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Share – Workpackage 5: evidence based recommendations for diagnosis and treatment of juvenile idiopathic arthritis

Introduction

Juvenile Idiopathic Arthritis (JIA) is one of the most common chronic pediatric rheumatic diseases (PRD). As is the case for most PRD's, evidence-based guidelines are sparse and management is based to great extent on physician’s experience. Moreover, there are differences between nations regarding availability and financing of biological therapies. Consequently, treatment regimens differ throughout Europe. In 2012, a European initiative called SHARE (Single Hub and Access point for pediatric Rheumatology in Europe) was launched to optimize and disseminate diagnostic and management regimens in Europe for children and young adults with rheumatic diseases.

Objectives

To provide evidence based recommendations for diagnosis and treatment of JIA.

Methods

Evidence based recommendations were developed using the European League Against Rheumatism (EULAR) standard operating procedure [1]. An expert committee was instituted, consisting of pediatric rheumatologists from across Europe with expertise in JIA. The expert committee defined search terms for the systematic literature review. Two independent experts scored articles for validity and level of evidence. Recommendations derived from the literature were evaluated by an online survey. Those with less than 80% agreement during the online survey were reformulated. Subsequently, all recommendations were discussed by the experts at a consensus meeting using the nominal group technique [2]. Recommendations were accepted if more than 80% agreement was reached.

Results

The literature search yielded 4723 articles, of which 174 were considered relevant. The included articles were scored for validity and level of evidence. Recommendations were formulated based on the valid papers and were discussed and adjusted where needed during the consensus meeting. In total, 10 recommendations for diagnosis and 31 for treatment were accepted with more than 80% agreement. Topics covered for diagnosis and for treatment are shown in Table 1.

Table 1 Table 1

Conclusion

The SHARE initiative provides recommendations for diagnosis and treatment of JIA and thereby facilitates improvement and uniformity of care throughout Europe. In the subsequent phase of the project, best practices identified from literature will be completed with the ‘experts opinion’ in order to formulate diagnostic and management guidelines as best practices for care of JIA patients throughout Europe.

Disclosure of interest

S. Vastert Consultant for: Novartis, V. Boom: None Declared, A. Ravelli: None Declared, A. Martini: None Declared, H. Foster: None Declared, N. Wulffraat Grant / Research Support from: Abbvie, GSK, Roche, Consultant for: Novartis, Genzyme, Roche, Pfizer.

References

  1. 1.

    Dougados : Annals of the Rheumatic Diseases. 2004

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  2. 2.

    de Ven : American Journal of Public Health. 1972

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Correspondence to Sebastiaan Vastert.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Vastert, S., Boom, V., Ravelli, A. et al. Share – Workpackage 5: evidence based recommendations for diagnosis and treatment of juvenile idiopathic arthritis. Pediatr Rheumatol 12, P171 (2014). https://doi.org/10.1186/1546-0096-12-S1-P171

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Keywords

  • Juvenile Idiopathic Arthritis
  • Online Survey
  • Standard Operating Procedure
  • Systematic Literature Review
  • Expert Committee