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Epigenetics in rheumatic diseases
Pediatric Rheumatology volume 12, Article number: I12 (2014)
With enormous speed novel data are emerging about regulating the expression of the genetically encoded information . This highly complex regulatory network called epigenetics includes acetylation, methylation, phosphorylation, sumoylation and non-coding RNAs (ncRNA), such as miRNA and lncRNAs. Our laboratory is addressing over the past decade inflammatory rheumatic diseases , like rheumatoid arthritis (RA), AS, SSc and pulmonary hypertension and thereby searching for the regulation of pro-inflammatory cytokines [3, 4], novel diagnostic signatures and new therapeutic targets. In this regard, DNA demethylation of RA synovial cells can be modulated by targeting specific enzymes . Also, miRNA signatures for new response markers are in development .
Disclosure of interest
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Gay, S. Epigenetics in rheumatic diseases. Pediatr Rheumatol 12, I12 (2014). https://doi.org/10.1186/1546-0096-12-S1-I12
- Public Health
- Rheumatoid Arthritis
- Therapeutic Target