- Poster presentation
- Open Access
Neuropsychiatric manifestations in juvenile systemic lupus erythematosus: what’s the weight of headache?
© Torreggiani et al; licensee BioMed Central Ltd. 2014
- Published: 17 September 2014
- Damage Index
- Lupus Anticoagulant
- SLEDAI Score
- Neuropsychiatric Manifestation
- Juvenile Systemic Lupus Erythematosus
Juvenile Systemic Lupus Erythematosus (JSLE) is an autoimmune disease characterized by multiple organ involvement. The nervous system is often affected, with a higher frequency in children than in adults.
To examine prevalence and features of neuropsychiatric manifestations in JSLE, focusing on headache.
The records of all patients satisfying the ACR criteria for JSLE admitted to our Hospital from 1980 to May 2014 were retrospectively reviewed. Disease activity at onset was measured by SLE disease activity index (SLEDAI); organ damage was assessed at last follow-up using the SLICC/ACR Damage Index (SDI). Using the 1999 ACR nomenclature for neuropsychiatric (NP) lupus syndromes, patients were divided in patients with (NPSLE) and without (nNPSLE) NP involvement. Headache was defined as in the ACR nomenclature (ACR headache), as in SLEDAI (SLEDAI headache) and as “severe persistent headache; may be migrainous” (LHA).
Most common central nervous system neuropsychiatric syndromes
Overall (n. of patients)
At onset (n. of patients)
Later during the disease course (n. of patients)
- ACR headache
- SLEDAI headache
Movement disorder (chorea)
Consistently with the literature, more than a half of our JSLE patients presented NP involvement. Headache is a frequent manifestation: it was reported in 38,8% JSLE and 72,5% NPSLE patients. Headache in JSLE deserves an accurate investigation. In the subset of NPSLE patients, positivity of LAC and APL did not significantly correlate with headache, which may also be due to small number of cases. Further prospective studies are needed to better understand and define headache in JSLE.
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