Skip to content

Advertisement

  • Invited speaker presentation
  • Open Access

Epigenetics in rheumatic diseases

  • 1
Pediatric Rheumatology201412 (Suppl 1) :I12

https://doi.org/10.1186/1546-0096-12-S1-I12

  • Published:

Keywords

  • Public Health
  • Hypertension
  • Rheumatoid Arthritis
  • Arthritis
  • Therapeutic Target

With enormous speed novel data are emerging about regulating the expression of the genetically encoded information [1]. This highly complex regulatory network called epigenetics includes acetylation, methylation, phosphorylation, sumoylation and non-coding RNAs (ncRNA), such as miRNA and lncRNAs. Our laboratory is addressing over the past decade inflammatory rheumatic diseases [2], like rheumatoid arthritis (RA), AS, SSc and pulmonary hypertension and thereby searching for the regulation of pro-inflammatory cytokines [3, 4], novel diagnostic signatures and new therapeutic targets. In this regard, DNA demethylation of RA synovial cells can be modulated by targeting specific enzymes [5]. Also, miRNA signatures for new response markers are in development [6].

Disclosure of interest

None declared.

Authors’ Affiliations

(1)
Rheumatology, University Hospital, Zürich, Switzerland

References

  1. Dunham I: An integrated encyclopedia of DNA elements in the human genome. Nature. 2012, 489: 57-74.View ArticleGoogle Scholar
  2. Gay S, Wilson AG: The emerging role of epigenetics in rheumatic diseases. Rheumatology. 2013, (Epub ahead of print)Google Scholar
  3. Brock M: MicroRNA-18a enhances the IL-6 mediated production of the acute-phase proteins fibrinogen and haptoglobin in human hepatocytes. J Biol Chem. 2011, 286: 40142-50.PubMed CentralView ArticlePubMedGoogle Scholar
  4. Trenkmann M, Brock M, Gay RE, Michel BA, Gay S, Huber LC: The TNFα-induced miR-18a activates rheumatoid arthritis synovial fibroblasts through a feedback loop in NF-κB signaling. Arthritis Rheum. 2013, 65: 916-27.View ArticlePubMedGoogle Scholar
  5. Neidhart M, Karouzakis E, Jüngel A, Gay RE, Gay S: Inhibition of spermidine/spermine N1-acetyltransferase (SSAT1) activity - a new therapeutical concept in rheumatoid arthritis. Arthritis Rheumatol. 2014, [Epub ahead of print]Google Scholar
  6. Filková M: Association of circulating miR-223 and miR-16 with disease activity in patients with early rheumatoid arthritis. Ann Rheum Dis. 2013, (Epub ahead of print)Google Scholar

Copyright

© Gay; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Advertisement