Skip to main content


Treatment of the low bone mineral density with intravenous pamidronate in pediatric patients: review of a protocol of a single-day infusion twice a year


On the basis of effectiveness of bisphosphonates in adults, a simple protocol for the treatment of low bone mineral density in children was developed in 1995 in our centre. Objectives: To review the effectiveness of a single-day infusion of pamidronate twice a year in children. Secondary, to describe its efficacy in relation to the etiology of osteoporosis.

Materials and methods

Retrospective review of patients treated with pamidronate from January 1995 to June 2006 in Sant Joan de Déu hospital (Spain). Patients:younger than 18 years that underwent treatment with the protocol for at least one year and with z-score < -2.5, fractures and z-score < -1 or documented bone pain with z-score < -1. They were classified into 4 groups: osteogenesis imperfecta, chronic treatment with steroids, disuse and other conditions. Interventions: single intravenous administration of pamidronate (30 mg in prepubescent patients and 60 mg in all other patients) every six months. Clinical, radiological data and bone mineral density were obtained basal and after each cycle. For each patient the ratio fractures/year during the treatment and the total increase in z-score (total ΔZ) after the treatment were calculated.


56 patients were included. Overall, fractures/year decreased from 1.75 basal to 0.46 during the treatment. Osteogenesis imperfecta group had better total ΔZ (1.25). Disuse group had clinical improvement although poor total ΔZ increase (0.12).


There is a clinical improvement in all patients. The OI group has the best gain in bone mineral mass. The protocol is safe, simple and well tolerated by patients and families.

Author information

Correspondence to S Ricart.

Rights and permissions

Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and Permissions

About this article


  • Bone Mineral Density
  • Osteoporosis
  • Bone Mineral
  • Intravenous Administration
  • Clinical Improvement