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  • Invited speaker presentation
  • Open Access

Epigenetics in rheumatic diseases

  • 1
Pediatric Rheumatology201412 (Suppl 1) :I12

https://doi.org/10.1186/1546-0096-12-S1-I12

  • Published:

Keywords

  • Public Health
  • Hypertension
  • Rheumatoid Arthritis
  • Arthritis
  • Therapeutic Target

With enormous speed novel data are emerging about regulating the expression of the genetically encoded information [1]. This highly complex regulatory network called epigenetics includes acetylation, methylation, phosphorylation, sumoylation and non-coding RNAs (ncRNA), such as miRNA and lncRNAs. Our laboratory is addressing over the past decade inflammatory rheumatic diseases [2], like rheumatoid arthritis (RA), AS, SSc and pulmonary hypertension and thereby searching for the regulation of pro-inflammatory cytokines [3, 4], novel diagnostic signatures and new therapeutic targets. In this regard, DNA demethylation of RA synovial cells can be modulated by targeting specific enzymes [5]. Also, miRNA signatures for new response markers are in development [6].

Disclosure of interest

None declared.

Authors’ Affiliations

(1)
Rheumatology, University Hospital, Zürich, Switzerland

References

  1. Dunham I: An integrated encyclopedia of DNA elements in the human genome. Nature. 2012, 489: 57-74.View ArticleGoogle Scholar
  2. Gay S, Wilson AG: The emerging role of epigenetics in rheumatic diseases. Rheumatology. 2013, (Epub ahead of print)Google Scholar
  3. Brock M: MicroRNA-18a enhances the IL-6 mediated production of the acute-phase proteins fibrinogen and haptoglobin in human hepatocytes. J Biol Chem. 2011, 286: 40142-50.PubMed CentralView ArticlePubMedGoogle Scholar
  4. Trenkmann M, Brock M, Gay RE, Michel BA, Gay S, Huber LC: The TNFα-induced miR-18a activates rheumatoid arthritis synovial fibroblasts through a feedback loop in NF-κB signaling. Arthritis Rheum. 2013, 65: 916-27.View ArticlePubMedGoogle Scholar
  5. Neidhart M, Karouzakis E, Jüngel A, Gay RE, Gay S: Inhibition of spermidine/spermine N1-acetyltransferase (SSAT1) activity - a new therapeutical concept in rheumatoid arthritis. Arthritis Rheumatol. 2014, [Epub ahead of print]Google Scholar
  6. Filková M: Association of circulating miR-223 and miR-16 with disease activity in patients with early rheumatoid arthritis. Ann Rheum Dis. 2013, (Epub ahead of print)Google Scholar

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