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Epigenetics in rheumatic diseases

With enormous speed novel data are emerging about regulating the expression of the genetically encoded information [1]. This highly complex regulatory network called epigenetics includes acetylation, methylation, phosphorylation, sumoylation and non-coding RNAs (ncRNA), such as miRNA and lncRNAs. Our laboratory is addressing over the past decade inflammatory rheumatic diseases [2], like rheumatoid arthritis (RA), AS, SSc and pulmonary hypertension and thereby searching for the regulation of pro-inflammatory cytokines [3, 4], novel diagnostic signatures and new therapeutic targets. In this regard, DNA demethylation of RA synovial cells can be modulated by targeting specific enzymes [5]. Also, miRNA signatures for new response markers are in development [6].

Disclosure of interest

None declared.

References

  1. 1.

    Dunham I: An integrated encyclopedia of DNA elements in the human genome. Nature. 2012, 489: 57-74.

    CAS  Article  Google Scholar 

  2. 2.

    Gay S, Wilson AG: The emerging role of epigenetics in rheumatic diseases. Rheumatology. 2013, (Epub ahead of print)

    Google Scholar 

  3. 3.

    Brock M: MicroRNA-18a enhances the IL-6 mediated production of the acute-phase proteins fibrinogen and haptoglobin in human hepatocytes. J Biol Chem. 2011, 286: 40142-50.

    PubMed Central  CAS  Article  PubMed  Google Scholar 

  4. 4.

    Trenkmann M, Brock M, Gay RE, Michel BA, Gay S, Huber LC: The TNFα-induced miR-18a activates rheumatoid arthritis synovial fibroblasts through a feedback loop in NF-κB signaling. Arthritis Rheum. 2013, 65: 916-27.

    CAS  Article  PubMed  Google Scholar 

  5. 5.

    Neidhart M, Karouzakis E, Jüngel A, Gay RE, Gay S: Inhibition of spermidine/spermine N1-acetyltransferase (SSAT1) activity - a new therapeutical concept in rheumatoid arthritis. Arthritis Rheumatol. 2014, [Epub ahead of print]

    Google Scholar 

  6. 6.

    Filková M: Association of circulating miR-223 and miR-16 with disease activity in patients with early rheumatoid arthritis. Ann Rheum Dis. 2013, (Epub ahead of print)

    Google Scholar 

Download references

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Correspondence to Steffen Gay.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Gay, S. Epigenetics in rheumatic diseases. Pediatr Rheumatol 12, I12 (2014). https://doi.org/10.1186/1546-0096-12-S1-I12

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Keywords

  • Public Health
  • Hypertension
  • Rheumatoid Arthritis
  • Arthritis
  • Therapeutic Target