- Poster presentation
- Open Access
Administration of routine preventative vaccinations in children with polyarticular juvenile idiopathic arthritis receiving adalimumab
© Minden et al; licensee BioMed Central Ltd. 2014
- Published: 17 September 2014
- Human Papilloma Virus
- Influenza Vaccine
Adalimumab (ADA) has been shown to be safe and effective in polyarticular juvenile idiopathic arthritis (pJIA), and is approved for use in moderate to severe pJIA patients (pts) ≥4 years (yrs) in the US, Australia, and Japan, and in the EU for pts ≥2 yrs.
This post hoc report describes the observed use of vaccines in pJIA pts receiving ADA in 3 clinical trials and one registry.
Pts with active pJIA were enrolled in one of the following trials: M10-444 (ages 2 to <4 or ≥4 weighing <15 kg in US, EU), M10-240 (ages 4-17 in Japan), DE038 (ages 4-17 in US, EU) or the STRIVE (P10-262) registry (ages 4-17 in US, EU, and Australia). Pts received ADA±methotrexate. Vaccinations were administered based on the judgment of the study investigator or the treating physician. Descriptive statistics were used to summarize all vaccinations. Adverse events (AEs) related to active influenza virus infection events occurring within 270 days after influenza vaccination were collected by a predefined MedDRA query 15.1 [Lack of efficacy/effect Influenza (Vaccination Product Specific)].
Total patients vaccinated, n/N
Mean age, yrs (SD)
Total vaccinations, n
Patients with >1 type of vaccination, n
Different types of vaccinations, n
Mean time to 1st vaccination*, days
Mean age at 1st vaccination*, yrs
These data support the idea that pJIA pts treated with ADA can be immunized with routine, inactive, preventative vaccines. Not all of the eligible pts were vaccinated on time according to the Centers of Disease Control (CDC) recommendations, and many pts were not vaccinated at all, suggesting that physicians may be reluctant to use vaccines in children receiving antirheumatic therapies. Further investigation of vaccination practices for pts with JIA is warranted.
NCT00774537, NCT00690573, NCT00048542 and NCT00783510
K. Minden Grant / Research Support from: AbbVie, Pfizer, Consultant for: Pfizer, AbbVie, Roche/Chugai, Novartis, Medac, Pharm-Allergan, Speaker Bureau of: Pfizer, AbbVie, Roche/Chugai, Novartis, Medac, Pharm-Allergan, M. Karunaratne Shareholder of: AbbVie, Employee of: AbbVie, H. Kupper Shareholder of: AbbVie, Employee of: AbbVie, J. Kalabic Shareholder of: AbbVie, Employee of: AbbVie
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