentage of positive autoantibody testing among healthy adult staff at a children's hospital. There was no statistically significant difference in the percentage of positive autoantibodies before and after influenza vaccination. However, our study clearly demonstrated induction of autoantibodies production in selected subjects.
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Toplak, N., Kveder, T., Trampus-Bakija, A. et al. Autoimmune response following influenza vaccination. Pediatr Rheumatol 6, P146 (2008) doi:10.1186/1546-0096-6-S1-P146
- Influenza Vaccination
- Autoimmune Response
- Lupus Anticoagulant
- Anticardiolipin Antibody