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Mycobacterial arthritis as a complication of a Bacille Calmette-Guérin (BCG) vaccination in an immunocompetent child
Pediatric Rheumatology volume 6, Article number: P136 (2008)
BCG vaccine (attenuated strain of virulent Mycobacterium bovis) is worldwide administered in the first weeks of life. Systemic BCG infection or osteomyelitis are rare infrequent complications especially in immunocompromised individuals. We report a case of an immunocompetent infant with BCG arthritis.
A 17 month old boy presented with monoarthritis involving his knee, which started 7 month earlier, responding to NSAID therapy, respectively. On physical examination the only finding was the painful effusion and functional limitation of the right knee, with hyperaemic skin reaction above it. His BCG scar was normal. Laboratory evaluation showed mildly elevated CRP (21 mg/l) and C3. RF, ANA, ENA and serological tests for infections were unrevealing. X-ray showed bony owergrowth of the distal femoral epyphisis without osteomyelitis. Ultrasound and MRI of the knee showed intra- and extraarticular effusion. Aspirates were turbid with 95% of polymorphs and were sterile with culture, no presence of acid-fast bacilli were detected. Further culture identified BCG vaccine strain of M. bovis. Twelve weeks of isoniacid therapy was ineffective, surgical bursectomy gave a complete healing. Histological examination revealed granulomatous inflammation with ceasating necrosis. Hypererg PPD test, normal T-cell functions, NBT-test and analysis of the IFNγ/IL-12 pathway ruled out primary immunodeficiency, HIV-test was negative as well.
BCG arthritis (chronic, painful, affecting the bursa) is a rare complication of the vaccine after a long latent period. Detecting BCG mycobacterium with PCR-reaction from the aspirat could shorten the diagnostic time. Primary immunodeficiencies associated with an increased susceptibility to mycobacterial infections should be ruled out.
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Dérfalvi, B., Verebély, T., Kovács, L. et al. Mycobacterial arthritis as a complication of a Bacille Calmette-Guérin (BCG) vaccination in an immunocompetent child. Pediatr Rheumatol 6, P136 (2008). https://doi.org/10.1186/1546-0096-6-S1-P136
- Primary Immunodeficiency
- Mycobacterial Infection
- Granulomatous Inflammation
- Nsaid Therapy