PReS-FINAL-2020: Cell type specific transcriptome analysis in patients with enthesitis related arthritis category of juvenile idiopathic arthritis (JIA-ERA)

Table 1

Groups compared	Genes up regulated	Genes down regulated	Number of dysregulated pathways [total (significant)]	Pathways of immunological relevance
EB vs EF	776	189	19 (12)	Cell adhesion, IgA production, antigen processing, lysosomal processing
CBMO vs EBMO	821	1251	21 (12)	Cytokine signaling, TLR signaling, antigen presentation, chemokines signaling
EBMO vs EFMO	595	512	17 (9)	Complement cascade, cytokine signaling, antigen presentation

EB: ERA blood mononuclear cells, CB: control blood mononuclear cells, EF: ERA Synovial fluid mononuclear cells, Mo: CD14+ monocytes, The major differences were found in monocyte subset. TLR pathway was one of the major pathway identified besides antigen presentation, cytokine and chemokine signalling.

ISSN: 1546-0096